SIGDOTH 25MG TABLET belongs to the class of tricyclic antidepressants used to treat depression. It is primarily used to treat depression that is unresponsive to other antidepressants or any other alternative treatment. It is also used to treat disorders related to anxiety. Depression is a mood disorder that affects day to day life of a person. A person may have symptoms such as feeling sad or feeling lost and might have mood swings. Anxiety is defined as an emotion that is characterized by feelings of tension, worried thoughts and symptoms like increased blood pressure. Anxiety disorder also includes panic disorder which is characterized by sudden feelings of terror.

SIGDOTH 25MG TABLET contains ‘Dothiepin’ that works by increasing the levels of chemical messengers responsible for stabilizing and elevating the mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. It provides relief from symptoms such as feelings of restlessness, irritability, tiredness, difficulty concentrating, feeling and sleep disturbances. It helps to carry out daily activities easily.

Take this medicine as prescribed by your doctor. In some cases, you may experience side effects such as increased heart rate, blurred vision, dizziness, dryness in the mouth and constipation. Most of these side effects of SIGDOTH 25MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

It is not recommended to take SIGDOTH 25MG TABLET if you are allergic to any contents of it. Do not stop taking this medicine without consulting your doctor, as it may lead to withdrawal symptoms. Do not take this medicine if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder or difficulty in sleeping (sleep apnea), severe liver disease or problem with alcohol or other prescription recreational drugs. Inform your doctor if you are planning to get pregnant, are pregnant or breastfeeding. SIGDOTH 25MG TABLET is not recommended for use in children. In elderly people, SIGDOTH 25MG TABLET may require dose adjustments. Do not take alcohol while using SIGDOTH 25MG TABLET as it increases the risk of side effects. SIGDOTH 25MG TABLET may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

SIGDOTH 25MG TABLET works by increasing the levels of chemical messengers that are responsible for stabilizing and elevating mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. SIGDOTH 25MG TABLET relieves symptoms such as restlessness, irritability, tiredness, difficulty concentrating and disturbances in sleep. It helps to carry out daily activities easily and improves the quality of life.

• Increased heart rate
• Arrhythmias
• Blurred vision
• Dizziness
• Dryness in the mouth
• Weight gain
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Weight gain
• Difficulty in urination
• Constipation

SIGDOTH 25MG TABLET should be given with extreme caution in patients having epilepsy (brain disorder in which brain activity becomes abnormal, causing seizures), impaired liver or kidney function, diabetes, decreased level of sodium in the blood, tendency to develop bleedings or bruises easily, patients receiving electroconvulsive treatment, having coronary heart disease, suffering or have suffered from heart problems or have recently had a heart attack, having a low resting heart-rate, having prolonged severe diarrhoea and vomiting (being sick) or using diuretics (water tablets), experiencing a fast or irregular heartbeat, fainting, collapse or dizziness on standing up, which may indicate abnormal functioning of the heart rate and having or previously had eye problems, such as certain kinds of glaucoma (increased pressure in the eye).

Drug-Drug Interactions: This medicine may interact with other anti-depressants (phenelzine, iproniazid, isocarboxazid, nialamide, imipramine, desipramine, tranylcypromine and moclobemide), medicines used to treat Parkinson's disease (selegiline). Taking the above medicines with SIGDOTH 25MG TABLET can increase the risk of side effects. It can also have an interaction with an antibiotic (linezolid), a medicine used in the treatment of the manic-depressive disorder (lithium), a medicine used to treat migraines (sumatriptan), a medicine used for severe pain such (as tramadol), medicines used for stomach ulcers (cimetidine, lansoprazole and omeprazole), a medicine used to treat fungal infections (fluconazole), a medicine used to reduce the risk of stroke (ticlopidine), a herbal remedy used for depression (Hypericum perforatum), blood-thinning medicines (warfarin, dipyridamole and phenprocoumon), antimalarials (mefloquine), medicines used for heart diseases (flecainide and propafenone). SIGDOTH 25MG TABLET may also interact with medicines that decrease blood levels of potassium or magnesium, as these increase the risk of life-threatening heart rhythm disorder.

Drug-Food Interactions: No interactions found. 

Drug-Disease Interactions: People who are overweight or obese (with a BMI greater than 25) should consult a doctor before taking SIGDOTH 25MG TABLET.

• PHENELZINE
• ISOCARBOXAZID
• IMIPRAMINE
• DESIPRAMINE
• TRANYLCYPROMINE
• MOCLOBEMIDE
• SELEGILINE
• LINEZOLID
• LITHIUM
• SUMATRIPTAN
• TRAMADOL
• CIMETIDINE
• LANSOPRAZOLE
• OMEPRAZOLE
• FLUCONAZOLE
• TICLOPIDINE
• HYPERICUM PERFORATUM
• WARFARIN
• DIPYRIDAMOLE
• PHENPROCOUMON
• MEFLOQUINE
• FLECAINIDE
• PROPAFENONE
• IPRONIAZID
• NIALAMIDE

• Opt for healthy food, which in turn will help you to elevate your moods.
• Exercise daily for at least 30 minutes a day. It will help you to reduce stress and improve your mood. It will also improve your quality of sleep.
• Take deep breaths to calm your mind.
• Follow a consistent sleep schedule (at least 8 hours a day).
• Manage your stress levels by doing activities that make you happy such as watching your favourite show, reading a book, listening to music and doing activities of your interest.

Do not stop taking SIGDOTH 25MG TABLET without consulting your doctor. You may experience side effects if you stop taking it suddenly. Your doctor will most likely advise you to gradually reduce your dose over several weeks before completely discontinuing it.

Depression: It is a mood disorder that has an impact on a person's daily life. Symptoms such as melancholy or loss, as well as mood changes, may occur.

Anxiety: It is characterised by tension, anxious thoughts, and symptoms such as elevated blood pressure. Panic disorder is a type of anxiety disorder marked by unexpected feelings of terror.