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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tasibenz-150 Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (a type of blood cancer). It contains Nilotinib, which works by blocking the action of an abnormal protein produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thus, it stops the multiplication, inhibits the growth of cancerous cells, and then causes their death.

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Composition :

NILOTINIB-150MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

ORAL

Return Policy :

Not Returnable

About Tasibenz-150 Capsule 28's

Tasibenz-150 Capsule 28's belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.

Tasibenz-150 Capsule 28's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Take Tasibenz-150 Capsule 28's as prescribed. You are recommended to take Tasibenz-150 Capsule 28's for as long as your doctor has advised it for you based on your medical condition. Sometimes, Tasibenz-150 Capsule 28's may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Tasibenz-150 Capsule 28's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Tasibenz-150 Capsule 28's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Tasibenz-150 Capsule 28's and for two weeks after completing the course of Tasibenz-150 Capsule 28's. Tasibenz-150 Capsule 28's is not recommended for children below one year of age. Drive only if you are alert as Tasibenz-150 Capsule 28's may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Tasibenz-150 Capsule 28's, contact your doctor immediately, as these might be symptoms of liver problems. 

Uses of Tasibenz-150 Capsule 28's

Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)

Directions for Use

Take this medicine on an empty stomach or as advised by the doctor. Avoid eating food for at least 2 hours before taking Tasibenz-150 Capsule 28's and avoid eating for at least 1 hour after taking Tasibenz-150 Capsule 28's. Swallow it as a whole with a glass of water. If you are unable to swallow it, open the capsule and sprinkle the contents in 1 teaspoon of applesauce and take it right away (within 15 minutes). Do not use more than one teaspoon of apple sauce for each capsule, and do not use any food other than apple sauce.

Medicinal Benefits

Tasibenz-150 Capsule 28's contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Tasibenz-150 Capsule 28's is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib. 

How Tasibenz-150 Capsule 28's Works

Tasibenz-150 Capsule 28's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tasibenz-150 Capsule 28's

  • Vomiting
  • Nausea
  • Diarrhoea
  • Headache
  • Constipation
  • Tiredness
  • Muscle and joint pain

What if I have taken an overdose of Tasibenz-150 Capsule 28's

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Tasibenz-150 Capsule 28's may include drowsiness and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Tasibenz-150 Capsule 28's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Tasibenz-150 Capsule 28's and for two weeks after completing the course of Tasibenz-150 Capsule 28's. Tasibenz-150 Capsule 28's is not recommended for children below one year of age. Tasibenz-150 Capsule 28's may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Tasibenz-150 Capsule 28's. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Tasibenz-150 Capsule 28's may cause dizziness or visual disorders as side effects in some people. Tasibenz-150 Capsule 28's may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Tasibenz-150 Capsule 28's, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Tasibenz-150 Capsule 28's may contain lactose. Most people who have mild or moderate lactose intolerance can take Tasibenz-150 Capsule 28's. Avoid taking Tasibenz-150 Capsule 28's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Tasibenz-150 Capsule 28's.

Drug-Drug Interactions

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NilotinibZiprasidone
Critical
NilotinibMesoridazine
Critical

Drug-Drug Interactions

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NilotinibZiprasidone
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Taking Tasibenz-150 Capsule 28's with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Tasibenz-150 Capsule 28's with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
NilotinibMesoridazine
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Combining Mesoridazine and Tasibenz-150 Capsule 28's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine and Tasibenz-150 Capsule 28's together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibSaquinavir
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Combining Saquinavir and Tasibenz-150 Capsule 28's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Saquinavir and Tasibenz-150 Capsule 28's together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibCisapride
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Combining Cisapride and Tasibenz-150 Capsule 28's can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Cisapride and Tasibenz-150 Capsule 28's together is generally avoided as it can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
NilotinibGrepafloxacin
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Coadministration of Grepafloxacin with Tasibenz-150 Capsule 28's can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Tasibenz-150 Capsule 28's with Grepafloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibBCG vaccine
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Combining BCG vaccine with Tasibenz-150 Capsule 28's can increase the risk of infection.

