Tizidal D 50mg/2mg Tablet is a combination medicine that contains pain relievers and muscle relaxants. It is used to treat spasticity (muscle stiffness and spasms) associated with pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. A muscle spasm occurs due to involuntary contractions of a muscle. A spasm may be a muscle cramp or feel tight or stiff, like a knot.

Tizidal D 50mg/2mg Tablet contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac blocks prostaglandins (PGs) that cause pain and swelling. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. As a result, Tizidal D 50mg/2mg Tablet helps to reduce muscle stiffness, spasms, and pain.

Tizidal D 50mg/2mg Tablet is prescribed medication, and it should be taken as directed by the doctor. In some cases, you may experience common side effects such as feeling or being sick (vomiting), diarrhoea, headaches, drowsiness and ringing in your ears (tinnitus), fluctuations in blood pressure, dry mouth, stomach upsets, and decrease or increase in heart rate. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before prescribing Tizidal D 50mg/2mg Tablet, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Also, tell your doctor about your medical history and other medications you are currently taking to rule out any potential adverse effects. Do not take Tizidal D 50mg/2mg Tablet unless recommended by the doctor if you are pregnant or planning pregnancy or breastfeeding. Tizidal D 50mg/2mg Tablet may cause dizziness, so drive only if you are alert and focused. Tizidal D 50mg/2mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol while on treatment with Tizidal D 50mg/2mg Tablet as it could lead to liver damage.

Tizidal D 50mg/2mg Tablet contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac inhibits the production of prostaglandins (PGs), which induce pain and swelling. Tizanidine modulates the spinal cord and brain centres. This aids in the relief of muscle stiffness and the improvement of muscle movements. As a result, Tizidal D 50mg/2mg Tablet aids in relieving muscle stiffness, spasms, and pain.

• Vomiting
• Diarrhoea
• Headaches
• Drowsiness
• Ringing in your ears (tinnitus)
• Fluctuations in blood pressure
• Dry mouth
• Stomach upsets
• Decrease or increase in heart rate

Do not take Tizidal D 50mg/2mg Tablet if you are allergic to its components. Inform your doctor about all your medical conditions, especially if you have/ had hepatotoxicity, hypotension, renal dysfunction or renal toxicities, asthma, fluid retention, GI toxicity, rash, or thrombosis (blood clots). It is not recommended to take Tizidal D 50mg/2mg Tablet during pregnancy or whilst breastfeeding. Tizidal D 50mg/2mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Tizidal D 50mg/2mg Tablet is not recommended for children as safety and effectiveness have not been established. Do not stop taking Tizidal D 50mg/2mg Tablet unless your doctor tells you to. Treatment with Tizidal D 50mg/2mg Tablet should be stopped gradually. Stopping treatment suddenly may cause effects such as an increase in heart rate and high blood pressure.

Drug-Drug Interactions: Tizidal D 50mg/2mg Tablet may interact with certain pain killers (e.g. hydrocodone), anti-depressants (e.g. fluvoxamine, escitalopram), antibiotics (e.g. ciprofloxacin), antihypertensives (e.g. metoprolol), anticoagulant (e.g. apixaban), certain painkillers (e.g. celecoxib), and antiretroviral medicine (e.g. tenofovir).

Drug-Food Interactions: Do not drink alcohol while taking Tizidal D 50mg/2mg Tablet.

Drug-Disease Interactions: Tizidal D 50mg/2mg Tablet may interact with various disease conditions that include ulcer or perforation, bleeding problems, hepatotoxicity (liver impairment), hypotension, renal dysfunction or toxicities, asthma, fluid retention, GI toxicity, rash, thrombosis (blood clots).

• HYDROCODONE
• FLUVOXAMINE
• ESCITALOPRAM
• METOPROLOL
• APIXABAN
• CELECOXIB
• TENOFOVIR

• Regular exercise helps muscle stretch, making them less likely to spasm, tear, and sprain. Mild activities such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Rest well, and get plenty of sleep.
• Change your position at least every two hours to avoid developing pressure sores.
• Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.
• Stay hydrated, drink plenty of water.

Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. A spasm may be a twitch in the muscle or feel tight or hard, like a knot.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific body area). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.