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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Lithonex XL 450 mg Tablet belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Manufacturer/Marketer :

Theo Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lithonex XL 450 mg Tablet

Lithonex XL 450 mg Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lithonex XL 450 mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lithonex XL 450 mg Tablet as prescribed. Your doctor will advise you on how often you need to take Lithonex XL 450 mg Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lithonex XL 450 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lithonex XL 450 mg Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lithonex XL 450 mg Tablet . Regular blood tests are recommended while taking Lithonex XL 450 mg Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lithonex XL 450 mg Tablet .

Uses of Lithonex XL 450 mg Tablet

Treatment of Bipolar disorder and Mania

Directions for Use

Take Lithonex XL 450 mg Tablet with food for better absorption or take it as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Lithonex XL 450 mg Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lithonex XL 450 mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lithonex XL 450 mg Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Lithonex XL 450 mg Tablet Works

Lithonex XL 450 mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lithonex XL 450 mg Tablet

  • Loss of appetite
  • Dizziness
  • Dry mouth
  • Taste change
  • Diarrhoea
  • Blurred vision
  • Slurred speech
  • Shaky movements
  • Increased thirst and urination

What if I have taken an overdose of Lithonex XL 450 mg Tablet

Take Lithonex XL 450 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Lithonex XL 450 mg Tablet to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lithonex XL 450 mg Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lithonex XL 450 mg Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Taking Cisapride with Lithonex XL 450 mg Tablet 10's can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithonex XL 450 mg Tablet 10's with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Cidofovir can cause higher levels of Lithonex XL 450 mg Tablet 10's carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithonex XL 450 mg Tablet 10's with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumMoxifloxacin
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Using Moxifloxacin together with Lithonex XL 450 mg Tablet 10's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Moxifloxacin with Lithonex XL 450 mg Tablet 10's can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience dizziness, shortness of breath, or heart palpitations Do not discontinue any medications without consulting a doctor.
LithiumHydrochlorothiazide
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Coadministration of Lithonex XL 450 mg Tablet 10's and Hydrochlorothiazide can increase the effects of Lithonex XL 450 mg Tablet 10's.

How to manage the interaction:
Taking Lithonex XL 450 mg Tablet 10's and Hydrochlorothiazide together can possibly result in an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Lithiumchlorthalidone
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Co-administration of chlorthalidone together with Lithonex XL 450 mg Tablet 10's can increase the effects of Lithonex XL 450 mg Tablet 10's.

How to manage the interaction:
Although there is a interaction between chlorthalidone and Lithonex XL 450 mg Tablet 10's, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
LithiumCitalopram
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Taking Lithonex XL 450 mg Tablet 10's with Citalopram can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Citalopram and Lithonex XL 450 mg Tablet 10's, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumDeferasirox
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Taking deferasirox with Lithonex XL 450 mg Tablet 10's may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Lithonex XL 450 mg Tablet 10's and Deferasirox, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
LithiumDolasetron
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Taking Lithonex XL 450 mg Tablet 10's with Dolasetron can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Dolasetron and Lithonex XL 450 mg Tablet 10's, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumMoexipril
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Taking Lithonex XL 450 mg Tablet 10's with Moexipril may significantly increase the blood levels of Lithonex XL 450 mg Tablet 10's.

How to manage the interaction:
Co-administration of Lithonex XL 450 mg Tablet 10's with Moexipril can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, or increased urination contact a doctor. Do not stop using any medications without a doctor's advice.
LithiumSirolimus
Severe
How does the drug interact with Lithonex XL 450 mg Tablet 10's:
Coadministration of Sirolimus with Lithonex XL 450 mg Tablet 10's together may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Lithonex XL 450 mg Tablet 10's and Sirolimus together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lithonex XL 450 mg Tablet .
  • Do regular exercise and maintain a stable weight as Lithonex XL 450 mg Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lithonex XL 450 mg Tablet Substitute

Substitutes safety advice
  • Manicarb SR 450 Tablet 10's

    6.30per tablet
  • Lithic SR 450 mg Tablet 10's

    5.40per tablet
  • Lith-450 PR Tablet 10's

    6.30per tablet
  • Lidowel CR 450 Tablet 10's

    10.80per tablet
  • Olith SR-450 Tablet 10's

    7.20per tablet
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lithonex XL 450 mg Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

bannner image

Pregnancy

Unsafe

Lithonex XL 450 mg Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lithonex XL 450 mg Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Lithonex XL 450 mg Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lithonex XL 450 mg Tablet .

bannner image

Liver

Safe if prescribed

Lithonex XL 450 mg Tablet is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Lithonex XL 450 mg Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lithonex XL 450 mg Tablet is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Lithonex XL 450 mg Tablet is generally not recommended for children below 12 years. However, Lithonex XL 450 mg Tablet may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

FAQs

Lithonex XL 450 mg Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.
Lithonex XL 450 mg Tablet helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.
Lithonex XL 450 mg Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lithonex XL 450 mg Tablet .
Lithonex XL 450 mg Tablet may cause weight gain but it is not necessary for everyone taking Lithonex XL 450 mg Tablet to experience this side effect. However, in order to avoid gaining weight while taking Lithonex XL 450 mg Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.
It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.
Lithonex XL 450 mg Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lithonex XL 450 mg Tablet to avoid dehydration.
You are not recommended to stop taking Lithonex XL 450 mg Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lithonex XL 450 mg Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Lithonex XL 450 mg Tablet , please consult your doctor so that the dose may be gradually reduced.
You are not recommended to take Lithonex XL 450 mg Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lithonex XL 450 mg Tablet with any other medicines, you are advised to contact your doctor.
The effects of Lithonex XL 450 mg Tablet can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Lithonex XL 450 mg Tablet regularly as prescribed by your doctor to maintain its effectiveness.
It's important to inform your doctor about your hypertension and the medications you're taking for it as Lithonex XL 450 mg Tablet can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.
No, you should not increase the dose of Lithonex XL 450 mg Tablet on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.
Yes, Lithonex XL 450 mg Tablet can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
Yes, Lithonex XL 450 mg Tablet can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lithonex XL 450 mg Tablet .
Lithonex XL 450 mg Tablet should only be started if adequate facilities for assessing Lithonex XL 450 mg Tablet levels are available. Because elevated levels of Lithonex XL 450 mg Tablet are linked to Lithonex XL 450 mg Tablet toxicity. Lithonex XL 450 mg Tablet toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithonex XL 450 mg Tablet levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Lithonex XL 450 mg Tablet should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lithonex XL 450 mg Tablet may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
Certain medications which decrease the levels of Lithonex XL 450 mg Tablet in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lithonex XL 450 mg Tablet , inform your doctor about all the medicines you are taking.
The common side effects of Lithonex XL 450 mg Tablet are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Theo Pharma Pvt Ltd, 401, Sachet-3, Mirambica School Road, Naranpura, Naranpura
Other Info - LIT0057

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