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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Trilith 450mg Tablet SR belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Manufacturer/Marketer :

Triton Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Trilith 450mg Tablet SR

Trilith 450mg Tablet SR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Trilith 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Trilith 450mg Tablet SR as prescribed. Your doctor will advise you on how often you need to take Trilith 450mg Tablet SR based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Trilith 450mg Tablet SR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Trilith 450mg Tablet SR or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Trilith 450mg Tablet SR. Regular blood tests are recommended while taking Trilith 450mg Tablet SR to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Trilith 450mg Tablet SR.

Uses of Trilith 450mg Tablet SR

Treatment of Bipolar disorder and Mania

Directions for Use

Take Trilith 450mg Tablet SR with food for better absorption or take it as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Trilith 450mg Tablet SR is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Trilith 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Trilith 450mg Tablet SR relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Trilith 450mg Tablet SR Works

Trilith 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trilith 450mg Tablet SR

  • Loss of appetite
  • Dizziness
  • Dry mouth
  • Taste change
  • Diarrhoea
  • Blurred vision
  • Slurred speech
  • Shaky movements
  • Increased thirst and urination

What if I have taken an overdose of Trilith 450mg Tablet SR

Take Trilith 450mg Tablet SR only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Trilith 450mg Tablet SR to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Trilith 450mg Tablet SR. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Trilith 450mg Tablet SR as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Trilith 450mg Tablet SR:
Cidofovir can cause higher levels of Trilith 450mg Tablet SR carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Trilith 450mg Tablet SR with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Trilith 450mg Tablet SR:
Taking Cisapride with Trilith 450mg Tablet SR can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Trilith 450mg Tablet SR with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumChloroquine
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking chloroquine with Trilith 450mg Tablet SR together can increase the risk ofabnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Trilith 450mg Tablet SR together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumEverolimus
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR with Everolimus may increase the risk of kidney problems.

How to manage the interaction:
Although taking Everolimus and Trilith 450mg Tablet SR together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
LithiumParoxetine
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Combining Paroxetine with Trilith 450mg Tablet SR carbonate can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Paroxetine and Trilith 450mg Tablet SR together can evidently cause an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumDolasetron
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR with Dolasetron can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Dolasetron and Trilith 450mg Tablet SR, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumTrazodone
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Combining Trilith 450mg Tablet SR carbonate with Trazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Trazodone and Trilith 450mg Tablet SR, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumIndapamide
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Indapamide with Trilith 450mg Tablet SR can increase the blood levels of Trilith 450mg Tablet SR.

How to manage the interaction:
Taking Indapamide with Trilith 450mg Tablet SR can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, consult a doctor. Do not discontinue any medications without a doctor's advice.
LithiumPolythiazide
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Polythiazide with Trilith 450mg Tablet SR may increase the blood levels of Trilith 450mg Tablet SR.

How to manage the interaction:
Although taking Polythiazide and Trilith 450mg Tablet SR together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
LithiumAmiodarone
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Co-administration of Amiodarone together with Trilith 450mg Tablet SR may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Trilith 450mg Tablet SR interact, they can be used if prescribed by a doctor. If you have heart problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Trilith 450mg Tablet SR.
  • Do regular exercise and maintain a stable weight as Trilith 450mg Tablet SR may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Trilith 450mg Tablet SR Substitute

Substitutes safety advice
  • LITHONEX XL 450MG TABLET

    11.70per tablet
  • Lithic SR 450 mg Tablet 10's

    5.40per tablet
  • Lith-450 PR Tablet 10's

    6.30per tablet
  • Manicarb SR 450 Tablet 10's

    6.30per tablet
  • Lidowel CR 450 Tablet 10's

    10.80per tablet
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Trilith 450mg Tablet SR as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Trilith 450mg Tablet SR is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Trilith 450mg Tablet SR as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Trilith 450mg Tablet SR may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Trilith 450mg Tablet SR.

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Liver

Safe if prescribed

Trilith 450mg Tablet SR is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Trilith 450mg Tablet SR with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Trilith 450mg Tablet SR is not recommended for patients with severe kidney problems.

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Children

Caution

Trilith 450mg Tablet SR is generally not recommended for children below 12 years. However, Trilith 450mg Tablet SR may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

FAQs

Trilith 450mg Tablet SR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.
Trilith 450mg Tablet SR helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.
Trilith 450mg Tablet SR is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Trilith 450mg Tablet SR.
Trilith 450mg Tablet SR may cause weight gain but it is not necessary for everyone taking Trilith 450mg Tablet SR to experience this side effect. However, in order to avoid gaining weight while taking Trilith 450mg Tablet SR, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.
It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.
Trilith 450mg Tablet SR may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Trilith 450mg Tablet SR to avoid dehydration.
You are not recommended to stop taking Trilith 450mg Tablet SR without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Trilith 450mg Tablet SR for as long as your doctor has prescribed it and if you experience any difficulty while taking Trilith 450mg Tablet SR, please consult your doctor so that the dose may be gradually reduced.
You are not recommended to take Trilith 450mg Tablet SR with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Trilith 450mg Tablet SR with any other medicines, you are advised to contact your doctor.
The effects of Trilith 450mg Tablet SR can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Trilith 450mg Tablet SR regularly as prescribed by your doctor to maintain its effectiveness.
It's important to inform your doctor about your hypertension and the medications you're taking for it as Trilith 450mg Tablet SR can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.
No, you should not increase the dose of Trilith 450mg Tablet SR on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.
Yes, Trilith 450mg Tablet SR can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
Yes, Trilith 450mg Tablet SR can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Trilith 450mg Tablet SR.
Trilith 450mg Tablet SR should only be started if adequate facilities for assessing Trilith 450mg Tablet SR levels are available. Because elevated levels of Trilith 450mg Tablet SR are linked to Trilith 450mg Tablet SR toxicity. Trilith 450mg Tablet SR toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Trilith 450mg Tablet SR levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Trilith 450mg Tablet SR should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Trilith 450mg Tablet SR may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
Certain medications which decrease the levels of Trilith 450mg Tablet SR in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Trilith 450mg Tablet SR, inform your doctor about all the medicines you are taking.
The common side effects of Trilith 450mg Tablet SR are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - TR96504

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