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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:19 PM IST

Daunomac-20 Injection 1's is an antineoplastic medicine used in the treatment of cancer. It contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way, and causes cancer cell death.

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Synonym

DAUNORUBICIN HYDROCHLORIDE

Manufacturer/Marketer

Admac Lifesciences(Oncology)

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Daunomac-20 Injection 1's

Daunomac-20 Injection 1's is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Daunomac-20 Injection 1's helps to induce remission of nonlymphocytic leukemia (myelogenous, monocytic, erythroid) and acute lymphocytic leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Daunomac-20 Injection 1's may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, fever, chills, and pain at the site of injection. Most of these side effects of Daunomac-20 Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Daunomac-20 Injection 1's is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

Daunomac-20 Injection 1's should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Daunomac-20 Injection 1's. Daunomac-20 Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Daunomac-20 Injection 1's as it may increase the risk of liver damage. This medicine may be recommended for use in children only if the benefits outweigh the risks.

Uses of Daunomac-20 Injection 1's

Treatment of lymphocytic leukemia, and Acute non-lymphocytic leukemia

Medicinal Benefits

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Directions for Use

Your doctor will administer Daunomac-20 Injection 1's. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Daunomac-20 Injection 1's

  • Vomiting
  • Nausea
  • Mouth ulcers
  • Loss of appetite
  • Diarrhoea
  • Dizziness
  • Weakness
  • Injection site reactions
  • Pain at the site of injection

Drug Warnings

Daunomac-20 Injection 1's should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Daunomac-20 Injection 1's. Daunomac-20 Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Daunomac-20 Injection 1's as it may increase the risk of liver damage. Avoid excessive exposure to sunlight as Daunomac-20 Injection 1's may cause sensitivity to sunlight. You are advised to use sunscreen and wear protective clothing while going out. If you are about to receive any vaccinations, inform your doctor that you are taking Daunomac-20 Injection 1's as it may cause infections.

Drug Interactions

Drug-Drug Interactions: Daunomac-20 Injection 1's may interact with medicines used to treat ulcerative colitis (mesalazine, olsalazine), anti-inflammatory drugs (sulfasalazine), aminoglycosides (gentamicin, amikacin, neomycin), cholera vaccine, typhoid vaccine.

Drug-Food Interactions: Daunomac-20 Injection 1's may interact with alcohol. Therefore, avoid alcohol consumption with Daunomac-20 Injection 1's as it may increase the risk of liver damage.

Drug-Disease Interactions: Inform your doctor if you have liver or kidney disease before starting treatment with Daunomac-20 Injection 1's.

Drug-Drug Interactions Checker List

  • MESALAZINE
  • OLSALAZINE
  • SULFASALAZINE
  • GENTAMICIN
  • NEOMYCIN
  • AMIKACIN
  • CHOLERA VACCINE
  • TYPHOID VACCINE

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking Daunomac-20 Injection 1's as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking and alcohol consumption.

Special Advise

  • Regular blood tests are recommended while taking Daunomac-20 Injection 1's to monitor the number and type of cells in the blood and liver functioning.

Disease/Condition Glossary

Acute lymphocytic leukemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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Alcohol

Unsafe

Avoid consumption of alcohol with Daunomac-20 Injection 1's as it may increase the risk of liver damage.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving Daunomac-20 Injection 1's.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

Daunomac-20 Injection 1's causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Daunomac-20 Injection 1's.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Daunomac-20 Injection 1's can be recommended for acute lymphocytic leukemia in children. Please consult your doctor. Your child's doctor may prescribe a suitable dose based on the condition and age of your child. If this medicine is given, the child should be observed carefully for any unwanted effects.

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.
Other Info - DAU0013

FAQs

Daunomac-20 Injection 1's is used to treat lymphocytic leukemia, and Acute non-lymphocytic leukemia.
Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.
Daunomac-20 Injection 1's may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Daunomac-20 Injection 1's if you are planning to become a parent.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Daunomac-20 Injection 1's as it may cause infections.
Yes, Daunomac-20 Injection 1's is a vesicant (irritant) which means, it can cause severe tissue damage if it leaks into the surrounding tissues during injection (extravasation).
Daunomac-20 Injection 1's should be administered by the doctor or nurse through an intravenous route (into a vein). Do not self-administer.
The frequency and duration of treatment may vary depending on your medical condition being treated. Always follow the doctor's instructions regarding the dosing schedule to get full benefits.
The side effects of Daunomac-20 Injection 1's include mouth ulcers, diarrhoea, vomiting, nausea, loss of appetite, dizziness, weakness, fever, chills, and pain at the site of injection. Consult the doctor if any of these symptoms persist or worsen.

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