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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefno-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lefno-20 Tablet

Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefno-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefno-20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefno-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefno-20 Tablet if you are pregnant or planning for pregnancy, as Lefno-20 Tablet may cause serious congenital disabilities. Lefno-20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefno-20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefno-20 Tablet as it could lead to increased dizziness and liver damage. Lefno-20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefno-20 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefno-20 Tablet with or without food. Swallow Lefno-20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefno-20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefno-20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefno-20 Tablet Works

Lefno-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefno-20 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefno-20 Tablet

Do not take more than the prescribed dose of Lefno-20 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefno-20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefno-20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefno-20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefno-20 Tablet may cause dizziness, so drive with caution. Lefno-20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideMitomycin
Severe
LeflunomideCapecitabine
Severe

Drug-Drug Interactions

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LeflunomideMitomycin
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Using Lefno-20 Tablet 10's together with mitomycin may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Lefno-20 Tablet 10's with Mitomycin can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor immediately if you experience symptoms such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideCapecitabine
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Co-administration of Lefno-20 Tablet 10's with Capecitabine may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, capecitabine can be taken with Lefno-20 Tablet 10's if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
LeflunomideLamivudine
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Combining Lamivudine with Lefno-20 Tablet 10's can increase the risk and severity of muscle problems.

How to manage the interaction:
Although there is a possible interaction between Lamivudine and Lefno-20 Tablet 10's, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms it's important to contact your doctor right away: fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine or bleeding. Do not stop using any medications without talking to your doctor.
LeflunomideTofacitinib
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Taking tofacitinib with Lefno-20 Tablet 10's can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between Lefno-20 Tablet 10's and tofacitinib together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideAmiodarone
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Coadministration of amiodarone with Lefno-20 Tablet 10's may raise the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Amiodarone and Lefno-20 Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomidePomalidomide
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Combining Pomalidomide with Lefno-20 Tablet 10's can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Lefno-20 Tablet 10's and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideCholine salicylate
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Taking Lefno-20 Tablet 10's with choline salicylate may increase the risk of developing liver disorder.

How to manage the interaction:
Although taking Lefno-20 Tablet 10's and choline salicylate together can result in an interaction, it can be taken together if prescribed by a doctor. However, if you experience any symptoms such as fever, joint pain or swelling, loss of appetite, vomiting, dark urine, pale stools, or yellowing of the skin or eyes, consult a doctor. Do not stop using any medications without consulting a doctor.
LeflunomideBelinostat
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Combining Belinostat with Lefno-20 Tablet 10's can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of Lefno-20 Tablet 10's with Belinostat can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any signs of liver damage, complications, infection, or any other symptoms like fever, chills, diarrhea, sore throat, muscle aches, or shortness of breath, contact your doctor right away. Other symptoms to watch out for include weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-coloured urine, or bleeding. Do not stop using any medications without talking to your doctor.
LeflunomidePhenytoin
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Coadministration of Phenytoin and Lefno-20 Tablet 10's may increase the risk of liver injury.

How to manage the interaction:
Although taking Phenytoin and Lefno-20 Tablet 10's together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideAlectinib
Severe
How does the drug interact with Lefno-20 Tablet 10's:
Taking alectinib with Lefno-20 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Lefno-20 Tablet 10's and alectinib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefno-20 Tablet Substitute

Substitutes safety advice
  • Lefra 20 Tablet 10's

    26.37per tablet
  • Rumalef 20 Tablet 30's

    17.90per tablet
  • Cleft 20 Tablet 10's

    21.83per tablet
  • Lefumide-20 Tablet 10's

    24.03per tablet
  • DM Lef 20 mg Tablet 10's

    24.48per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefno-20 Tablet . Alcohol intake, along with Lefno-20 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefno-20 Tablet while you are pregnant. Lefno-20 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefno-20 Tablet while you are breastfeeding. Lefno-20 Tablet passes into breast milk.

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Driving

Caution

Lefno-20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefno-20 Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefno-20 Tablet .

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Children

Unsafe

Lefno-20 Tablet is not approved for children under the age of 18 years.

FAQs

Lefno-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
Lefno-20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).
Lefno-20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefno-20 Tablet . Take Lefno-20 Tablet for as long as your doctor has prescribed to treat your condition effectually.
Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - LEF0005

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