Lith-450 PR Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lith-450 PR Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lith-450 PR Tablet as prescribed. Your doctor will advise you on how often you need to take Lith-450 PR Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lith-450 PR Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lith-450 PR Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lith-450 PR Tablet . Regular blood tests are recommended while taking Lith-450 PR Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lith-450 PR Tablet .

Lith-450 PR Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lith-450 PR Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lith-450 PR Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

• Loss of appetite
• Dizziness
• Dry mouth
• Taste change
• Diarrhoea
• Blurred vision
• Slurred speech
• Shaky movements
• Increased thirst and urination

Regular blood tests are recommended while taking Lith-450 PR Tablet to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lith-450 PR Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lith-450 PR Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interaction: Lith-450 PR Tablet may have interaction with high blood pressure-lowering medicines (ramipril, lisinopril, methyldopa, amlodipine, diltiazem), pain killers (ibuprofen, diclofenac, celecoxib, indomethacin), asthma drugs (theophylline), antipsychotics (olanzapine, haloperidol, clozapine, sertindole), fits related drugs (phenytoin, clonazepam, carbamazepine), heart-related medicines (quinidine, amiodarone, propafenone, ranolazine, procainamide, disopyramide, hydroquinidine, ibutilide, sotalol, dofetilide), antidepressants (paroxetine, amitriptyline, fluoxetine), antibiotics (trimethoprim, spectinomycin, metronidazole, tetracycline).

Drug-Food Interaction: Lith-450 PR Tablet may interact with caffeine. Therefore, reduce the intake of caffeine including coffee, tea, or herbal medicines as it may decrease the effect of Lith-450 PR Tablet . Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty in concentrating. Intake of sodium may also alter lithium levels. Hence, maintain a constant dietary intake of salt.

Drug-Disease Interaction: If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, Brugada syndrome (a hereditary syndrome affecting the heart), hypothyroidism (low thyroid levels), and low sodium levels, inform your doctor before taking Lith-450 PR Tablet .

• RAMIPRIL
• LISINOPRIL
• METHYLDOPA
• AMLODIPINE
• DILTIAZEM
• IBUPROFEN
• DICLOFENAC
• CELECOXIB
• INDOMETHACIN
• THEOPHYLLINE
• OLANZAPINE
• HALOPERIDOL
• CLOZAPINE
• SERTINDOLE
• PHENYTOIN
• CLONAZEPAM
• CARBAMAZEPINE
• QUINIDINE
• AMIODARONE
• PROPAFENONE
• RANOLAZINE
• PROCAINAMIDE
• DISOPYRAMIDE
• HYDROQUINIDINE
• IBUTILIDE
• SOTALOL
• DOFETILIDE
• PAROXETINE
• AMITRIPTYLINE
• FLUOXETINE
• TRIMETHOPRIM
• SPECTINOMYCIN
• METRONIDAZOLE
• TETRACYCLINE

• Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
• Limit the intake of caffeine as it may reduce the effectiveness of Lith-450 PR Tablet .
• Do regular exercise and maintain a stable weight as Lith-450 PR Tablet may cause weight gain.
• Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
• Avoid consumption of alcohol as it may increase drowsiness.

• Regular blood tests are advised every week while taking Lith-450 PR Tablet to monitor the levels of lithium in blood. When lithium levels are constant, blood tests may be done every 3 months.
• Drink a constant amount of water daily and maintain a constant sodium intake as any major changes in these two may alter the levels of lithium in blood.

Mania: It is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Mania may occur due to lack of sleep or changes in sleep pattern, high levels of stress, and alcohol intake. Seek medical help immediately if you have any self-harming or suicidal thoughts.

Bipolar disorder: It is also called manic depression, a mental condition associated with extreme mood swings ranging from manic highs to depressive lows. The symptoms of bipolar disorder include mania (high energy and excitability) and depression (loss of interest, hopelessness, and low energy). Bipolar disorder involves lifelong treatment.