Posapol Oral Suspension

Posapol Oral Suspension is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Posapol Oral Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Posapol Oral Suspension as prescribed by your doctor. You are advised to take Posapol Oral Suspension for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Posapol Oral Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Posapol Oral Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posapol Oral Suspension only if the benefits outweigh the risk. Before taking the Posapol Oral Suspension, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Posaconazole is an antifungal medication present in Posapol Oral Suspension. It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

• Diarrhoea
• Nausea
• Fever
• Vomiting
• Headache
• Coughing
• Low potassium levels in the blood

Inform your doctor if you are allergic or hypersensitive to any component present in Posapol Oral Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posapol Oral Suspension only if the benefits outweigh the risk. Before taking the Posapol Oral Suspension, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Posapol Oral Suspension if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions: Posapol Oral Suspension may interact with various drugs, including medicines used to treat allergies (terfenadine, astemizole), drug used to treat stomach problems (cisapride), medicine used to treat symptoms of Tourette's and mental illness (pimozide), antimalarial drug (halofantrine), and medicine used to treat abnormal heart rhythms (quinidine).

Drug-Food Interactions: There are no studies indicating food interactions with Posapol Oral Suspension. However, it is advised to take non-starchy vegetables and gluten-free foods and limit alcohol and caffeine intake.

Drug-Disease Interactions: Tell your doctor before taking Posapol Oral Suspension if you have a medical history of allergic reactions to medicines, heart diseases, liver or kidney problems, blood disorders and low levels of magnesium and potassium.

• TERFENADINE
• ASTEMIZOLE
• CISAPRIDE
• PIMOZIDE
• HALOFANTRINE
• QUINIDINE

• Take the medication as directed by the doctor and at regular intervals if you take Posapol Oral Suspension for more than one day.
• Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Posapol Oral Suspension.
• Continue taking your normal regular diet unless your doctor prescribes a specific diet.
• It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
• A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Posapol Oral Suspension treatment to enhance a healthy lifestyle practice.

• Regular blood tests are recommended before and while taking Posapol Oral Suspension to monitor liver functioning, especially if you have any liver problems.

Fungal infection: Fungal infection occurs when a fungus enters, infects, and multiplies in the body. Fungi can live in water, soil, air, and plants. Fungi affect any body part, including the mouth, throat, oesophagus, lungs, bladder, genital area, and blood. Mild fungal skin infections are common and can cause rashes. Fungal infections affecting body organs like the lungs can cause flu or tuberculosis. Some fungal diseases like cryptococcal meningitis and blood infections can be fatal. A few common fungal infections are yeast infections that affect the genital area, oesophagus, and urinary tract caused by Candida.

Invasive aspergillosis: Invasive aspergillosis occurs when Aspergillus causes serious infection and usually affects people with weakened immune systems, such as those who have had an organ transplant or a stem cell transplant. Invasive aspergillosis most commonly affects the lungs but can also spread to other body parts.