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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
GRANDEM 1MG INJECTION 1ML is used to treat nausea and vomiting caused by medical treatments after surgery, chemotherapy, or radiation treatment for cancer. It contains Granisetron, which works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery. Common side effects of GRANDEM 1MG INJECTION 1ML include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site.
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Whats That

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About GRANDEM 1MG INJECTION 1ML

GRANDEM 1MG INJECTION 1ML belongs to the class of 'anti-emetic' drugs, primarily used to treat nausea and vomiting caused by medical treatments after surgery or chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

GRANDEM 1MG INJECTION 1ML contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

GRANDEM 1MG INJECTION 1ML will be administered by a healthcare professional; do not self-administer. Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of GRANDEM 1MG INJECTION 1ML include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using GRANDEM 1MG INJECTION 1ML. Let your doctor know if you have any liver, kidney or heart diseases, stomach/intestinal problems, allergic reactions, and low levels of potassium and magnesium in the blood before starting GRANDEM 1MG INJECTION 1ML. This medicine may make you dizzy or drowsy; hence avoid driving or operating machinery if you are not mentally alert. Consult your doctor before using GRANDEM 1MG INJECTION 1ML if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol while being treated with GRANDEM 1MG INJECTION 1ML as it could lead to unwanted side effects. 

Uses of GRANDEM 1MG INJECTION 1ML

Treatment of Nausea and vomiting

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

GRANDEM 1MG INJECTION 1ML contains an anti-emetic medicine, 'Granisetron', that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. GRANDEM 1MG INJECTION 1ML works by blocking the brain's serotonin activity and preventing postoperative nausea and vomiting. 

How GRANDEM 1MG INJECTION 1ML Works

GRANDEM 1MG INJECTION 1ML contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of GRANDEM 1MG INJECTION 1ML

  • Diarrhoea
  • Constipation
  • Stomach pain
  • Weakness
  • Headache
  • Fever
  • Dizziness
  • Drowsiness
  • Trouble sleeping
  • Pain, redness, and swelling at the injection site

What if I have taken an overdose of GRANDEM 1MG INJECTION 1ML

Since GRANDEM 1MG INJECTION 1ML is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of GRANDEM 1MG INJECTION 1ML may cause headache.

Drug Warnings

Seeking medical advice if you use prescription or non-prescription medicines while being treated with GRANDEM 1MG INJECTION 1ML is suggested. Inform your doctor about a history of stomach/intestinal problems, heart diseases, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting GRANDEM 1MG INJECTION 1ML. Please consult your doctor if you are pregnant or breastfeeding if the doctor advised you GRANDEM 1MG INJECTION 1ML. This medicine may make you feel dizzy, so drive or operate machinery only if you are alert. Avoid consuming alcohol during the course, as it could lead to increased dizziness. GRANDEM 1MG INJECTION 1ML is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronSaquinavir
Critical
GranisetronSparfloxacin
Critical

Drug-Drug Interactions

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GranisetronSaquinavir
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
When Grandem 1mg Injection 1ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSparfloxacin
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronThioridazine
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronCisapride
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronZiprasidone
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDronedarone
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronMesoridazine
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem 1mg Injection 1ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronPimozide
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDoxepin
Severe
How does the drug interact with Grandem 1mg Injection 1ml:
The use of Grandem 1mg Injection 1ml and doxepin can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in body) and increase the risk of irregular heart rhythms.

How to manage the interaction:
Co-administration of Grandem 1mg Injection 1ml and Doxepin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, diarrhea, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
GranisetronVilazodone
Severe
How does the drug interact with Grandem 1mg Injection 1ml:
When Vilazodone is taken with Grandem 1mg Injection 1ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
Co-administration of Grandem 1mg Injection 1ml with Vilazodone can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. 
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables, and fruits.
  • You can include antioxidants in your daily diet, like ashwagandha, omega-3 fatty acids, green tea, and lemon.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

GRANDEM 1MG INJECTION 1ML Substitute

Substitutes safety advice
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  • Grandem Syrup 10 ml

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    5.31per tablet
  • Graniforce Syrup 10 ml

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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking GRANDEM 1MG INJECTION 1ML. Alcohol intake, along with GRANDEM 1MG INJECTION 1ML, may lead to unwanted side effects and cause increased dizziness.

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Pregnancy

Caution

It is not known if GRANDEM 1MG INJECTION 1ML affects pregnancy. Please inform your doctor if you are pregnant or planning pregnancy before receiving GRANDEM 1MG INJECTION 1ML.

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please inform your doctor before taking GRANDEM 1MG INJECTION 1ML if you are a nursing mother.

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Driving

Caution

GRANDEM 1MG INJECTION 1ML may make you feel dizzy, affecting your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

GRANDEM 1MG INJECTION 1ML should be used with caution if you have liver disease. Please inform your doctor if you have a history of liver impairment before starting GRANDEM 1MG INJECTION 1ML.

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Kidney

Caution

GRANDEM 1MG INJECTION 1ML should be used with caution if you have kidney problems. Please inform your doctor if you have a history of kidney impairment/kidney disease.

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Children

Caution

Safety and efficacy of GRANDEM 1MG INJECTION 1ML have not been established in children below 2 years of age.

FAQs

GRANDEM 1MG INJECTION 1ML is used to treat Nausea and vomiting.

GRANDEM 1MG INJECTION 1ML contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, GRANDEM 1MG INJECTION 1ML relieves post-operative nausea and vomiting symptoms.

GRANDEM 1MG INJECTION 1ML may cause constipation as one of its side effects. You can avoid it by including high-fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

GRANDEM 1MG INJECTION 1ML should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick, difficulty passing stools, heart rhythm disorder, a recent stomach or intestinal surgery, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Common side effects of GRANDEM 1MG INJECTION 1ML include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

It is not known if GRANDEM 1MG INJECTION 1ML affects pregnancy. Please inform your doctor if you are pregnant or planning pregnancy before receiving GRANDEM 1MG INJECTION 1ML. The doctor will prescribe GRANDEM 1MG INJECTION 1ML only if clearly needed.

Few studies suggest that GRANDEM 1MG INJECTION 1ML is more effective than ondansetron. However, the doctor will decide which medicine is suitable and better for you based on your condition.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - GRA0008

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