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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Poshope 40 Suspension is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

POSACONAZOLE-40MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Poshope 40 Suspension

Poshope 40 Suspension is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Poshope 40 Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Poshope 40 Suspension as prescribed by your doctor. You are advised to take Poshope 40 Suspension for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Poshope 40 Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Poshope 40 Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Poshope 40 Suspension only if the benefits outweigh the risk. Before taking the Poshope 40 Suspension , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Poshope 40 Suspension

Poshope 40 Suspension is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Posaconazole is an antifungal medication present in Poshope 40 Suspension . It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

How Poshope 40 Suspension Works

Poshope 40 Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Poshope 40 Suspension

  • Diarrhoea
  • Nausea
  • Fever
  • Vomiting
  • Headache
  • Coughing
  • Low potassium levels in the blood

What if I have taken an overdose of Poshope 40 Suspension

Take Poshope 40 Suspension only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in Poshope 40 Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Poshope 40 Suspension only if the benefits outweigh the risk. Before taking the Poshope 40 Suspension , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Poshope 40 Suspension if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions

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PosaconazoleIsavuconazole
Critical
PosaconazolePimozide
Critical

Drug-Drug Interactions

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PosaconazoleIsavuconazole
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
When Isavuconazole is taken with Poshope 40 Suspension 105 ml, it can increase the levels of isavuconazole in the blood.

How to manage the interaction:
Although there is an interaction between isavuconazole and Poshope 40 Suspension 105 ml, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazolePimozide
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Taking pimozide with Poshope 40 Suspension 105 ml can increase the levels of pimozide in the blood, which can lead to an increased risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Poshope 40 Suspension 105 ml and pimozide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe or prolonged diarrhea, vomiting dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleZiprasidone
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Coadministration of Poshope 40 Suspension 105 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Poshope 40 Suspension 105 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleSimvastatin
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Taking Poshope 40 Suspension 105 ml with Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver problems and rhabdomyolysis (which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Poshope 40 Suspension 105 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleAtorvastatin
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Taking atorvastatin with Poshope 40 Suspension 105 ml can increase the blood levels of atorvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Poshope 40 Suspension 105 ml with atorvastatin, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
PosaconazoleIvabradine
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Using ivabradine together with Poshope 40 Suspension 105 ml may significantly increase the blood levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Poshope 40 Suspension 105 ml together is generally not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
PosaconazoleConivaptan
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
When Poshope 40 Suspension 105 ml is taken with Conivaptan, it can increase the blood levels and effects of conivaptan.

How to manage the interaction:
Although there is an interaction between Poshope 40 Suspension 105 ml and conivaptan, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, or mood changes. Do not discontinue any medications without consulting a doctor.
PosaconazoleEliglustat
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Taking eliglustat with Poshope 40 Suspension 105 ml can increase the levels of eliglustat in the blood.

How to manage the interaction:
Although there is an interaction between Poshope 40 Suspension 105 ml and eliglustat, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, a slow heart rate, or a weak pulse. Do not discontinue any medications without consulting a doctor.
PosaconazoleDronedarone
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
When Dronedarone is taken with Poshope 40 Suspension 105 ml, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Poshope 40 Suspension 105 ml with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleLurasidone
Critical
How does the drug interact with Poshope 40 Suspension 105 ml:
Taking lurasidone together with Poshope 40 Suspension 105 ml may result in significantly higher lurasidone blood levels.

How to manage the interaction:
Although there is an interaction between lurasidone and Poshope 40 Suspension 105 ml, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, dizziness, lightheadedness, headache, flushing, or fainting. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Poshope 40 Suspension for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Poshope 40 Suspension .
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Poshope 40 Suspension treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Poshope 40 Suspension Substitute

Substitutes safety advice
  • Picasa Oral Suspension 105 ml

    by AYUR

    160.17per tablet
  • Noxafil Oral Suspension 105 ml

    171.81per tablet
  • Viposan Oral Suspension 105 ml

    179.62per tablet
  • Posanex Oral Suspension 105 ml

    155.02per tablet
  • Poscosafe Oral Suspension 105 ml

    183.52per tablet
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Alcohol

Consult your doctor

The interaction of Poshope 40 Suspension with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Poshope 40 Suspension should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Poshope 40 Suspension .

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Breast Feeding

Consult your doctor

There is no substantial research yet on using Poshope 40 Suspension in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Poshope 40 Suspension ; your doctor will decide whether Poshope 40 Suspension can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Poshope 40 Suspension alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the Poshope 40 Suspension if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Poshope 40 Suspension if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Please consult a doctor before using Poshope 40 Suspension for children.

FAQs

Poshope 40 Suspension is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.
Poshope 40 Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.
Poshope 40 Suspension is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Poshope 40 Suspension .
If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.
Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of Poshope 40 Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Take Poshope 40 Suspension as prescribed by your doctor. You are advised to take Poshope 40 Suspension for as long as your doctor has prescribed it for you based on your medical condition.

Country of origin

INDIA

Manufacturer/Marketer address

16Th Floor, Godrej Bkc, Plot €“ C, €Œg” Block, Bandra-Kurla Complex, Bandra (East), Mumbai €“ 400 051, India
Other Info - POS0078

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