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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
DM Lef 20 mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, DM Lef 20 mg Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Overseas Health Care Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About DM Lef 20 mg Tablet

DM Lef 20 mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

DM Lef 20 mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take DM Lef 20 mg Tablet at the same time every day as prescribed by your doctor. In some cases, DM Lef 20 mg Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take DM Lef 20 mg Tablet if you are pregnant or planning for pregnancy, as DM Lef 20 mg Tablet may cause serious congenital disabilities. DM Lef 20 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. DM Lef 20 mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with DM Lef 20 mg Tablet as it could lead to increased dizziness and liver damage. DM Lef 20 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of DM Lef 20 mg Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take DM Lef 20 mg Tablet with or without food. Swallow DM Lef 20 mg Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

DM Lef 20 mg Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. DM Lef 20 mg Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How DM Lef 20 mg Tablet Works

DM Lef 20 mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of DM Lef 20 mg Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of DM Lef 20 mg Tablet

Do not take more than the prescribed dose of DM Lef 20 mg Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take DM Lef 20 mg Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. DM Lef 20 mg Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking DM Lef 20 mg Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. DM Lef 20 mg Tablet may cause dizziness, so drive with caution. DM Lef 20 mg Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideAtorvastatin
Severe
LeflunomideMercaptopurine
Severe

Drug-Drug Interactions

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LeflunomideAtorvastatin
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
When atorvastatin and DM Lef 20 mg Tablet 10's are taken together it can increase the risk of liver problems.

How to manage the interaction:
Although taking Atorvastatin and DM Lef 20 mg Tablet 10's together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideMercaptopurine
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Co-administration of Mercaptopurine with DM Lef 20 mg Tablet 10's can increase the risk of infections and liver problems.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet 10's and mercaptopurine, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideDuloxetine
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Coadministration of duloxetine and DM Lef 20 mg Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Although taking Duloxetine with Cyclobenzaprine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, itching, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LeflunomideLevofloxacin
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Coadministration of Levofloxacin and DM Lef 20 mg Tablet 10's can increase the risk of liver issues.

How to manage the interaction:
Although concomitant administration of levofloxacin alongside DM Lef 20 mg Tablet 10's can result in an interaction, it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideDexamethasone
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Taking Dexamethasone with DM Lef 20 mg Tablet 10's may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with DM Lef 20 mg Tablet 10's if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
LeflunomideDeferasirox
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
DM Lef 20 mg Tablet 10's may cause liver problems and using it with deferasirox may increase that risk.

How to manage the interaction:
Taking DM Lef 20 mg Tablet 10's with Deferasirox together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or any other unusual signs, make sure to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideBrodalumab
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Combining Brodalumab with DM Lef 20 mg Tablet 10's can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of DM Lef 20 mg Tablet 10's with Brodalumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice symptoms like fever, chills, diarrhea, shortness of breath, weight loss, pain or burning while urinating, sore throat, or muscle aches, it's best to contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeflunomideBupropion
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
DM Lef 20 mg Tablet 10's can cause liver issues, and combining it with bupropion, can enhance the risk.

How to manage the interaction:
Co-administration of bupropion along with DM Lef 20 mg Tablet 10's can lead to interaction, it can be taken if recommended by a doctor. If you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideNaproxen
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Coadministration of Naproxen and DM Lef 20 mg Tablet 10's can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Naproxen and DM Lef 20 mg Tablet 10's together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomidePosaconazole
Severe
How does the drug interact with DM Lef 20 mg Tablet 10's:
Taking DM Lef 20 mg Tablet 10's with posaconazole can increase the risk of liver problems.

How to manage the interaction:
Although using Posaconazole and DM Lef 20 mg Tablet 10's together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

DM Lef 20 mg Tablet Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

    25.83per tablet
  • Lefra 20 Tablet 10's

    26.37per tablet
  • Rumalef 20 Tablet 30's

    19.68per tablet
  • Cleft 20 Tablet 10's

    21.83per tablet
  • Lefumide-20 Tablet 10's

    24.03per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking DM Lef 20 mg Tablet . Alcohol intake, along with DM Lef 20 mg Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are pregnant. DM Lef 20 mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are breastfeeding. DM Lef 20 mg Tablet passes into breast milk.

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Driving

Caution

DM Lef 20 mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking DM Lef 20 mg Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking DM Lef 20 mg Tablet .

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Children

Unsafe

DM Lef 20 mg Tablet is not approved for children under the age of 18 years.

FAQs

DM Lef 20 mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
DM Lef 20 mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).
DM Lef 20 mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of DM Lef 20 mg Tablet . Take DM Lef 20 mg Tablet for as long as your doctor has prescribed to treat your condition effectually.
Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

335 KM. MILESTONE, NATIONAL HIGHWAY NO.1, P.O.BOX 25, PHILLAUR , (PUNJAB) INDIA-144 410
Other Info - DML0002

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