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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Nebifast H 5mg/12.5mg Tablet is used to treat hypertension (high blood pressure) and reduce the risk of stroke in patients with high blood pressure. It is a combination medication generally used when a single medicine cannot control high blood pressure. It contains Nebivolol and Hydrochlorothiazide, which lowers heart rate and makes the heart more efficient at pumping blood throughout the body. It removes excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time. Thus, lowers blood pressure. It may cause side effects such as nausea, constipation, diarrhoea, fatigue, headache, dizziness, decreased potassium level in the blood, breathlessness, swelling of hands and feet, or paresthesia (burning sensation of the skin).

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About Nebifast H 5mg/12.5mg Tablet

Nebifast H 5mg/12.5mg Tablet is used to treat hypertension (high blood pressure) and reduce the risk of stroke in patients with high blood pressure. Nebifast H 5mg/12.5mg Tablet is a combination medication generally used when a single medicine cannot control high blood pressure. Hypertension or high blood pressure is a life-long or chronic condition in which the force exerted against the artery wall becomes too high. It can lead to the risk of heart diseases like heart attack and stroke.

Nebifast H 5mg/12.5mg Tablet contains nebivolol and hydrochlorothiazide. Nebivolol is a beta blocker that works on the heart, particularly to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time.

You may experience nausea, constipation, diarrhoea, fatigue, headache, dizziness, decreased potassium level in the blood, increased blood uric acid, altered blood lipid level, breathlessness, swelling of hands & feet, paresthesia (burning sensation of the skin), decreased magnesium level in the blood, increased calcium level in blood. Most of these side effects of Nebifast H 5mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Nebifast H 5mg/12.5mg Tablet if you are allergic to any of its components. Before taking Nebifast H 5mg/12.5mg Tablet, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. It is recommended not to take Nebifast H 5mg/12.5mg Tablet if you are pregnant or breastfeeding.

Uses of Nebifast H 5mg/12.5mg Tablet

Treatment of Hypertension (high blood pressure).

Directions for Use

Swallow Nebifast H 5mg/12.5mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Nebifast H 5mg/12.5mg Tablet is a combination of Nebivolol (beta-blockers/ blood pressure-lowering medicines) and Hydrochlorothiazide (thiazide diuretic or water pill). Nebivolol is a beta blocker that works on the heart specifically to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time. Thus Nebifast H 5mg/12.5mg Tablet lowers blood pressure and prevents the risk of stroke, heart attack and oedema (fluid overload).

How Nebifast H 5mg/12.5mg Tablet Works

Nebifast H 5mg/12.5mg Tablet contains nebivolol and hydrochlorothiazide. Nebivolol is a beta blocker that works on the heart, particularly to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nebifast H 5mg/12.5mg Tablet

  • Nausea
  • Constipation
  • Diarrhoea
  • Fatigue
  • Headache
  • Dizziness
  • Decreased potassium level in the blood
  • Increased blood uric acid
  • Altered blood lipid level
  • Breathlessness
  • Swelling of hands & feet
  • Paresthesia (burning sensation of the skin)
  • Decreased magnesium level in the blood
  • Increased calcium level in the blood

What if I have taken an overdose of Nebifast H 5mg/12.5mg Tablet

Do not take more than the prescribed dose of Nebifast H 5mg/12.5mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Before using Nebifast H 5mg/12.5mg Tablet, inform your doctor if you have liver disease, kidney disease, eye problem (glaucoma), asthma, increased uric acid level (gout), diabetes, hyperlipidemia (increased level of lipid) or hyperthyroidism (increased level of thyroid). Nebifast H 5mg/12.5mg Tablet should not be given to people allergic to Nebifast H 5mg/12.5mg Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. It is contraindicated in low blood pressure (hypotension) and aortic stenosis (heart valve problem). Nebifast H 5mg/12.5mg Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Nebifast H 5mg/12.5mg Tablet and breastfeeding.

