DESIDUSTAT
About
DESIDUSTAT is a novel medication primarily used for treating anaemia associated with chronic kidney disease (CKD) in patients receiving dialysis or not. Anaemia is a condition that arises when your blood produces fewer healthy red blood cells than usual.
DESIDUSTAT contains Desidustat. It works by preventing the enzymatic degradation of HIF-1α by inhibiting the PHD enzymes. In consequence, the hematocrit rises, and haemoglobin concentrations increase.
DESIDUSTAT should be taken as prescribed by your doctor. In some cases, DESIDUSTAT may cause certain side effects, including fever, vomiting, abnormal weakness, and peripheral oedema (swelling of your lower legs or hands). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Before taking the DESIDUSTAT, let your doctor know about all your medical conditions, sensitivities, and all medications you are using, including supplements and herbs. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Uses of DESIDUSTAT
Medicinal Benefits
DESIDUSTAT contains Desidustat, which is used to treat anaemia associated with chronic kidney disease (CKD) in patients either on dialysis or not on dialysis. Desidustat works by preventing the enzymatic degradation of HIF-1α by inhibiting the PHD enzymes. In consequence, the hematocrit rises, and haemoglobin concentrations increase.
Directions for Use
Storage
Side Effects of DESIDUSTAT
- Fever
- Vomiting
- Abnormal physical weakness
- Peripheral oedema (swelling of your lower legs or hands)
In-Depth Precautions and Warning
Drug Warnings
It is recommended not to use it if you are allergic to any component present in it. The safety of DESIDUSTAT in pregnant women and nursing mothers is unknown. Therefore, it is not recommended to use it unless instructed by the doctor. So, inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
Drug Interactions
Drug-Drug Interactions: No major interactions were reported.
Drug-Food Interactions: Limit or quit the consumption of alcohol.
Drug-Disease Interactions: No major interactions were reported.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consumption of alcohol with DESIDUSTAT as it may cause serious side effects.
Pregnancy
cautionThere is no information available about the use of DESIDUSTAT during pregnancy. Inform your doctor if you are pregnant or suspect you are pregnant. Before prescribing DESIDUSTAT, your doctor will assess the benefits and potential hazards.
Breast Feeding
cautionThere is no information available about the use of DESIDUSTAT during breastfeeding. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing DESIDUSTAT.
Driving
cautionIt is not known whether DESIDUSTAT alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Liver
cautionThere is no information available about the use of DESIDUSTAT in patients with liver impairment. Inform your doctor if you have liver problems. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
safe if prescribedDESIDUSTAT is prescribed for the treatment of anemia induced by chronic kidney disease. Your doctor will decide the dose of this medicine based on your disease condition.
Children
cautionThe safety and efficacy of DESIDUSTAT in children was not established.
Habit Forming
Diet & Lifestyle Advise
- Follow a well-balanced diet. And do regular physical exercise.
- It is best if taken along with a low-protein diet as it helps delay the progression of kidney diseases.
- People with kidney problems are advised to limit sodium in their diet, including added salt.
- Olive oil is a healthy source of fat and phosphorus-free, making it a great option for people with kidney disease.
- Bulgur is a whole-grain wheat product that makes a terrific, kidney-friendly alternative to other whole grains high in phosphorus and potassium.
- Blueberries are packed with nutrients and are one of the best sources of antioxidants you can eat.
- Include dark-green leafy vegetables, cereals, bread, meat, pulses (beans, peas and lentils), and dried fruit like apricots, prunes and raisins in your diet.
- Increase your intake of fruits in your diet, especially fruits rich in iron, like pomegranate and citrus fruits.
- Limit the consumption of tea, coffee, milk, dairy, and foods with high levels of phytic acids, such as whole-grain cereals.
- Limit junk food items from outside and stick to freshly prepared home-cooked meals.
Special Advise
- You'll also be advised to have regular check-ups to monitor your condition.
- People with CKD may need to closely monitor sodium and phosphorus in foods, especially if their kidney disease is advanced.
Patients Concern
Disease/Condition Glossary
Anaemia: Anaemia is caused by a lack of iron in the body. Iron is an essential mineral for overall health and healthy blood cells. Iron aids in the production of haemoglobin, which is present in red blood cells. When there is a lack of iron, red blood cells do not produce enough haemoglobin to transport oxygen. Anaemia is a typical consequence of chronic renal disease (CKD). CKD indicates that your kidneys are damaged and are unable to filter blood as effectively as they should. CKD can also lead to other health issues.
FAQs
DESIDUSTAT is used to treat anaemia associated with chronic kidney disease (CKD).
DESIDUSTAT contains Desidustat. It works by preventing the enzymatic degradation of HIF-1α by inhibiting the PHD enzymes. In consequence, the hematocrit rises, and haemoglobin concentrations increase.
People who do not acquire enough iron, vitamin B12, and folic acid to create healthy red blood cells are more likely to develop anaemia. Excessive alcohol use increases your risk of anaemia.
Eating foods like red meat, beans, and peas can be beneficial if one has vitamin deficiency anaemia. In addition, items like dry fruits, dark green leafy vegetables, and seafood can supply the necessary vitamins and minerals.
Yes, DESIDUSTAT may cause Peripheral oedema (swelling of your lower legs or hands). If symptoms persist or bother you, reach out to the doctor immediately.
The side effects of DESIDUSTAT include vomiting, fever, abnormal physical weakness and peripheral oedema (swelling of your lower legs or hands). If these side effects persist or worsen, please consult your doctor.
Chronic kidney disease or CKD is irreversible and progressive loss of kidney function. As a result, the body retains excess waste or toxins and may lead to other health problems. The symptoms include swelling of legs, shortness of breath, swelling around the eyes, weight loss, fatigue (overtiredness), decreased urine output, nausea or vomiting especially in the morning or after eating, loss of appetite and trouble sleeping.
Your doctor may recommend a blood test to determine whether you have kidney disease. The test measures the amount of creatinine (waste product) in your blood. The doctor will use the blood test results, your gender, age, weight, and ethnic group to calculate how many milliliters of waste your kidneys should be able to filter in a minute. This calculation is known as your eGFR or estimated glomerular filtration rate. Healthy kidneys should be able to filter more than 90 mL/min. If your rate is lower than this, you may have kidney disease.
If you have diabetes, high blood pressure, heart disease, or a family history of kidney failure, you are more likely to develop kidney disease. If you have risk factors, it is advisable to get examined for kidney disease and protect your kidneys by changing your diet, lifestyle and controlling your blood glucose levels and blood pressure.
Your kidneys make erythropoietin (EPO), an important hormone that instructs your body to produce red blood cells. Kidneys fail to make enough EPO in case of kidney disease. Low EPO levels decreases red blood cell count resulting in anemia.
The risk for anemia increases when kidney disease worsens. People with CKD who also have diabetes are at a greater risk for developing anemia, likely to develop anemia earlier, and often have more severe anemia than those without diabetes. In addition, anemia with CKD is more common in people aged over 60 years.
Some of the symptoms of anemia in patients with CKD include dizziness, pale skin, fatigue (overtiredness), headache, shortness of breath, body pain, and irregular or fast heartbeats.
In patients with CKD, severe anemia can increase the risk of heart problems and strokes due to low oxygen levels in the body, which results from the decreasing level of red blood cells in the body.
