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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nt Grain Tablet is indicated to treat and prevent migraine. It is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. It narrows the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Also, it prevents nausea and vomiting associated with migraine. It may cause common side effects, such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping).
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Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Nt Grain Tablet

Nt Grain Tablet is indicated to treat and prevent migraine. Nt Grain Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by an intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Nt Grain Tablet is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Nt Grain Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Nt Grain Tablet contains paracetamol; do not take other medicines containing paracetamol along with Nt Grain Tablet unless prescribed. Do not take Nt Grain Tablet if you are pregnant or breastfeeding. Nt Grain Tablet may cause drowsiness and dizziness, so drive with caution. Nt Grain Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Nt Grain Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Nt Grain Tablet

Treatment of Migraine.

Directions for Use

Take Nt Grain Tablet with or without food. Swallow Nt Grain Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Nt Grain Tablet is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Nt Grain Tablet is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Nt Grain Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

How Nt Grain Tablet Works

Nt Grain Tablet is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nt Grain Tablet

  • Stomach upset
  • Dizziness
  • Dry mouth
  • Constipation
  • Insomnia (trouble sleeping)

What if I have taken an overdose of Nt Grain Tablet

Do not take more than the prescribed dose of Nt Grain Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Nt Grain Tablet if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Nt Grain Tablet , when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Nt Grain Tablet contains paracetamol, do not take other medicines containing paracetamol along with Nt Grain Tablet unless prescribed. Inform your doctor before taking Nt Grain Tablet if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Nt Grain Tablet if you are pregnant or breastfeeding. Nt Grain Tablet may cause drowsiness and dizziness, so drive only if you are alert. Nt Grain Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Nt Grain Tablet as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Nt Grain Tablet unless prescribed. 

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical
ProchlorperazineMetoclopramide
Critical

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical
How does the drug interact with Nt Grain Tablet 10's:
Coadministration of mesoridazine and Nt Grain Tablet 10's can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Nt Grain Tablet 10's is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
ProchlorperazineMetoclopramide
Critical
How does the drug interact with Nt Grain Tablet 10's:
Coadministration of metoclopramide and Nt Grain Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Nt Grain Tablet 10's together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
CaffeineLinezolid
Critical
How does the drug interact with Nt Grain Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Nt Grain Tablet 10's with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Nt Grain Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Nt Grain Tablet 10's with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Nt Grain Tablet 10's:
Coadministration of tranylcypromine with Nt Grain Tablet 10's can in cause severe high blood pressure.

How to manage the interaction:
Taking Nt Grain Tablet 10's with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Nt Grain Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Nt Grain Tablet 10's with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
ErgotamineSafinamide
Critical
How does the drug interact with Nt Grain Tablet 10's:
Taking Safinamide with Nt Grain Tablet 10's can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Nt Grain Tablet 10's is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
ErgotamineItraconazole
Critical
How does the drug interact with Nt Grain Tablet 10's:
The blood levels and effects of Nt Grain Tablet 10's may be greatly increased when combined with itraconazole.

How to manage the interaction:
Nt Grain Tablet 10's and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you experience a severe headache, shortness of breath, blurred vision, confusion, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of the fingers or toes, pale or cold skin, or chest pain or tightness. Without first consulting your doctor, never stop taking medicines.
ErgotamineCeritinib
Critical
How does the drug interact with Nt Grain Tablet 10's:
Taking Nt Grain Tablet 10's with ceritinib can significantly increase the blood levels and effects of Nt Grain Tablet 10's.

How to manage the interaction:
Taking Ceritinib with Nt Grain Tablet 10's is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
ErgotamineTranylcypromine
Critical
How does the drug interact with Nt Grain Tablet 10's:
Coadministration of Nt Grain Tablet 10's and Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Nt Grain Tablet 10's is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Avoid bright lights, loud noise, and extreme temperatures.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Massage your scalp to ease the pain.

  • Lie down in a quiet, dark room.

  • Avoid smoking, alcohol, and caffeinated drinks. 

  • Learn what triggers your migraine and try avoiding them.

  • Stay hydrated. Drink plenty of fluids.

  • Learn relaxation skills as they help in reducing stress.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Nt Grain Tablet Substitute

Substitutes safety advice
  • Vasograin Tablet 14's

    8.68per tablet
  • Vasograin Tablet 20's

    10.55per tablet
  • Migrafen Tablet 10's

    10.80per tablet
  • Migrarest Tablet 10's

    8.42per tablet
  • Migrapac Tablet 10's

    7.34per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nt Grain Tablet as it may cause increased drowsiness.

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Pregnancy

Unsafe

Avoid taking Nt Grain Tablet if you are pregnant or planning for pregnancy. Please consult your doctor if you are pregnant or if you have any concerns regarding this.

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Breast Feeding

Unsafe

Nt Grain Tablet may pass into breastmilk. Avoid taking Nt Grain Tablet if you are breastfeeding.

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Driving

Caution

Nt Grain Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Nt Grain Tablet should not be given to children as the safety and effectiveness were not established.

FAQs

Nt Grain Tablet is used to treat and prevent migraine. It is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.
Nt Grain Tablet contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
Dry mouth could be a side-effect of Nt Grain Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Orthostatic hypotension could be a side-effect of Nt Grain Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.
Do not discontinue Nt Grain Tablet without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking Nt Grain Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Nt Grain Tablet .
Do not take Nt Grain Tablet along with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). Nt Grain Tablet contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain.
Nt Grain Tablet may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - NTG0002

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