Domperidone+lansoprazole
About Domperidone+lansoprazole
Domperidone+lansoprazole belongs to a class of drugs called 'antacids' used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. Zollinger-Ellison syndrome is characterized by the formation of tumours in the upper part of the small intestine, which leads to excess acid production.
Domperidone+lansoprazole is a combination of two medicines, namely: 'Domperidone' and 'Lansoprazole'. Domperidone increases food movement in the stomach, which helps avoid the problems related to indigestion, bloating, and fullness. This medicine also restricts the action of a chemical that is responsible for the feeling of vomiting and nausea. On the other side, Lansoprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, Domperidone+lansoprazole reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. Thus, both medicines in combination provide relief from heartburn symptoms related to acid reflux.
Take Domperidone+lansoprazole as prescribed by your doctor. You are advised to take Domperidone+lansoprazole for as long as your doctor has prescribed it for you based on your medical condition. You may experience diarrhoea, nausea, vomiting, headache, dizziness, stomach pain, or constipation in some cases. Most of these side effects of Domperidone+lansoprazole do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Domperidone+lansoprazole or any other medicines, please tell your doctor. Domperidone+lansoprazole is not recommended for children as the safety and effectiveness were not established. If you are pregnant or breastfeeding, please inform your doctor before taking Domperidone+lansoprazole. Drive only if you are alert as Domperidone+lansoprazole may cause drowsiness. Avoid alcohol consumption as it may lead to increased stomach acid production, thereby increasing acidity and heartburn. Domperidone+lansoprazole is safe to be used by elderly persons, and no dosage adjustments are required.
Uses of Domperidone+lansoprazole
Medicinal Benefits
Domperidone+lansoprazole is suggested for the treatment of certain stomach related problems like ulcers and acid reflux. This medicine provides relief in heartburn and reduces the risk associated with acid's damage to the stomach and food pipe. It also reduces the risk of cancer of food pipe, a taste of acid in the mouth, chest pain, and teeth damage. Domperidone helps to increase the movement of the bowel in the intestine. It also treats vomiting and nausea caused by the usage of other medications. While Lansoprazole helps reduce frequent heartburn that happens for 2 or more days.
Directions for Use
Storage
Side Effects of Domperidone+lansoprazole
- Diarrhoea
- Nausea
- Vomiting
- Headache
- Dizziness
- Stomach pain
- Constipation
Drug Warnings
Inform your doctor if you have any risk factors for reduced vitamin B12 as Domperidone+lansoprazole may reduce the absorption of vitamin B12. If you get any skin rash, particularly in areas exposed to the sun or pain in joints, inform your doctor. If you get any skin rash, particularly in areas exposed to the sun or pain in joints, inform your doctor. If you are taking Domperidone+lansoprazole for more than one year, it may increase the risk of fracture of the spine, hip, or wrist. Drive only if you are alert as Domperidone+lansoprazole may cause drowsiness. Domperidone+lansoprazole may decrease magnesium levels in the blood, especially if taken for more than three months. Therefore, regular blood tests are recommended to monitor magnesium levels. If you experience bloody or watery diarrhoea with symptoms such as stomach pain, fever, or tenderness, contact your doctor immediately.
Drug Interactions
Drug-Drug Interactions: Domperidone+lansoprazole may interact with the anti-HIV drug (atazanavir), antifungals (ketoconazole, itraconazole), anticancer drug (methotrexate), heart-related medicine (digoxin), and blood thinner (warfarin).
Drug-Food Interactions: Domperidone+lansoprazole may interact with St. John’s wort (herbal supplement used to treat depression). Avoid alcohol consumption as alcohol intake leads to increased stomach acid production, thereby irritating the stomach lining and worsening the symptoms.
Drug-Disease Interactions: If you have a stomach tumor, liver problems, low magnesium levels in the blood, osteoporosis (weak and brittle bones), or lupus (an autoimmune disorder), inform your doctor before taking Domperidone+lansoprazole.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption as it may lead to increased production of stomach acid, thereby irritates the stomach lining and worsen the symptoms.
