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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Carbozar 450 mg Injection 45 ml is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Carbozar 450 mg Injection 45 ml

Carbozar 450 mg Injection 45 ml belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Carbozar 450 mg Injection 45 ml contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Carbozar 450 mg Injection 45 ml is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of Carbozar 450 mg Injection 45 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Carbozar 450 mg Injection 45 ml for as long as your doctor has prescribed. Do not stop the Carbozar 450 mg Injection 45 ml midway. Talk to your doctor before taking Carbozar 450 mg Injection 45 ml if you have severe allergic reactions to Carbozar 450 mg Injection 45 ml or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbozar 450 mg Injection 45 ml should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbozar 450 mg Injection 45 ml if you are pregnant or breastfeeding because this Carbozar 450 mg Injection 45 ml can cause harmful effects on the unborn baby. Both women and men using this Carbozar 450 mg Injection 45 ml should use birth control to avoid pregnancy.

Uses of Carbozar 450 mg Injection 45 ml

Treatment of Ovarian cancer and Small cell lung cancer

Directions for Use

Parenteral: Carbozar 450 mg Injection 45 ml will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Carbozar 450 mg Injection 45 ml contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

How Carbozar 450 mg Injection 45 ml Works

Carbozar 450 mg Injection 45 ml contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Carbozar 450 mg Injection 45 ml

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Hair loss and numbness
  • Tingling
  • Burning
  • Pain in the hands or feet
  • Nephrotoxicity at high doses
  • Electrolyte disturbances
  • Thrombocytopenia (low blood platelet count)
  • Peripheral neuropathy (nerves malfunction)
  • Leukopenia (low white blood cell count)

What if I have taken an overdose of Carbozar 450 mg Injection 45 ml

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as black/tarry/bloody stools, bloody vomit or vomited material that looks like coffee grounds, unusual bruising or bleeding, decreased urination, pain, burning, or tingling in the hands or feet, ringing in ears and difficulty hearing.

Drug Warnings

Carbozar 450 mg Injection 45 ml should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Carbozar 450 mg Injection 45 ml. To treat your condition effectually, continue taking Carbozar 450 mg Injection 45 ml for as long as your doctor has prescribed. Do not stop the Carbozar 450 mg Injection 45 ml midway. Talk to your doctor before taking Carbozar 450 mg Injection 45 ml if you have severe allergic reactions to Carbozar 450 mg Injection 45 ml or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbozar 450 mg Injection 45 ml should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbozar 450 mg Injection 45 ml if you are pregnant or breastfeeding because this Carbozar 450 mg Injection 45 ml can cause harmful effects on the unborn baby. Both women and men using this Carbozar 450 mg Injection 45 ml should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Carbozar 450 mg Injection 45 ml treatment and appropriate until recovery is achieved.

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
CarboplatinAdalimumab
Severe

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Co-administration of Sorafenib with CARBOZAR 450MG/45ML INJ can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with CARBOZAR 450MG/45ML INJ together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinAdalimumab
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Using Adalimumab with CARBOZAR 450MG/45ML INJ can increase the risk of developing serious infections.

How to manage the interaction:
Although taking CARBOZAR 450MG/45ML INJ and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinBacitracin
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Taking CARBOZAR 450MG/45ML INJ and bacitracin can increase the risk of nephrotoxicity(kidney damage).

How to manage the interaction:
Co-administration of CARBOZAR 450MG/45ML INJ and bacitracin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult the doctor. Do not discontinue any medications without a doctor's advice.
CarboplatinClozapine
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Taking CARBOZAR 450MG/45ML INJ with Clozapine may enhance the risk of serious infection.

How to manage the interaction:
Co-administration of CARBOZAR 450MG/45ML INJ with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinLeflunomide
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Co-administration of leflunomide with CARBOZAR 450MG/45ML INJ can increase the risk of infections.

How to manage the interaction:
Co-administration of CARBOZAR 450MG/45ML INJ with leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
CarboplatinCladribine
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Using cladribine and CARBOZAR 450MG/45ML INJ together can increase the risk of serious infections.

