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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mantedanib-150 Softgel Cap is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

NINTEDANIB-150MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Mantedanib-150 Softgel Cap

Mantedanib-150 Softgel Cap belongs to the category of 'anti-fibrotic medicine', and it is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, which makes it difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.

Mantedanib-150 Softgel Cap contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-150 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Mantedanib-150 Softgel Cap if you are pregnant or breastfeeding. Mantedanib-150 Softgel Cap may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Mantedanib-150 Softgel Cap as it could lead to increased dizziness. Mantedanib-150 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established. Mantedanib-150 Softgel Cap is listed as pregnancy category D. Because Mantedanib-150 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-150 Softgel Cap . Consult your doctor if you are breastfeeding; your doctor will decide whether the Mantedanib-150 Softgel Cap can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Mantedanib-150 Softgel Cap

Treatment of Idiopathic pulmonary fibrosis

Directions for Use

Swallow Mantedanib-150 Softgel Cap as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Mantedanib-150 Softgel Cap is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Mantedanib-150 Softgel Cap can help effectively slow the rate of lung function decline by 50%. Mantedanib-150 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-150 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.

How Mantedanib-150 Softgel Cap Works

Mantedanib-150 Softgel Cap contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-150 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mantedanib-150 Softgel Cap

  • Diarrhoea
  • Feeling and being sick
  • Tummy (Abdominal) Pain
  • Loss of appetite and weight loss

What if I have taken an overdose of Mantedanib-150 Softgel Cap

Take Mantedanib-150 Softgel Cap only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not use Mantedanib-150 Softgel Cap if you are allergic to any components present in Mantedanib-150 Softgel Cap . Mantedanib-150 Softgel Cap is listed as pregnancy category D; because Mantedanib-150 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-150 Softgel Cap . Consult your doctor if you are breastfeeding; your doctor will decide whether the Mantedanib-150 Softgel Cap can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Mantedanib-150 Softgel Cap may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Mantedanib-150 Softgel Cap as it could lead to increased dizziness. Mantedanib-150 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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NintedanibPrimidone
Severe
NintedanibLeflunomide
Severe

Drug-Drug Interactions

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NintedanibPrimidone
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S and primidone can reduce the blood levels of Mantedanib-150 Softgel Cap 10'S.

How to manage the interaction:
Although there is an interaction between Mantedanib-150 Softgel Cap 10'S and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibLeflunomide
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Co-administration of Leflunomide and Mantedanib-150 Softgel Cap 10'S can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Mantedanib-150 Softgel Cap 10'S can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibRifapentine
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S and Rifapentine can reduce the blood levels of Mantedanib-150 Softgel Cap 10'S.

How to manage the interaction:
There may be a possibility of interaction between Mantedanib-150 Softgel Cap 10'S and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
NintedanibPhenobarbital
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Taking Phenobarbital and Mantedanib-150 Softgel Cap 10'S can drastically lower Mantedanib-150 Softgel Cap 10'S levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Mantedanib-150 Softgel Cap 10'S can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
NintedanibTipranavir
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S and Tipranavir can reduce the blood levels of Mantedanib-150 Softgel Cap 10'S.

How to manage the interaction:
There may be a possibility of interaction between Mantedanib-150 Softgel Cap 10'S and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
NintedanibLomitapide
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Co-administration of Lomitapide and Mantedanib-150 Softgel Cap 10'S can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Mantedanib-150 Softgel Cap 10'S can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibCarbamazepine
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S with Carbamazepine can reduce the levels and effects of Mantedanib-150 Softgel Cap 10'S.

How to manage the interaction:
Although taking carbamazepine and Mantedanib-150 Softgel Cap 10'S together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibRifampicin
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S with Rifampicin can decrease the blood levels of Mantedanib-150 Softgel Cap 10'S, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Mantedanib-150 Softgel Cap 10'S and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
NintedanibPhenytoin
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Phenytoin and Mantedanib-150 Softgel Cap 10'S may decrease the blood levels of Mantedanib-150 Softgel Cap 10'S, which may reduce Mantedanib-150 Softgel Cap 10'S's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Mantedanib-150 Softgel Cap 10'S together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Mantedanib-150 Softgel Cap 10'S:
Coadministration of Mantedanib-150 Softgel Cap 10'S with Fosphenytoin can reduce the levels of Mantedanib-150 Softgel Cap 10'S. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Mantedanib-150 Softgel Cap 10'S and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Mantedanib-150 Softgel Cap Substitute

Substitutes safety advice
  • Nintena 150 Soft Gelatin Capsule 10's

    by AYUR

    88.92per tablet
  • Nintib 150 Soft Gelatin Capsule 10's

    92.57per tablet
  • Nindanib 150 Soft Gelatin Capsule 10's

    by AYUR

    106.43per tablet
  • Idofnib-150 Capsule 10's

    by AYUR

    107.64per tablet
  • Nindev 150 mg Softgel Capsule 10's

    by AYUR

    108.27per tablet
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Alcohol

Caution

It is not known if alcohol interacts with Mantedanib-150 Softgel Cap . However, as a precautionary measure, you are recommended not to consume alcohol with the Mantedanib-150 Softgel Cap to avoid unpleasant side effects.

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Pregnancy

Unsafe

Mantedanib-150 Softgel Cap is listed as pregnancy category D. Because Mantedanib-150 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-150 Softgel Cap .

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Mantedanib-150 Softgel Cap can be taken by breastfeeding mothers or not.

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Driving

Caution

Mantedanib-150 Softgel Cap may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Caution

Dose adjustment may be needed. Mantedanib-150 Softgel Cap is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Caution

Dose adjustment may be needed. Mantedanib-150 Softgel Cap is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Caution

Mantedanib-150 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Mantedanib-150 Softgel Cap is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.
Mantedanib-150 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.
Avoid smoking before starting the treatment while taking Mantedanib-150 Softgel Cap as smoking might alter the effectiveness of Mantedanib-150 Softgel Cap .
Mantedanib-150 Softgel Cap should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Mantedanib-150 Softgel Cap until your doctor asks you to stop it.
If you have any surgery, including dental surgery, please inform your doctor if you are taking Mantedanib-150 Softgel Cap as your doctor might stop Mantedanib-150 Softgel Cap before undergoing surgery.
In elderly patients, the risk of side effects is more if you are taking Mantedanib-150 Softgel Cap . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase 3, New Delhi - 110020.
Other Info - MAN0480

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