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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefumide-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefumide-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lefumide-20 Tablet

Lefumide-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefumide-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefumide-20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefumide-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefumide-20 Tablet if you are pregnant or planning for pregnancy, as Lefumide-20 Tablet may cause serious congenital disabilities. Lefumide-20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefumide-20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefumide-20 Tablet as it could lead to increased dizziness and liver damage. Lefumide-20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefumide-20 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefumide-20 Tablet with or without food. Swallow Lefumide-20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefumide-20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefumide-20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefumide-20 Tablet Works

Lefumide-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefumide-20 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefumide-20 Tablet

Do not take more than the prescribed dose of Lefumide-20 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefumide-20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefumide-20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefumide-20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefumide-20 Tablet may cause dizziness, so drive with caution. Lefumide-20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideCarbamazepine
Severe
LeflunomideHydroxychloroquine
Severe

Drug-Drug Interactions

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LeflunomideCarbamazepine
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Taking carbamazepine and Lefumide-20 Tablet 10's may increase the risk of liver problems.

How to manage the interaction:
Although taking carbamazepine and Lefumide-20 Tablet 10's together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, yellowing of the skin or eyes, consult your doctor. Do not stop using any medication without consulting your doctor.
LeflunomideHydroxychloroquine
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
The combined use of Lefumide-20 Tablet 10's and Hydroxychloroquine can increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. This can develop anemia, bleeding problems, or infections.

How to manage the interaction:
Co-administration of Lefumide-20 Tablet 10's and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination., consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideIbrutinib
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Co-administration of Ibrutinib and Lefumide-20 Tablet 10's can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrutinib can be taken with Lefumide-20 Tablet 10's, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideBexarotene
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Combining Bexarotene with Lefumide-20 Tablet 10's can increase the risk of negative side effects.

How to manage the interaction:
Although taking Lefumide-20 Tablet 10's and Bexarotene together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - liver problems, complications, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideItraconazole
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Co-administration of Lefumide-20 Tablet 10's and itraconazole can raise the risk of liver problems.

How to manage the interaction:
Lefumide-20 Tablet 10's and itraconazole may interact, but if a doctor prescribes them, you can still use them. If you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, weakness, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, then you must visit a doctor. Never discontinue taking a drug without consulting a doctor.
LeflunomidePrednisolone
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Co-administration of Lefumide-20 Tablet 10's with Prednisolone may raise the risk of serious infection.

How to manage the interaction:
Although taking Lefumide-20 Tablet 10's and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideRosuvastatin
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Co-administration of Lefumide-20 Tablet 10's and rosuvastatin can increase the risk of developing liver problems.

How to manage the interaction:
Co-administration of Lefumide-20 Tablet 10's and Rosuvastatin can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideDisulfiram
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Coadministration of Disulfiram and Lefumide-20 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Disulfiram and Lefumide-20 Tablet 10's, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, vomiting, stomach pain, dark urine, or yellowing of skin and eyes, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
LeflunomideDuloxetine
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Coadministration of duloxetine and Lefumide-20 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Although taking Duloxetine with Cyclobenzaprine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, itching, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LeflunomideTacrolimus
Severe
How does the drug interact with Lefumide-20 Tablet 10's:
Taking Lefumide-20 Tablet 10's together with tacrolimus may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and Lefumide-20 Tablet 10's together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefumide-20 Tablet Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

    25.83per tablet
  • Lefra 20 Tablet 10's

    26.37per tablet
  • Rumalef 20 Tablet 30's

    17.90per tablet
  • Cleft 20 Tablet 10's

    21.83per tablet
  • DM Lef 20 mg Tablet 10's

    24.48per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefumide-20 Tablet . Alcohol intake, along with Lefumide-20 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefumide-20 Tablet while you are pregnant. Lefumide-20 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefumide-20 Tablet while you are breastfeeding. Lefumide-20 Tablet passes into breast milk.

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Driving

Caution

Lefumide-20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefumide-20 Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefumide-20 Tablet .

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Children

Unsafe

Lefumide-20 Tablet is not approved for children under the age of 18 years.

FAQs

Lefumide-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
Lefumide-20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).
Lefumide-20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefumide-20 Tablet . Take Lefumide-20 Tablet for as long as your doctor has prescribed to treat your condition effectually.
Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - LEF0006

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