Drug-Drug Interactions

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HydrochlorothiazideDofetilide
Critical
HydrochlorothiazideCisapride
Critical

Drug-Drug Interactions

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HydrochlorothiazideDofetilide
Critical
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Taking Dofetilide and Nebifast H 5mg/12.5mg Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Dofetilide and Nebifast H 5mg/12.5mg Tablet together is not recommended as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
HydrochlorothiazideCisapride
Critical
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Taking Cisapride and Nebifast H 5mg/12.5mg Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Nebifast H 5mg/12.5mg Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NebivololTheophylline
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Combined use of Nebifast H 5mg/12.5mg Tablet with Theophylline may increase the effect of Theophylline.

How to manage the interaction:
Although there is a possible interaction between Theophylline and Nebifast H 5mg/12.5mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, insomnia, tremors, restlessness, irregular heartbeats, contact a doctor. Do not discontinue any medications without a doctor's advice.
NebivololClonidine
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Co-administration of clonidine and Nebifast H 5mg/12.5mg Tablet together may lower blood pressure and slow your heart rate.

How to manage the interaction:
Taking clonidine and Nebifast H 5mg/12.5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololSaquinavir
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Using saquinavir together with Nebifast H 5mg/12.5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking saquinavir together with Nebifast H 5mg/12.5mg Tablet can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, slow pulse, irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
NebivololTheophylline
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Coadministration of Nebifast H 5mg/12.5mg Tablet with Theophylline may reduce the effect of Nebifast H 5mg/12.5mg Tablet.

How to manage the interaction:
Taking Nebifast H 5mg/12.5mg Tablet with Theophylline together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololFingolimod
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Taking Fingolimod and Nebifast H 5mg/12.5mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Fingolimod and Nebifast H 5mg/12.5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, shortness of breath, chest pain, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololCeritinib
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Coadministration ceritinib with Nebifast H 5mg/12.5mg Tablet can slow your heart rate and increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking ceritinib with Nebifast H 5mg/12.5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololAtazanavir
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Coadministration of atazanavir with Nebifast H 5mg/12.5mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking atazanavir with Nebifast H 5mg/12.5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, or irregular heartbeat consult a doctor. Do not discontinue any medications without a doctor's advice.
NebivololVerapamil
Severe
How does the drug interact with Nebifast H 5mg/12.5mg Tablet:
Using verapamil together with Nebifast H 5mg/12.5mg Tablet can lower the blood pressure and slow your heart rate.

How to manage the interaction:
Taking verapamil together with Nebifast H 5mg/12.5mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience fatigue, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. contact a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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NEBIVOLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MGPotassium rich foods, Calcium rich foods
Moderate

Drug-Food Interactions

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NEBIVOLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MGPotassium rich foods, Calcium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt, Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese

How to manage the interaction:
Consumption of Nebifast H 5mg/12.5mg Tablet with calcium rich food may decrease the effectiveness of Hydrochlorothiazide. Increase consumption of potassium-rich foods with Nebifast H 5mg/12.5mg Tablet may cause potassium depletion (low potassium level). Avoid consumption of potassium, calcium rich foods while being treated with Nebifast H 5mg/12.5mg Tablet.

Diet & Lifestyle Advise

  • Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol consumption.
  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Nebifast H 5mg/12.5mg Tablet Substitute

Substitutes safety advice
  • Nebicard H Tablet 15's

    18.66per tablet
  • Nebistar-H Tablet 15's

    by AYUR

    19.59per tablet
  • Nebi H Tablet 10's

    10.35per tablet
  • Nebilong-H Tablet 10's

    11.43per tablet
  • Nodon H Tablet 10's

    17.78per tablet
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Alcohol

Unsafe

You are recommended not to consume alcohol and Nebifast H 5mg/12.5mg Tablet to avoid unpleasant side effects like drowsiness and dizziness.

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Pregnancy

Unsafe

Nebifast H 5mg/12.5mg Tablet is not recommended during pregnancy. Nebifast H 5mg/12.5mg Tablet contains hydrochlorothiazide that crosses the placenta. This may cause fetal damage and can affect the unborn baby (fetus).

