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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Carbopa 450 Injection is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Carbopa 450 Injection

Carbopa 450 Injection belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Carbopa 450 Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Carbopa 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of Carbopa 450 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Carbopa 450 Injection for as long as your doctor has prescribed. Do not stop the Carbopa 450 Injection midway. Talk to your doctor before taking Carbopa 450 Injection if you have severe allergic reactions to Carbopa 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbopa 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbopa 450 Injection if you are pregnant or breastfeeding because this Carbopa 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Carbopa 450 Injection should use birth control to avoid pregnancy.

Uses of Carbopa 450 Injection

Treatment of Ovarian cancer and Small cell lung cancer

Directions for Use

Parenteral: Carbopa 450 Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Carbopa 450 Injection contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

How Carbopa 450 Injection Works

Carbopa 450 Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Carbopa 450 Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Hair loss and numbness
  • Tingling
  • Burning
  • Pain in the hands or feet
  • Nephrotoxicity at high doses
  • Electrolyte disturbances
  • Thrombocytopenia (low blood platelet count)
  • Peripheral neuropathy (nerves malfunction)
  • Leukopenia (low white blood cell count)

What if I have taken an overdose of Carbopa 450 Injection

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as black/tarry/bloody stools, bloody vomit or vomited material that looks like coffee grounds, unusual bruising or bleeding, decreased urination, pain, burning, or tingling in the hands or feet, ringing in ears and difficulty hearing.

Drug Warnings

Carbopa 450 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Carbopa 450 Injection. To treat your condition effectually, continue taking Carbopa 450 Injection for as long as your doctor has prescribed. Do not stop the Carbopa 450 Injection midway. Talk to your doctor before taking Carbopa 450 Injection if you have severe allergic reactions to Carbopa 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbopa 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbopa 450 Injection if you are pregnant or breastfeeding because this Carbopa 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Carbopa 450 Injection should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Carbopa 450 Injection treatment and appropriate until recovery is achieved.

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
CarboplatinThalidomide
Severe

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
How does the drug interact with Carbopa 450 Injection 45 ml:
Co-administration of Sorafenib with Carbopa 450 Injection 45 ml can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Carbopa 450 Injection 45 ml together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinThalidomide
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Taking Carbopa 450 Injection 45 ml with thalidomide can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Carbopa 450 Injection 45 ml with thalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience chest pain, breathing difficulty, coughing up blood, and pain, redness, or swelling in an arm or leg, sudden loss of vision, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarboplatinBacitracin
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Taking Carbopa 450 Injection 45 ml and bacitracin can increase the risk of nephrotoxicity(kidney damage).

How to manage the interaction:
Co-administration of Carbopa 450 Injection 45 ml and bacitracin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult the doctor. Do not discontinue any medications without a doctor's advice.
CarboplatinBaricitinib
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Coadministration of baricitinib and Carbopa 450 Injection 45 ml can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Carbopa 450 Injection 45 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
CarboplatinClozapine
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Taking Carbopa 450 Injection 45 ml with Clozapine may enhance the risk of serious infection.

How to manage the interaction:
Co-administration of Carbopa 450 Injection 45 ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinEtanercept
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Taking Carbopa 450 Injection 45 ml with etanercept may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Carbopa 450 Injection 45 ml and etanercept can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm (mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinCladribine
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Using cladribine and Carbopa 450 Injection 45 ml together can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Carbopa 450 Injection 45 ml and cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinCertolizumab
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Using Carbopa 450 Injection 45 ml with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking Carbopa 450 Injection 45 ml with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinFingolimod
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Using Carbopa 450 Injection 45 ml with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Carbopa 450 Injection 45 ml and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinTofacitinib
Severe
How does the drug interact with Carbopa 450 Injection 45 ml:
Co-administration of Carbopa 450 Injection 45 ml with tofacitinib can increase the risk of serous infections.

How to manage the interaction:
Although there is an interaction, Carbopa 450 Injection 45 ml can be taken with tofacitinib if prescribed by the doctor. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, breathing difficulty, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Carbopa 450 Injection Substitute

Substitutes safety advice
  • Kemocarb 450 mg Injection 45 ml

    54.24per tablet
  • CARBOPLATIN 450MG INJECTION 45ML

    58.21per tablet
  • CARBOKEM NOVA 450MG INJECTION

    2177.10per tablet
  • UNICARB 450MG INJECTION

    53.10per tablet
  • Biocarb 450 mg Injection 45 ml

    59.53per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Carbopa 450 Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Carbopa 450 Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Carbopa 450 Injection and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Carbopa 450 Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Carbopa 450 Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Carbopa 450 Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Carbopa 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Carbopa 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

FAQs

Carbopa 450 Injection is used to treat ovarian cancer and small-cell lung cancer.
Carbopa 450 Injection contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
Yes, Carbopa 450 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Carbopa 450 Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Before you receive treatment with Carbopa 450 Injection, tell your doctor about all of your medical conditions. You should not receive Carbopa 450 Injection if you are allergic to carboplatin or any contents in Carbopa 450 Injection. It should not be employed in patients with severe bone marrow depression or significant bleeding.
If not given an inappropriate dose, Carbopa 450 Injection can cause toxic effects, although not everyone gets it. So, Carbopa 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer only.
Avoid taking Carbopa 450 Injection if you are pregnant because Carbopa 450 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Carbopa 450 Injection.
Carbopa 450 Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Carbopa 450 Injection is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.
Yes, Carbopa 450 Injection is FDA approved. It was approved on 3 March 1989.
Yes, Carbopa 450 Injection is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.
Carbopa 450 Injection may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Carbopa 450 Injection, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.
Carbopa 450 Injection is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.
Yes, sometimes the doctor may suggest Carbopa 450 Injection to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.
Carbopa 450 Injection is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.
The common side effects of the Carbopa 450 Injection are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
The efficacy and safety of Carbopa 450 Injection have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - CAR0303

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