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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dauneon 20mg Injection 1 ml is an antineoplastic medicine used in the treatment of cancer. It contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying DNA and RNA synthesis. Thus, Dauneon 20mg Injection 1 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way, and causes cancer cell death.

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Synonym :

DAUNORUBICIN HYDROCHLORIDE

Composition :

DAUNORUBICIN-20MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Dauneon 20mg Injection 1 ml

Dauneon 20mg Injection 1 ml is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Dauneon 20mg Injection 1 ml helps to induce remission of nonlymphocytic leukemia (myelogenous, monocytic, erythroid) and acute lymphocytic leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

Dauneon 20mg Injection 1 ml contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Dauneon 20mg Injection 1 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Dauneon 20mg Injection 1 ml may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, fever, chills, and pain at the site of injection. Most of these side effects of Dauneon 20mg Injection 1 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Dauneon 20mg Injection 1 ml is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

Dauneon 20mg Injection 1 ml should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Dauneon 20mg Injection 1 ml. Dauneon 20mg Injection 1 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Dauneon 20mg Injection 1 ml as it may increase the risk of liver damage. This medicine may be recommended for use in children only if the benefits outweigh the risks.

Uses of Dauneon 20mg Injection 1 ml

Treatment of lymphocytic leukemia, and Acute non-lymphocytic leukemia

Directions for Use

Your doctor will administer Dauneon 20mg Injection 1 ml. Hence, do not self-administer.

Medicinal Benefits

Dauneon 20mg Injection 1 ml contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Dauneon 20mg Injection 1 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

How Dauneon 20mg Injection 1 ml Works

Dauneon 20mg Injection 1 ml contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Dauneon 20mg Injection 1 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dauneon 20mg Injection 1 ml

  • Vomiting
  • Nausea
  • Mouth ulcers
  • Loss of appetite
  • Diarrhoea
  • Dizziness
  • Weakness
  • Injection site reactions
  • Pain at the site of injection

What if I have taken an overdose of Dauneon 20mg Injection 1 ml

Dauneon 20mg Injection 1 ml is administered in a hospital setting under the supervision of your doctor or medical personnel. Thus, an overdose is quite improbable. While in the hospital, you will be constantly monitored to ensure that any unpleasant side effects are handled.

Drug Warnings

Dauneon 20mg Injection 1 ml should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Dauneon 20mg Injection 1 ml. Dauneon 20mg Injection 1 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Dauneon 20mg Injection 1 ml as it may increase the risk of liver damage. Avoid excessive exposure to sunlight as Dauneon 20mg Injection 1 ml may cause sensitivity to sunlight. You are advised to use sunscreen and wear protective clothing while going out. If you are about to receive any vaccinations, inform your doctor that you are taking Dauneon 20mg Injection 1 ml as it may cause infections.

Drug-Drug Interactions

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DaunorubicinZiprasidone
Critical
DaunorubicinMifepristone
Severe

Drug-Drug Interactions

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DaunorubicinZiprasidone
Critical
How does the drug interact with Dauneon 20mg Injection 1 ml:
Taking Dauneon 20mg Injection 1 ml with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Dauneon 20mg Injection 1 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DaunorubicinMifepristone
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Co-administration of Dauneon 20mg Injection 1 ml with mifepristone may increase the risk of an abnormal heart rate, prolonged treatment with Mifepristone may also cause low potassium levels in the body.

How to manage the interaction:
Taking Dauneon 20mg Injection 1 ml with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
DaunorubicinHaloperidol
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Co-administration of Dauneon 20mg Injection 1 ml with Haloperidol can increase the risk of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Dauneon 20mg Injection 1 ml with Haloperidol together can possibly result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting your doctor.
DaunorubicinTofacitinib
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
When Tofacitinib is taken with Dauneon 20mg Injection 1 ml, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Dauneon 20mg Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
DaunorubicinClozapine
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
When Clozapine is taken with Dauneon 20mg Injection 1 ml, may increase the risk of infection and irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Dauneon 20mg Injection 1 ml and Clozapine, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include problems with your immune system, heart rhythm, or signs of infection like fever, chills, or a sore throat. Other symptoms to watch out for are muscle aches, difficulty breathing, unexplained weight loss, pain, sudden dizziness, feeling lightheaded, fainting, or heart palpitations. Do not stop using any medications without first talking to your doctor.
DaunorubicinEtanercept
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
When Etanercept is used with Dauneon 20mg Injection 1 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Dauneon 20mg Injection 1 ml and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DaunorubicinMoxifloxacin
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Using Moxifloxacin together with Dauneon 20mg Injection 1 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Dauneon 20mg Injection 1 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or heart palpitations, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DaunorubicinSotalol
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Using Dauneon 20mg Injection 1 ml together with sotalol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Dauneon 20mg Injection 1 ml, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
DaunorubicinNilotinib
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Coadministration of Dauneon 20mg Injection 1 ml and Nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dauneon 20mg Injection 1 ml and Nilotinib together can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DaunorubicinChloroquine
Severe
How does the drug interact with Dauneon 20mg Injection 1 ml:
Using chloroquine together with danorubicin can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking chloroquine and Dauneon 20mg Injection 1 ml together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking Dauneon 20mg Injection 1 ml as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Dauneon 20mg Injection 1 ml Substitute

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  • Daunocin 20mg Injection

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Alcohol

Unsafe

Avoid consumption of alcohol with Dauneon 20mg Injection 1 ml as it may increase the risk of liver damage.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving Dauneon 20mg Injection 1 ml.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Dauneon 20mg Injection 1 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

Dauneon 20mg Injection 1 ml causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Dauneon 20mg Injection 1 ml.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Dauneon 20mg Injection 1 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Dauneon 20mg Injection 1 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Dauneon 20mg Injection 1 ml can be recommended for acute lymphocytic leukemia in children. Please consult your doctor. Your child's doctor may prescribe a suitable dose based on the condition and age of your child. If this medicine is given, the child should be observed carefully for any unwanted effects.

FAQs

Dauneon 20mg Injection 1 ml is used to treat lymphocytic leukemia, and Acute non-lymphocytic leukemia.
Dauneon 20mg Injection 1 ml contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.
Dauneon 20mg Injection 1 ml may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Dauneon 20mg Injection 1 ml if you are planning to become a parent.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Dauneon 20mg Injection 1 ml as it may cause infections.
Yes, Dauneon 20mg Injection 1 ml is a vesicant (irritant) which means, it can cause severe tissue damage if it leaks into the surrounding tissues during injection (extravasation).
Dauneon 20mg Injection 1 ml should be administered by the doctor or nurse through an intravenous route (into a vein). Do not self-administer.
The frequency and duration of treatment may vary depending on your medical condition being treated. Always follow the doctor's instructions regarding the dosing schedule to get full benefits.
The side effects of Dauneon 20mg Injection 1 ml include mouth ulcers, diarrhoea, vomiting, nausea, loss of appetite, dizziness, weakness, fever, chills, and pain at the site of injection. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - DAU0010

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