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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nindanib 150 Soft Gelatin Capsule is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

NINTEDANIB-150MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Nindanib 150 Soft Gelatin Capsule

Nindanib 150 Soft Gelatin Capsule belongs to the category of 'anti-fibrotic medicine', and it is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, which makes it difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.

Nindanib 150 Soft Gelatin Capsule contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Nindanib 150 Soft Gelatin Capsule helps in slowing down the progress of idiopathic pulmonary fibrosis.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Nindanib 150 Soft Gelatin Capsule if you are pregnant or breastfeeding. Nindanib 150 Soft Gelatin Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Nindanib 150 Soft Gelatin Capsule as it could lead to increased dizziness. Nindanib 150 Soft Gelatin Capsule is not recommended for children below 18 years as safety and effectiveness have not been established. Nindanib 150 Soft Gelatin Capsule is listed as pregnancy category D. Because Nindanib 150 Soft Gelatin Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Nindanib 150 Soft Gelatin Capsule . Consult your doctor if you are breastfeeding; your doctor will decide whether the Nindanib 150 Soft Gelatin Capsule can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Nindanib 150 Soft Gelatin Capsule

Treatment of Idiopathic pulmonary fibrosis

Directions for Use

Swallow Nindanib 150 Soft Gelatin Capsule as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Nindanib 150 Soft Gelatin Capsule is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Nindanib 150 Soft Gelatin Capsule can help effectively slow the rate of lung function decline by 50%. Nindanib 150 Soft Gelatin Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Nindanib 150 Soft Gelatin Capsule helps in slowing down the progress of idiopathic pulmonary fibrosis.

How Nindanib 150 Soft Gelatin Capsule Works

Nindanib 150 Soft Gelatin Capsule contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Nindanib 150 Soft Gelatin Capsule helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nindanib 150 Soft Gelatin Capsule

  • Diarrhoea
  • Feeling and being sick
  • Tummy (Abdominal) Pain
  • Loss of appetite and weight loss

What if I have taken an overdose of Nindanib 150 Soft Gelatin Capsule

Take Nindanib 150 Soft Gelatin Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not use Nindanib 150 Soft Gelatin Capsule if you are allergic to any components present in Nindanib 150 Soft Gelatin Capsule . Nindanib 150 Soft Gelatin Capsule is listed as pregnancy category D; because Nindanib 150 Soft Gelatin Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Nindanib 150 Soft Gelatin Capsule . Consult your doctor if you are breastfeeding; your doctor will decide whether the Nindanib 150 Soft Gelatin Capsule can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Nindanib 150 Soft Gelatin Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Nindanib 150 Soft Gelatin Capsule as it could lead to increased dizziness. Nindanib 150 Soft Gelatin Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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NintedanibFosphenytoin
Severe
NintedanibLomitapide
Severe

Drug-Drug Interactions

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NintedanibFosphenytoin
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Nindanib 150 Soft Gelatin Capsule with Fosphenytoin can reduce the levels of Nindanib 150 Soft Gelatin Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Nindanib 150 Soft Gelatin Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibLomitapide
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Co-administration of Lomitapide and Nindanib 150 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Nindanib 150 Soft Gelatin Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibRifapentine
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Nindanib 150 Soft Gelatin Capsule and Rifapentine can reduce the blood levels of Nindanib 150 Soft Gelatin Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nindanib 150 Soft Gelatin Capsule and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
NintedanibTipranavir
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Nindanib 150 Soft Gelatin Capsule and Tipranavir can reduce the blood levels of Nindanib 150 Soft Gelatin Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nindanib 150 Soft Gelatin Capsule and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
NintedanibTeriflunomide
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Teriflunomide and Nindanib 150 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Nindanib 150 Soft Gelatin Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.
NintedanibCarbamazepine
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Nindanib 150 Soft Gelatin Capsule with Carbamazepine can reduce the levels and effects of Nindanib 150 Soft Gelatin Capsule.

How to manage the interaction:
Although taking carbamazepine and Nindanib 150 Soft Gelatin Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibPrimidone
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Nindanib 150 Soft Gelatin Capsule and primidone can reduce the blood levels of Nindanib 150 Soft Gelatin Capsule.

How to manage the interaction:
Although there is an interaction between Nindanib 150 Soft Gelatin Capsule and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibPhenobarbital
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Taking Phenobarbital and Nindanib 150 Soft Gelatin Capsule can drastically lower Nindanib 150 Soft Gelatin Capsule levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Nindanib 150 Soft Gelatin Capsule can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
NintedanibPhenytoin
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Coadministration of Phenytoin and Nindanib 150 Soft Gelatin Capsule may decrease the blood levels of Nindanib 150 Soft Gelatin Capsule, which may reduce Nindanib 150 Soft Gelatin Capsule's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Nindanib 150 Soft Gelatin Capsule together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibLeflunomide
Severe
How does the drug interact with Nindanib 150 Soft Gelatin Capsule:
Co-administration of Leflunomide and Nindanib 150 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Nindanib 150 Soft Gelatin Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Nindanib 150 Soft Gelatin Capsule Substitute

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  • Idofnib-150 Capsule 10's

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  • Nindev 150 mg Softgel Capsule 10's

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  • Fibnib 150 Softgel Capsule 10's

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    97.20per tablet
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Alcohol

Caution

It is not known if alcohol interacts with Nindanib 150 Soft Gelatin Capsule . However, as a precautionary measure, you are recommended not to consume alcohol with the Nindanib 150 Soft Gelatin Capsule to avoid unpleasant side effects.

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Pregnancy

Unsafe

Nindanib 150 Soft Gelatin Capsule is listed as pregnancy category D. Because Nindanib 150 Soft Gelatin Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Nindanib 150 Soft Gelatin Capsule .

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Nindanib 150 Soft Gelatin Capsule can be taken by breastfeeding mothers or not.

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Driving

Caution

Nindanib 150 Soft Gelatin Capsule may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Caution

Dose adjustment may be needed. Nindanib 150 Soft Gelatin Capsule is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Caution

Dose adjustment may be needed. Nindanib 150 Soft Gelatin Capsule is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Caution

Nindanib 150 Soft Gelatin Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Nindanib 150 Soft Gelatin Capsule is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.

Nindanib 150 Soft Gelatin Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Avoid smoking before starting the treatment while taking Nindanib 150 Soft Gelatin Capsule as smoking might alter the effectiveness of Nindanib 150 Soft Gelatin Capsule .

Nindanib 150 Soft Gelatin Capsule should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Nindanib 150 Soft Gelatin Capsule until your doctor asks you to stop it.

If you have any surgery, including dental surgery, please inform your doctor if you are taking Nindanib 150 Soft Gelatin Capsule as your doctor might stop Nindanib 150 Soft Gelatin Capsule before undergoing surgery.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - NIN0043

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