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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:46 PM IST
Carbowel 450 mg Injection is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer

Getwell Oncology Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Carbowel 450 mg Injection

Carbowel 450 mg Injection belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Carbowel 450 mg Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Carbowel 450 mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of Carbowel 450 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Carbowel 450 mg Injection for as long as your doctor has prescribed. Do not stop the Carbowel 450 mg Injection midway. Talk to your doctor before taking Carbowel 450 mg Injection if you have severe allergic reactions to Carbowel 450 mg Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbowel 450 mg Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbowel 450 mg Injection if you are pregnant or breastfeeding because this Carbowel 450 mg Injection can cause harmful effects on the unborn baby. Both women and men using this Carbowel 450 mg Injection should use birth control to avoid pregnancy.

Uses of Carbowel 450 mg Injection

Treatment of Ovarian cancer and Small cell lung cancer

Medicinal Benefits

Carbowel 450 mg Injection contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

Directions for Use

Parenteral: Carbowel 450 mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Carbowel 450 mg Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Hair loss and numbness
  • Tingling
  • Burning
  • Pain in the hands or feet
  • Nephrotoxicity at high doses
  • Electrolyte disturbances
  • Thrombocytopenia (low blood platelet count)
  • Peripheral neuropathy (nerves malfunction)
  • Leukopenia (low white blood cell count)

Drug Warnings

Carbowel 450 mg Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Carbowel 450 mg Injection. To treat your condition effectually, continue taking Carbowel 450 mg Injection for as long as your doctor has prescribed. Do not stop the Carbowel 450 mg Injection midway. Talk to your doctor before taking Carbowel 450 mg Injection if you have severe allergic reactions to Carbowel 450 mg Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbowel 450 mg Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbowel 450 mg Injection if you are pregnant or breastfeeding because this Carbowel 450 mg Injection can cause harmful effects on the unborn baby. Both women and men using this Carbowel 450 mg Injection should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Carbowel 450 mg Injection treatment and appropriate until recovery is achieved.

Drug Interactions

Drug-Drug Interactions: Carbowel 450 mg Injection interacts with medicines used in the treatment of chemotherapy (e.g. pemetrexed, gemcitabine, pegfilgrastim, paclitaxel, docetaxel), antacid medications (e.g. pantoprazole) and antibiotic medications (e.g. amikacin, gentamicin, kanamycin, streptomycin, tobramycin).

Drug-Food Interactions: No food interaction was found.

Drug-Disease Interactions: Inform your doctor before taking Carbowel 450 mg Injection it requires close monitoring if you are suffering from Infection (bacterial/fungal/protozoal/viral), bleeding disorders, bone marrow depression/low blood counts, fever, renal dysfunction or disorders, peripheral neuropathy (nerves malfunction).

Drug-Drug Interactions Checker List

  • PEMETREXED
  • GEMCITABINE
  • PEGFILGRASTIM
  • PACLITAXEL
  • PANTOPRAZOLE
  • AMIKACIN
  • GENTAMICIN
  • KANAMYCIN
  • STREPTOMYCIN
  • TOBRAMYCIN
  • DOCETAXEL

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Special Advise

  • Peripheral blood counts should be frequently monitored during carboplatin treatment and, when appropriate, until recovery is achieved.
  • Carbowel 450 mg Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Carbowel 450 mg Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Carbowel 450 mg Injection may make your skin sensitive to sunlight.

Disease/Condition Glossary

Ovarian cancer: Cancer that forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Carbowel 450 mg Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Carbowel 450 mg Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Carbowel 450 mg Injection and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Carbowel 450 mg Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Carbowel 450 mg Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Carbowel 450 mg Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Carbowel 450 mg Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Carbowel 450 mg Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

Country of origin

India

Manufacturer/Marketer address

464, Udyog Vihar, Phase-V Sector 19, Gurugram Haryana 122016
Other Info - CAR0627

Author Details

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FAQs

Carbowel 450 mg Injection is used to treat ovarian cancer and small-cell lung cancer.
Carbowel 450 mg Injection contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
Yes, Carbowel 450 mg Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Carbowel 450 mg Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Before you receive treatment with Carbowel 450 mg Injection, tell your doctor about all of your medical conditions. You should not receive Carbowel 450 mg Injection if you are allergic to carboplatin or any contents in Carbowel 450 mg Injection. It should not be employed in patients with severe bone marrow depression or significant bleeding.
If not given an inappropriate dose, Carbowel 450 mg Injection can cause toxic effects, although not everyone gets it. So, Carbowel 450 mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer only.
Avoid taking Carbowel 450 mg Injection if you are pregnant because Carbowel 450 mg Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Carbowel 450 mg Injection.
Carbowel 450 mg Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Carbowel 450 mg Injection is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.
Yes, Carbowel 450 mg Injection is FDA approved. It was approved on 3 March 1989.
Yes, Carbowel 450 mg Injection is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.
Carbowel 450 mg Injection may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Carbowel 450 mg Injection, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.
Carbowel 450 mg Injection is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.
Yes, sometimes the doctor may suggest Carbowel 450 mg Injection to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.
Carbowel 450 mg Injection is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.
The common side effects of the Carbowel 450 mg Injection are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
The efficacy and safety of Carbowel 450 mg Injection have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.

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