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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Noxafil Oral Suspension is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

POSACONAZOLE-40MG

Manufacturer/Marketer :

Msd Pharmaceutical Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Noxafil Oral Suspension

Noxafil Oral Suspension is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Noxafil Oral Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Noxafil Oral Suspension as prescribed by your doctor. You are advised to take Noxafil Oral Suspension for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Noxafil Oral Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Noxafil Oral Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Noxafil Oral Suspension only if the benefits outweigh the risk. Before taking the Noxafil Oral Suspension , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Noxafil Oral Suspension

Noxafil Oral Suspension is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Directions for Use

Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Posaconazole is an antifungal medication present in Noxafil Oral Suspension . It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

How Noxafil Oral Suspension Works

Noxafil Oral Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Noxafil Oral Suspension

  • Diarrhoea
  • Nausea
  • Fever
  • Vomiting
  • Headache
  • Coughing
  • Low potassium levels in the blood

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in Noxafil Oral Suspension or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Noxafil Oral Suspension only if the benefits outweigh the risk. Before taking the Noxafil Oral Suspension , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Noxafil Oral Suspension if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions

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PosaconazoleTicagrelor
Critical
PosaconazoleDronedarone
Critical

Drug-Drug Interactions

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PosaconazoleTicagrelor
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Co-administration of Noxafil Oral Suspension 105 ml with Ticagrelor can increase the risk of bleeding.

How to manage the interaction:
Taking Ticagrelor with Noxafil Oral Suspension 105 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
PosaconazoleDronedarone
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
When Dronedarone is taken with Noxafil Oral Suspension 105 ml, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Noxafil Oral Suspension 105 ml with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleAtorvastatin
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Taking atorvastatin with Noxafil Oral Suspension 105 ml can increase the blood levels of atorvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Noxafil Oral Suspension 105 ml with atorvastatin, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
PosaconazoleLovastatin
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Taking lovastatin with Noxafil Oral Suspension 105 ml can increase the levels of lovastatin in the blood which can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Lovastatin and Noxafil Oral Suspension 105 ml, they can be taken together if advised by a doctor. However, contact a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
PosaconazolePimozide
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Taking pimozide with Noxafil Oral Suspension 105 ml can increase the levels of pimozide in the blood, which can lead to an increased risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Noxafil Oral Suspension 105 ml and pimozide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe or prolonged diarrhea, vomiting dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleConivaptan
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
When Noxafil Oral Suspension 105 ml is taken with Conivaptan, it can increase the blood levels and effects of conivaptan.

How to manage the interaction:
Although there is an interaction between Noxafil Oral Suspension 105 ml and conivaptan, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, or mood changes. Do not discontinue any medications without consulting a doctor.
PosaconazoleEplerenone
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Coadministration of Noxafil Oral Suspension 105 ml with eplerenone can increase the blood levels of eplerenone. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between Noxafil Oral Suspension 105 ml and eplerenone, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleEliglustat
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
Taking eliglustat with Noxafil Oral Suspension 105 ml can increase the levels of eliglustat in the blood.

How to manage the interaction:
Although there is an interaction between Noxafil Oral Suspension 105 ml and eliglustat, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, a slow heart rate, or a weak pulse. Do not discontinue any medications without consulting a doctor.
PosaconazoleCisapride
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
When Noxafil Oral Suspension 105 ml is taken with Cisapride, it can lower the rate at which Cisapride is broken down in the body.

How to manage the interaction:
Taking Noxafil Oral Suspension 105 ml with Cisapride is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PosaconazoleIsavuconazole
Critical
How does the drug interact with Noxafil Oral Suspension 105 ml:
When Isavuconazole is taken with Noxafil Oral Suspension 105 ml, it can increase the levels of isavuconazole in the blood.

How to manage the interaction:
Although there is an interaction between isavuconazole and Noxafil Oral Suspension 105 ml, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Noxafil Oral Suspension for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Noxafil Oral Suspension .
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Noxafil Oral Suspension treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Noxafil Oral Suspension Substitute

Substitutes safety advice
  • Picasa Oral Suspension 105 ml

    by AYUR

    160.17per tablet
  • Viposan Oral Suspension 105 ml

    179.62per tablet
  • Poscosafe Oral Suspension 105 ml

    183.52per tablet
  • Posanex Oral Suspension 105 ml

    155.02per tablet
  • Poshope 40 Suspension 105 ml

    180.28per tablet
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Alcohol

Consult your doctor

The interaction of Noxafil Oral Suspension with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Noxafil Oral Suspension should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Noxafil Oral Suspension .

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Breast Feeding

Consult your doctor

There is no substantial research yet on using Noxafil Oral Suspension in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Noxafil Oral Suspension ; your doctor will decide whether Noxafil Oral Suspension can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Noxafil Oral Suspension alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the Noxafil Oral Suspension if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Noxafil Oral Suspension if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Please consult a doctor before using Noxafil Oral Suspension for children.

FAQs

Noxafil Oral Suspension is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.
Noxafil Oral Suspension contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.
Noxafil Oral Suspension is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Noxafil Oral Suspension .
If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.
Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of Noxafil Oral Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Take Noxafil Oral Suspension as prescribed by your doctor. You are advised to take Noxafil Oral Suspension for as long as your doctor has prescribed it for you based on your medical condition.

Country of origin

United States

Manufacturer/Marketer address

Platina, 8th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,
Other Info - NOX0014

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