Pregnancy
cautionDomperidone+lansoprazole is a category B pregnancy drug and is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.
Breast Feeding
unsafeDomperidone+lansoprazole is usually contraindicated in breastfeeding mothers. Therefore, please consult a doctor before taking Domperidone+lansoprazole if you are breastfeeding.
Driving
cautionDomperidone+lansoprazole may cause drowsiness in some people. Therefore, avoid driving or operating machinery if you feel drowsy after taking Domperidone+lansoprazole.
Liver
cautionTake Domperidone+lansoprazole with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Domperidone+lansoprazole with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeDomperidone+lansoprazole is not recommended for children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Special Advise
- Regular blood tests are recommended while taking Domperidone+lansoprazole to monitor magnesium levels in the blood.
- Domperidone+lansoprazole may cause some abnormal liver enzyme and blood values. These changes are temporary and may return to normal after treatment with Domperidone+lansoprazole is discontinued.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers, and heartburn. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: These are sores that develop on the stomach and intestine lining due to erosion of the stomach protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Zollinger-Ellison syndrome: It is characterized by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Domperidone+lansoprazole is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Domperidone+lansoprazole is a combination of two medicines namely: "Domperidone" and "Lansoprazole". Domperidone increases the movement of food in the stomach which helps to avoid the problems related to indigestion, bloating, and fullness. This medicine also restricts the action of a chemical that is responsible for the feeling of vomiting and nausea. On the other side, Lansoprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, Domperidone+lansoprazole reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. Thus, both medicines in combination provide relief from heartburn symptoms related to acid reflux.
Domperidone+lansoprazole may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery or bloody stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Domperidone+lansoprazole to prevent dehydration.
Domperidone+lansoprazole may cause low levels of magnesium in the blood if taken for more than 3 months. If you experience involuntary muscle contractions, tiredness fits, increased heart rate or dizziness while taking Domperidone+lansoprazole, please consult a doctor immediately as these might be signs of low magnesium levels. However, regular blood tests are recommended to monitor magnesium levels in the blood while taking Domperidone+lansoprazole.
You are not recommended to take Domperidone+lansoprazole with antifungals such as ketoconazole or itraconazole as it may reduce the effectiveness of antifungal against fungal infections. However, please consult your doctor before taking Domperidone+lansoprazole with other medicines.
Domperidone+lansoprazole should be used with caution in osteoporosis (weak and brittle bones) patients as it may worsen the condition especially if Domperidone+lansoprazole is taken for more than 1 year as it increases the risk of fracture of the spine, hip or wrist. Therefore, inform your doctor if you have osteoporosis or take any steroids which may increase the risk of osteoporosis.
It is best to take whole grains food like brown rice, green vegetables, sweet potatoes, and carrots to reduce acidity.
Taking Domperidone+lansoprazole for longer than the duration recommended by your doctor may increase the risk of side effects. Prolonged use of Domperidone+lansoprazole may lead to heart-related issues due to domperidone. If taken for over a year, it may also result in hypomagnesemia (low magnesium levels), vitamin B12 deficiencies, bone fractures, and gut infections due to lansoprazole. Therefore, it is important to regularly monitor your health to determine whether you should continue taking Domperidone+lansoprazole. Always follow your doctor's advice and discuss any concerns about long-term use with them.
Yes, smoking and alcohol can increase acidity and contribute to GERD (Gastroesophageal Reflux Disease). Smoking is a major cause of GERD, while alcohol primarily triggers acid reflux episodes. Both smoking and alcohol can weaken the lower oesophageal sphincter, the muscle that keeps acid in the stomach, allowing it to flow back into the oesophagus. Smoking also reduces the amount of saliva that helps neutralize acid in the oesophagus, while alcohol can irritate the lining of both the stomach and the oesophagus. It is advisable to limit or avoid smoking and alcohol to help manage acidity and GERD.
The common side effects of Domperidone+lansoprazole include diarrhoea, nausea, vomiting, headache, dizziness, stomach pain, and constipation in some cases. Most of these side effects of Domperidone+lansoprazole do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
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