How to manage the interaction:
Taking Tasibenz-150 Capsule 28's with BCG vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibLeuprorelin
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Using Tasibenz-150 Capsule 28's together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuprorelin with Tasibenz-150 Capsule 28's is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibSparfloxacin
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Coadministration of Sparfloxacin with Tasibenz-150 Capsule 28's can prolong the QT interval.

How to manage the interaction:
Taking Tasibenz-150 Capsule 28's with Sparfloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibYellow fever vaccine
Critical
How does the drug interact with Tasibenz-150 Capsule 28's:
Combining Yellow fever vaccine with Tasibenz-150 Capsule 28's can increase the risk of infection.

How to manage the interaction:
Taking Tasibenz-150 Capsule 28's with Yellow fever vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibRisperidone
Severe
How does the drug interact with Tasibenz-150 Capsule 28's:
Taking Risperidone and Tasibenz-150 Capsule 28's can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although there is a possible interaction between Tasibenz-150 Capsule 28's and Risperidone, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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NILOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NILOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the blood levels of Tasibenz-150 Capsule 28's, and increase the risk of an irregular heart rhythm. Consumption of grape juice and grape fruit should be avoided as is causes symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with Tasibenz-150 Capsule 28's. Food may also increase the blood levels of Tasibenz-150 Capsule 28's. Therefore, you should take Tasibenz-150 Capsule 28's on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking Tasibenz-150 Capsule 28's.

Diet & Lifestyle Advise

  • Drink nutrient-rich liquids such as juices, shakes and soups if you have trouble swallowing solid food.
  • Eat frequently by opting for 4 to 6 smaller meals a day instead of 2 to 3 big meals.
  • Consume a variety of vegetables, including legumes.
  • Eat whole grains, whole fruits, and fat-free or low-fat dairy products.
  • Include a variety of proteins in the diet, such as lean meats, poultry, seafood, soy, beans, and eggs.
  • Use healthy oils such as olive oil.
  • Drink plenty of water to keep yourself hydrated.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Tasibenz-150 Capsule 28's Substitute

Substitutes safety advice
  • Knilonat 150 Capsule 10's

    75.15per tablet
  • Nilocap 150 Capsule 4's

    31.50per tablet
  • Ninlib 150 mg Capsule 30's

    103.87per tablet
  • Tasigna 150Mg Capsule

    by AYUR

    32489.60per tablet
  • Nilosure 150 Capsule 4's

    87.08per tablet
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Alcohol

Consult your doctor

The interaction of Tasibenz-150 Capsule 28's with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Tasibenz-150 Capsule 28's is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Tasibenz-150 Capsule 28's. Also, you are advised to use effective birth control measures during treatment with Tasibenz-150 Capsule 28's and for up to 2 weeks after the last dose of Tasibenz-150 Capsule 28's.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Tasibenz-150 Capsule 28's and for two weeks after the final dose. Inform your doctor if you are breastfeeding.

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Driving

Caution

If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.

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Liver

Caution

Inform your doctor if you have liver problems before taking Tasibenz-150 Capsule 28's. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Consult your doctor

Limited information is available on the use of Tasibenz-150 Capsule 28's in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Tasibenz-150 Capsule 28's.

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Children

Caution

Tasibenz-150 Capsule 28's is not recommended for children below 1 year of age as the safety and effectiveness were not established.

FAQs

Tasibenz-150 Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
Tasibenz-150 Capsule 28's contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.
You are not recommended to take antacids and Tasibenz-150 Capsule 28's at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Tasibenz-150 Capsule 28's. However, please consult a doctor before taking other medicines with Tasibenz-150 Capsule 28's.
You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Tasibenz-150 Capsule 28's as it may increase the amount of Nilotinib in the body and cause serious side effects.

Country of origin

India

Manufacturer/Marketer address

Admac Lifesciences(Oncology)
Other Info - TAS0056

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