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Breast Feeding

Unsafe

Tell your doctor if you are breast-feeding or about to start breast-feeding. Nebifast H 5mg/12.5mg Tablet is not recommended for mothers who are breast-feeding.

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Driving

Caution

Nebifast H 5mg/12.5mg Tablet usually causes drowsiness and dizziness, affecting your ability to drive or operate machinery.

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Liver

Caution

Nebifast H 5mg/12.5mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Nebifast H 5mg/12.5mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Caution

Limited information is available regarding the usage of Nebifast H 5mg/12.5mg Tablet in children, so please consult a doctor if you have any concerns.

FAQs

Nebifast H 5mg/12.5mg Tablet is used to treat hypertension (high blood pressure) and reduce the risk of stroke in patients with high blood pressure.
Nebifast H 5mg/12.5mg Tablet contains nebivolol and hydrochlorothiazide. Nebivolol is a beta blocker that works on the heart to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time.
Nebifast H 5mg/12.5mg Tablet can be safely taken as long as your doctor has prescribed it. Conditions such as high blood pressure are life-long, and one should not abruptly discontinue them without discussing them with a doctor.
If you have missed a dose of Nebifast H 5mg/12.5mg Tablet, you are advised to take it as soon as you remember. However, try not to miss a dose in the first place. If it is time for you to take your next dose, do not take both doses together. Take only one dose; taking a double dose of Nebifast H 5mg/12.5mg Tablet will lead to low blood pressure.
Yes, Nebifast H 5mg/12.5mg Tablet can cause dizziness. Avoid driving or operating any heavy machinery while taking Nebifast H 5mg/12.5mg Tablet. In case you feel dizzy or lightheaded, rest for some time until you feel better.
No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending on your current blood pressure readings, your doctor may lower your medicine dosage and not recommend discontinuing it.
The best time to take Nebifast H 5mg/12.5mg Tablet is morning or evening as advised by the doctor based on your medical condition.
Nebifast H 5mg/12.5mg Tablet can be taken with food or without food as recommended by the doctor.
Nebifast H 5mg/12.5mg Tablet consists of hydrochlorothiazide and nebivolol. Hydrochlorothiazide is a thiazide diuretic and nebivolol is a beta blocker. This medication is used for the treatment of hypertension (high blood pressure) and reduces the risk of stroke in patients with high blood pressure.
Nebifast H 5mg/12.5mg Tablet should be taken orally. Swallow the medicine as a whole with water, do not crush, break or chew it.
The side effects of Nebifast H 5mg/12.5mg Tablet include constipation, diarrhoea, nausea, fatigue, headache, dizziness, decreased potassium level in the blood, altered blood lipid level, increased blood uric acid, increased calcium level in blood, breathlessness, swelling of hands & feet, paraesthesia (burning sensation of the skin), and decreased magnesium level in the blood. Consult the doctor if any of these side effects persist or worsen.
You should be cautious while taking Nebifast H 5mg/12.5mg Tablet if you have kidney disease, liver disease, asthma, diabetes, eye problem (glaucoma), increased uric acid level (gout), hyperlipidaemia (increased lipid level) or hyperthyroidism (increased thyroid level). Consult the doctor before taking Nebifast H 5mg/12.5mg Tablet if you have any of these health conditions.
Consult the doctor before taking other medications with Nebifast H 5mg/12.5mg Tablet, particularly diuretics, blood pressure-lowering medications (amiodarone, clonidine, diltiazem, amlodipine, digoxin, disopyramide), antispasmodic medications (baclofen), medications for mental illness (amisulpiride, haloperidol, chlorpromazine), depression medications (amitriptyline, paroxetine, fluoxetine), anti-cancer medications (cyclophosphamide, methotrexate, fluorouracil), mood stabilizers (lithium), angina medications (bepridil), blood sugar-lowering medications (insulin, metformin), gout medications (allopurinol, sulfinpyrazone, probenecid), and medications used to treat low blood pressure medications (noradrenaline).
Nebifast H 5mg/12.5mg Tablet should be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Plot No.-106, EPIP-II Thana Pind Baddi Pincode-173205
Other Info - NE83206

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