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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xostiv 500 Tablet 60's is used in combination with prednisone or prednisolone to treat prostate cancer in adult men that has spread to other body parts. It contains Abiraterone, which works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is not for use in women, children, and adolescents. In some cases, Xostiv 500 Tablet 60's may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

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Whats That

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Synonym :

ABIRATERONE ACETATE

Composition :

ABIRATERONE-500MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Xostiv 500 Tablet 60's

Xostiv 500 Tablet 60's belongs to the group of medicines called androgen biosynthesis inhibitors that is indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts.

Xostiv 500 Tablet 60's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

In some cases, Xostiv 500 Tablet 60's may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

Xostiv 500 Tablet 60's is not for use in women, children, and adolescents. Xostiv 500 Tablet 60's should not be given in combination with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Xostiv 500 Tablet 60's

Treatment of Prostate cancer

Directions for Use

Take this medicine on an empty stomach, i.e., 1 hour before or 2 hours after food. Swallow Xostiv 500 Tablet 60's as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Xostiv 500 Tablet 60's belongs to the group of medicines called androgen biosynthesis inhibitors, indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts. Xostiv 500 Tablet 60's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is indicated in patients with metastatic castration-resistant prostate cancer (CRPC) who have received prior chemotherapy containing docetaxel and metastatic high-risk castration-sensitive prostate cancer (CSPC). Xostiv 500 Tablet 60's is prescribed in the early stages of the disease, where it is still responding to hormone therapy. It is used with androgen deprivation therapy (a treatment that lowers testosterone).

How Xostiv 500 Tablet 60's Works

Xostiv 500 Tablet 60's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xostiv 500 Tablet 60's

  • Diarrhoea
  • Low blood potassium
  • High blood pressure
  • Urinary tract infection
  • Oedema (fluid in legs or feet)

What if I have taken an overdose of Xostiv 500 Tablet 60's

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Xostiv 500 Tablet 60's may include fast or irregular heartbeat, lightheadedness, dizziness, or fainting, shortness of breath or difficulty breathing, swelling of the feet, ankles, or lower legs, and unexplained weight gain. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Xostiv 500 Tablet 60's if you are allergic to any of its components, if you have severe liver damage, or in combination with Ra-233 (used to treat prostate cancer). Inform your doctor if you have liver problems, high blood pressure, low blood potassium, heart failure, heart or blood vessel problems, irregular or rapid heartbeat, heart rhythm problems, shortness of breath, rapid weight gain, swelling in the legs, ankles, or feet, high blood sugar, bone problems, or if you have taken ketoconazole in the past for prostate cancer. Xostiv 500 Tablet 60's may cause libido (decreased sex drive), muscle weakness, decreased red blood cells, and/or muscle pain. Xostiv 500 Tablet 60's should not be given in combination with Ra-233 due to an increased risk of bone fracture or death.

Drug-Drug Interactions

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AbirateroneEliglustat
Critical
AbirateroneZiprasidone
Critical

Drug-Drug Interactions

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AbirateroneEliglustat
Critical
How does the drug interact with Xostiv 500 Tablet 60's:
Coadministration of Xostiv 500 Tablet 60's with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneZiprasidone
Critical
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Xostiv 500 Tablet 60's and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AbirateroneMesoridazine
Critical
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneThioridazine
Critical
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneHydrocodone
Severe
How does the drug interact with Xostiv 500 Tablet 60's:
Coadministration of Xostiv 500 Tablet 60's with Hydrocodone can increase the levels of Hydrocodone in the body. This increases the risk or severity of side effects like low blood pressure, and low respiratory rate.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's with Hydrocodone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, difficulty concentrating, impairment in thinking and judgment, fainting, confusion, excessive drowsiness, slow heart rate, and shallow or difficult breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbirateronePasireotide
Severe
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with Pasireotide can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's with Pasireotide together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneVemurafenib
Severe
How does the drug interact with Xostiv 500 Tablet 60's:
Taking Xostiv 500 Tablet 60's with Vemurafenib can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's with Vemurafenib together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneMifepristone
Severe
How does the drug interact with Xostiv 500 Tablet 60's:
Using mifepristone together with Xostiv 500 Tablet 60's can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Xostiv 500 Tablet 60's with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience symptoms such as nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heartbeat, or chest pain. Do not discontinue any medications without consulting a doctor.
AbirateroneCarbamazepine
Severe
How does the drug interact with Xostiv 500 Tablet 60's:
Taking carbamazepine and Xostiv 500 Tablet 60's together may reduce the blood level of Xostiv 500 Tablet 60's.

How to manage the interaction:
Taking carbamazepine and Xostiv 500 Tablet 60's together can result in an interaction, it can be taken if your doctor has advised it. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Xostiv 500 Tablet 60's Substitute

Substitutes safety advice
  • Samtica 500 mg Tablet 60's

    423.67per tablet
  • Abiratred Tablet 60's

    191.33per tablet
  • Alkeprost 500 mg Tablet 60's

    191.32per tablet
  • Mytera 500 mg Tablet 60's

    245.86per tablet
  • Uniprost 500 mg Tablet 60's

    541.67per tablet
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Alcohol

Consult your doctor

It is unknown if alcohol affects Xostiv 500 Tablet 60's. Please consult your doctor.

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Pregnancy

Unsafe

Xostiv 500 Tablet 60's is not for use in women.

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Breast Feeding

Not applicable

Xostiv 500 Tablet 60's is not for use in women.

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Driving

Safe if prescribed

Xostiv 500 Tablet 60's is not likely to affect your ability to drive or operate machinery.

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Liver

Caution

Do not take Xostiv 500 Tablet 60's if you have severe liver damage. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns.

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Children

Not applicable

Xostiv 500 Tablet 60's is not for use in children and adolescents.

FAQs

Xostiv 500 Tablet 60's is used to treat Prostate cancer.
Xostiv 500 Tablet 60's works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.
Prednisolone/prednisone is prescribed along with Xostiv 500 Tablet 60's to lower the chances of getting high blood pressure, fluid retention (having too much water in the body), or low blood potassium levels.
Xostiv 500 Tablet 60's should not be given along with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. If you are prescribed to take Ra-233 following treatment with Xostiv 500 Tablet 60's and prednisolone/prednisone, you must wait five days before starting treatment with Ra-233.
No, Xostiv 500 Tablet 60's cannot cure prostate cancer. However, it is used to manage advanced or metastatic prostate cancer that works by inhibiting the production of testosterone, thereby preventing the growth and spread of cancer.
No, Xostiv 500 Tablet 60's is not a chemotherapy drug. It is a hormone therapy medication, which reduces testosterone levels to help manage prostate cancer.
Yes, Xostiv 500 Tablet 60's may affect the liver. Therefore, the doctor may advise regular blood tests to monitor its effects on the liver.
For patients taking Xostiv 500 Tablet 60's liver investigations are recommended. However, the frequency may differ for each individual and can be determined by the doctor based on your medical condition.
Xostiv 500 Tablet 60's can be taken orally on an empty stomach, either 1 hour before a meal or 2 hours after the meal. Swallow it as a whole with a glass of water. Do not chew or break it.
The side effects of Xostiv 500 Tablet 60's include oedema, urinary tract infection, high blood pressure, low blood potassium, and diarrhoea. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - XOS0003

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