How to manage the interaction:
Co-administration of CARBOZAR 450MG/45ML INJ and cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinTofacitinib
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Co-administration of CARBOZAR 450MG/45ML INJ with tofacitinib can increase the risk of serous infections.

How to manage the interaction:
Although there is an interaction, CARBOZAR 450MG/45ML INJ can be taken with tofacitinib if prescribed by the doctor. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, breathing difficulty, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
CarboplatinFingolimod
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Using CARBOZAR 450MG/45ML INJ with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between CARBOZAR 450MG/45ML INJ and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinThalidomide
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Taking CARBOZAR 450MG/45ML INJ with thalidomide can increase the risk of blood clots.

How to manage the interaction:
Co-administration of CARBOZAR 450MG/45ML INJ with thalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience chest pain, breathing difficulty, coughing up blood, and pain, redness, or swelling in an arm or leg, sudden loss of vision, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarboplatinCertolizumab
Severe
How does the drug interact with CARBOZAR 450MG/45ML INJ:
Using CARBOZAR 450MG/45ML INJ with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking CARBOZAR 450MG/45ML INJ with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Carbozar 450 mg Injection 45 ml Substitute

Substitutes safety advice
  • Kemocarb 450 mg Injection 45 ml

    54.24per tablet
  • CARBOPLATIN 450MG INJECTION 45ML

    58.21per tablet
  • Carbopa 450 Injection 45 ml

    54.24per tablet
  • CARBOKEM NOVA 450MG INJECTION

    2177.10per tablet
  • UNICARB 450MG INJECTION

    53.10per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Carbozar 450 mg Injection 45 ml. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Carbozar 450 mg Injection 45 ml should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Carbozar 450 mg Injection 45 ml and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Carbozar 450 mg Injection 45 ml should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Carbozar 450 mg Injection 45 ml may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Carbozar 450 mg Injection 45 ml may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Carbozar 450 mg Injection 45 ml. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Carbozar 450 mg Injection 45 ml. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

FAQs

Carbozar 450 mg Injection 45 ml is used to treat ovarian cancer and small-cell lung cancer.
Carbozar 450 mg Injection 45 ml contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
Yes, Carbozar 450 mg Injection 45 ml can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Carbozar 450 mg Injection 45 ml should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Before you receive treatment with Carbozar 450 mg Injection 45 ml, tell your doctor about all of your medical conditions. You should not receive Carbozar 450 mg Injection 45 ml if you are allergic to carboplatin or any contents in Carbozar 450 mg Injection 45 ml. It should not be employed in patients with severe bone marrow depression or significant bleeding.
If not given an inappropriate dose, Carbozar 450 mg Injection 45 ml can cause toxic effects, although not everyone gets it. So, Carbozar 450 mg Injection 45 ml is prescribed by a doctor experienced in the use of medications to treat cancer only.
Avoid taking Carbozar 450 mg Injection 45 ml if you are pregnant because Carbozar 450 mg Injection 45 ml can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Carbozar 450 mg Injection 45 ml.
Carbozar 450 mg Injection 45 ml is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Carbozar 450 mg Injection 45 ml is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.
Yes, Carbozar 450 mg Injection 45 ml is FDA approved. It was approved on 3 March 1989.
Yes, Carbozar 450 mg Injection 45 ml is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.
Carbozar 450 mg Injection 45 ml may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Carbozar 450 mg Injection 45 ml, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.
Carbozar 450 mg Injection 45 ml is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.
Yes, sometimes the doctor may suggest Carbozar 450 mg Injection 45 ml to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.
Carbozar 450 mg Injection 45 ml is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.
The common side effects of the Carbozar 450 mg Injection 45 ml are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
The efficacy and safety of Carbozar 450 mg Injection 45 ml have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.

Country of origin

India

Manufacturer/Marketer address

463, 4 Th Floor, Rpg House, Dr. Annie Besant Road, Worli, Mumbai 400 030. Maharashtra, India
Other Info - CAR1480

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