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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefra 20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefra 20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lefra 20 Tablet

Lefra 20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefra 20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefra 20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefra 20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefra 20 Tablet if you are pregnant or planning for pregnancy, as Lefra 20 Tablet may cause serious congenital disabilities. Lefra 20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefra 20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefra 20 Tablet as it could lead to increased dizziness and liver damage. Lefra 20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefra 20 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefra 20 Tablet with or without food. Swallow Lefra 20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefra 20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefra 20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefra 20 Tablet Works

Lefra 20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefra 20 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefra 20 Tablet

Do not take more than the prescribed dose of Lefra 20 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefra 20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefra 20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefra 20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefra 20 Tablet may cause dizziness, so drive with caution. Lefra 20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideCarboplatin
Severe
LeflunomideRitonavir
Severe

Drug-Drug Interactions

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LeflunomideCarboplatin
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Co-administration of Lefra 20 Tablet 10's with carboplatin can increase the risk of infections.

How to manage the interaction:
Co-administration of carboplatin with Lefra 20 Tablet 10's can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideRitonavir
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Taking Lefra 20 Tablet 10's with Ritonavir affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Lefra 20 Tablet 10's and Ritonavir, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideTestosterone
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Co-administration of Lefra 20 Tablet 10's and Testosterone can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Lefra 20 Tablet 10's and testosterone, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideFlurbiprofen
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Using Flurbiprofen with Lefra 20 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Lefra 20 Tablet 10's, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
LeflunomideCarfilzomib
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Combining Carfilzomib with Lefra 20 Tablet 10's can increase the risk of negative side effects.

How to manage the interaction:
Taking Carfilzomib with Lefra 20 Tablet 10's together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include liver damage, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.
LeflunomideCisplatin
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Using Lefra 20 Tablet 10's together with CISplatin may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Lefra 20 Tablet 10's with Cisplatin can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhoea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideLevofloxacin
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Coadministration of Levofloxacin and Lefra 20 Tablet 10's can increase the risk of liver issues.

How to manage the interaction:
Although concomitant administration of levofloxacin alongside Lefra 20 Tablet 10's can result in an interaction, it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideTerbinafine
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Co-administration of Lefra 20 Tablet 10's and Terbinafine can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Lefra 20 Tablet 10's and terbinafine, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTriamcinolone
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Taking triamcinolone with Lefra 20 Tablet 10's can increase the risk of infection.

How to manage the interaction:
Although there is an interaction between Lefra 20 Tablet 10's and Triamcinolone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideAzacitidine
Severe
How does the drug interact with Lefra 20 Tablet 10's:
Taking azacitidine and Lefra 20 Tablet 10's together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between Lefra 20 Tablet 10's and azacitidine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefra 20 Tablet Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

    25.83per tablet
  • Rumalef 20 Tablet 30's

    19.68per tablet
  • Cleft 20 Tablet 10's

    21.83per tablet
  • Lefumide-20 Tablet 10's

    24.03per tablet
  • DM Lef 20 mg Tablet 10's

    24.48per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefra 20 Tablet . Alcohol intake, along with Lefra 20 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefra 20 Tablet while you are pregnant. Lefra 20 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefra 20 Tablet while you are breastfeeding. Lefra 20 Tablet passes into breast milk.

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Driving

Caution

Lefra 20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefra 20 Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefra 20 Tablet .

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Children

Unsafe

Lefra 20 Tablet is not approved for children under the age of 18 years.

FAQs

Lefra 20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
Lefra 20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).
Lefra 20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefra 20 Tablet . Take Lefra 20 Tablet for as long as your doctor has prescribed to treat your condition effectually.
Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - LEF0002

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