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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 5:55 AM IST

Grandem MD Tablet is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. In some cases, this medicine may cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition

GRANISETRON-1MG

Manufacturer/Marketer

Aristo Pharmaceuticals Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Grandem MD Tablet

Grandem MD Tablet belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Grandem MD Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Grandem MD Tablet include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping , and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Grandem MD Tablet . Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions, and low levels of potassium and magnesium in the blood before starting Grandem MD Tablet . Grandem MD Tablet may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Grandem MD Tablet if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Grandem MD Tablet as it could lead to increased drowsiness.

Uses of Grandem MD Tablet

Grandem MD Tablet is used to treat nausea and vomiting.

Medicinal Benefits

Grandem MD Tablet contains an anti-emetic drug, 'Granisetron' that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induce nausea and vomiting. Grandem MD Tablet works by blocking the activity of serotonin in the brain and preventing post-operative nausea and vomiting.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water, do not chew, crush or break it.Syrup/Liquid: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Grandem MD Tablet

  • Diarrhoea
  • Constipation
  • Stomach pain
  • Weakness
  • Headache
  • Fever
  • Dizziness
  • Drowsiness
  • Trouble sleeping
  • Anxiety

Drug Warnings

Grandem MD Tablet may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Grandem MD Tablet . Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Grandem MD Tablet . Grandem MD Tablet may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Grandem MD Tablet is not recommended in children below two years of age.

Drug Interactions

Drug-Drug Interaction: Grandem MD Tablet may interact with antidepressants (lithium, duloxetine), heart-related drugs (amiodarone, quinidine), antipsychotic drugs (pimozide), HIV/AIDS drugs (ritonavir), antibiotics (erythromycin) and St. John's wort, a plant-based medicine used for depression and mood disorders.

Drug-Food Interaction: Avoid alcohol consumption while being treated with Grandem MD Tablet to prevent adverse effects.

Drug-Disease Interaction: Before using Grandem MD Tablet , let your doctor know if you have any stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), liver or kidney diseases.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DULOXETINE
  • AMIODARONE
  • QUINIDINE
  • RITONAVIR
  • ERYTHROMYCIN

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Special Advise

Let your doctor know that you are taking Grandem MD Tablet if you are undergoing any medical tests.

Disease/Condition Glossary

Nausea is defined as stomach discomfort and the sensation of an urge to vomit. It is a precursor to vomiting. It is not a painful symptom but can cause discomfort in the chest, upper abdomen or back of the throat. Nausea can be triggered by various factors like motion from a car and plane, taking pills on an empty stomach, eating too much or too little and drinking excessive amounts of alcohol.

Vomiting or throwing up is the forcible voluntary or involuntary emptying of the stomach contents through the mouth. Vomiting can also occur without having any underlying diseases in conditions like pregnancy, hangover, overeating and motion sickness. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer or bulimia (eating disorder).

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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Grandem MD Tablet . Alcohol intake, along with Grandem MD Tablet , may cause increased dizziness.

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Pregnancy

Caution

It is not known if Grandem MD Tablet affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Grandem MD Tablet .

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Grandem MD Tablet if you are a nursing mother.

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Driving

Caution

Grandem MD Tablet may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Grandem MD Tablet should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Grandem MD Tablet .

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Kidney

Caution

Grandem MD Tablet should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Caution

Safety and efficacy of Grandem MD Tablet are not established in children below 2 years of age.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - GRA0162

Author Details

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FAQs

Grandem MD Tablet is used to treat nausea and vomiting caused by medical treatments.
Grandem MD Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem MD Tablet relieves from post-operative nausea and vomiting symptoms.
Grandem MD Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.
Grandem MD Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.
You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.
Take Grandem MD Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

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