Nebisis H 5mg/12.5mg Tablet is used to treat hypertension (high blood pressure) and reduce the risk of stroke in patients with high blood pressure. Nebisis H 5mg/12.5mg Tablet is a combination medication generally used when a single medicine cannot control high blood pressure. Hypertension or high blood pressure is a life-long or chronic condition in which the force exerted against the artery wall becomes too high. It can lead to the risk of heart diseases like heart attack and stroke.

Nebisis H 5mg/12.5mg Tablet contains nebivolol and hydrochlorothiazide. Nebivolol is a beta blocker that works on the heart, particularly to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time.

You may experience nausea, constipation, diarrhoea, fatigue, headache, dizziness, decreased potassium level in the blood, increased blood uric acid, altered blood lipid level, breathlessness, swelling of hands & feet, paresthesia (burning sensation of the skin), decreased magnesium level in the blood, increased calcium level in blood. Most of these side effects of Nebisis H 5mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Nebisis H 5mg/12.5mg Tablet if you are allergic to any of its components. Before taking Nebisis H 5mg/12.5mg Tablet, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. It is recommended not to take Nebisis H 5mg/12.5mg Tablet if you are pregnant or breastfeeding.

Nebisis H 5mg/12.5mg Tablet is a combination of Nebivolol (beta-blockers/ blood pressure-lowering medicines) and Hydrochlorothiazide (thiazide diuretic or water pill). Nebivolol is a beta blocker that works on the heart specifically to lower heart rate and make the heart more efficient at pumping blood throughout the body. The diuretic hydrochlorothiazide lowers blood pressure by removing excess water and electrolytes from the body. It also relaxes blood vessels and improves blood flow over time. Thus Nebisis H 5mg/12.5mg Tablet lowers blood pressure and prevents the risk of stroke, heart attack and oedema (fluid overload).

• Nausea
• Constipation
• Diarrhoea
• Fatigue
• Headache
• Dizziness
• Decreased potassium level in the blood
• Increased blood uric acid
• Altered blood lipid level
• Breathlessness
• Swelling of hands & feet
• Paresthesia (burning sensation of the skin)
• Decreased magnesium level in the blood
• Increased calcium level in the blood

Before using Nebisis H 5mg/12.5mg Tablet, inform your doctor if you have liver disease, kidney disease, eye problem (glaucoma), asthma, increased uric acid level (gout), diabetes, hyperlipidemia (increased level of lipid) or hyperthyroidism (increased level of thyroid). Nebisis H 5mg/12.5mg Tablet should not be given to people allergic to Nebisis H 5mg/12.5mg Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. It is contraindicated in low blood pressure (hypotension) and aortic stenosis (heart valve problem). Nebisis H 5mg/12.5mg Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Nebisis H 5mg/12.5mg Tablet and breastfeeding.

Drug-Drug Interactions: Nebisis H 5mg/12.5mg Tablet may interact with other diuretics, blood pressure-lowering drugs (amiodarone, amlodipine, clonidine, digoxin, diltiazem, disopyramide), mental illness medications (amisulpiride, chlorpromazine, haloperidol), depression medications (amitriptyline, fluoxetine, paroxetine), antispasmodic medication (baclofen), anti-cancer medications (cyclophosphamide, fluorouracil, methotrexate), mood stabilizer (lithium), angina medication (bepridil), blood sugar-lowering medicines (insulin and oral antidiabetic drugs, metformin), medicines for gout (allopurinol, probenecid, sulfinpyrazone), drugs used to treat low blood pressure or slow heart rate (noradrenaline). If you are taking any of the above, speak with your doctor.

Drug-Food Interactions: You are recommended not to consume alcohol with a Nebisis H 5mg/12.5mg Tablet to avoid unpleasant side effects.

Drug-Disease Interactions: Nebisis H 5mg/12.5mg Tablet may interact with disease conditions, including liver function impairment, Anuria (severe renal insufficiency), cardiovascular diseases, Hypotension, bronchospasm (bronchial asthma), abnormal levels of potassium, calcium, sodium and symptomatic hyperuricemia (excess of uric acid in the blood).

• AMIODARONE
• AMLODIPINE
• CLONIDINE
• DIGOXIN
• DILTIAZEM
• DISOPYRAMIDE
• AMISULPRIDE
• CHLORPROMAZINE
• HALOPERIDOL
• AMITRIPTYLINE
• FLUOXETINE
• PAROXETINE
• BACLOFEN
• CYCLOPHOSPHAMIDE
• FLUOROURACIL
• METHOTREXATE
• LITHIUM
• INSULIN
• METFORMIN
• ALLOPURINOL
• PROBENECID
• SULFINPYRAZONE

• Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
• Keep your weight under control with a BMI of 19.5-24.9.
• Avoid chronic stress, as it can raise your blood pressure.
• Spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Be mindful of salt; consume no more than 2,300 mg each day.
• Limit or avoid alcohol consumption.
• Quitting smoking is the best strategy to lower the risk of heart disease.

Your doctor may advice regular blood sugar monitoring as Nebisis H 5mg/12.5mg Tablet may cause changes in your blood sugar levels.

Hypertension: The blood exerts increased pressure on the walls of blood vessels, leading to hypertension. High blood pressure is expressed as systolic/diastolic pressure. Systolic pressure is the pressure in the arteries when the heart beats or pumps out blood. Diastolic pressure is the pressure in the arteries between the heartbeats. Blood pressure is measured in millimetres of mercury (mmHg) by a blood pressure monitor called a sphygmomanometer. Some of the symptoms are headache, dizziness, nosebleeds, altered vision, chest pain, weakness, and shortness of breath. However, most of the time, there are no signs or symptoms of hypertension.