If you are allergic to ACETAMINOPHEN+TRAMADOL or any other medicines, please tell your doctor. ACETAMINOPHEN+TRAMADOL is not recommended for children below 12 years of age, as the safety and effectiveness were not established. Avoid taking ACETAMINOPHEN+TRAMADOL if you are pregnant as it may cause withdrawal symptoms in the newborn baby. ACETAMINOPHEN+TRAMADOL may be excreted in human milk. Please consult a doctor if you are breastfeeding. If you have fits, asthma, severe lung problems, drug dependence,  liver or kidney problems, inform your doctor before taking ACETAMINOPHEN+TRAMADOL. It is an offence to drive if ACETAMINOPHEN+TRAMADOL affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking ACETAMINOPHEN+TRAMADOL. Avoid alcohol consumption with ACETAMINOPHEN+TRAMADOL as it may increase drowsiness. Do not take ACETAMINOPHEN+TRAMADOL if you are taking pain relievers, sleeping pills, or taking medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Inform your doctor immediately if you experience any sleep-related breathing problems such as sleep apnoea (breathing stops and starts repeatedly) while taking ACETAMINOPHEN+TRAMADOL.

Drug-Drug Interactions: ACETAMINOPHEN+TRAMADOL may interact with anticonvulsants (carbamazepine, pregabalin), opioid pain killers (pentazocine, buprenorphine, nalbuphine, morphine), cough medication (codeine), muscle relaxant (baclofen), blood thinners (warfarin, phenprocoumon), antiemetic drugs (ondansetron, metoclopramide, domperidone), high cholesterol lowering medicine (cholestyramine), sedative-hypnotics (zolpidem), pain relievers (celecoxib), antidepressants (duloxetine, escitalopram), and anti-anxiety drugs (alprazolam).

Drug- Food Interactions: Avoid foods rich in carbohydrates, pectin including jellies, cabbage, Brussels sprouts and broccoli as ACETAMINOPHEN+TRAMADOL may interact with these foods. ACETAMINOPHEN+TRAMADOL may interact with grapefruit juice. Therefore, avoid intake of grapefruit juice with ACETAMINOPHEN+TRAMADOL as it may increase ACETAMINOPHEN+TRAMADOL levels in the body. Also, avoid alcohol consumption while taking ACETAMINOPHEN+TRAMADOL as it may increase drowsiness.

Drug-Disease Interactions: If you have fits, asthma, severe lung problems, severe headaches associated with vomiting, drug dependence,  liver or kidney problems or if you have recently suffered from shock or head injury, inform your doctor before taking ACETAMINOPHEN+TRAMADOL.

• Do regular exercises such as swimming or walking.
• Drink plenty of water while taking ACETAMINOPHEN+TRAMADOL to avoid dry mouth.
• Maintain a fibre rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while taking ACETAMINOPHEN+TRAMADOL.
• Avoid consumption of alcohol and quit smoking.

• Patients with severe liver or kidney insufficiency should avoid taking ACETAMINOPHEN+TRAMADOL.
• Do not give ACETAMINOPHEN+TRAMADOL to others. Use ACETAMINOPHEN+TRAMADOL only when prescribed by a doctor and avoid frequent or high doses as it may cause addiction.
• Please do not stop taking ACETAMINOPHEN+TRAMADOL suddenly as it may cause withdrawal symptoms such as difficulty in sleeping, anxiety, nervousness, shaking, stomach or bowel disorders or make you overactive. Therefore, take ACETAMINOPHEN+TRAMADOL for as long as your doctor has prescribed it.