N-Dipine 10 mg Infusion 50 ml belongs to a group of medicines called calcium channel blockers indicated as prophylaxis and treatment of ischaemic neurological deficits caused by narrowing of blood vessels following subarachnoid haemorrhage of aneurysmal origin. Subarachnoid haemorrhage is the bleeding around the brain which is usually the result of bleeding from an aneurysm (a weakened area in a blood vessel).
 
N-Dipine 10 mg Infusion 50 ml contains ‘Nimodipine’ that relaxes the smooth muscles of the small blood vessels in the brain, thereby allowing narrowed blood vessels to open up. This helps in increasing blood flow & circulation, reduces blood pressure, and lowers the risk of damage caused by insufficient blood flow to the brain after bleeding.
 
In some cases, N-Dipine 10 mg Infusion 50 ml may cause side effects such as low blood pressure, vasodilation, nausea, constipation, flatulence, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant. Avoid breastfeeding while on treatment with N-Dipine 10 mg Infusion 50 ml. Drive or operate machinery only if you are alert as N-Dipine 10 mg Infusion 50 ml may cause dizziness. N-Dipine 10 mg Infusion 50 ml is not recommended for children below 18 years as safety and effectiveness have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

N-Dipine 10 mg Infusion 50 ml belongs to the group of medicines called calcium channel blockers indicated as prophylaxis and treatment of ischaemic neurological deficits caused by cerebral vasospasm (narrowing of blood vessels) following aneurysmal subarachnoid haemorrhage. N-Dipine 10 mg Infusion 50 ml contains ‘Nimodipine’ that relaxes the smooth muscles of the small blood vessels in the brain, thereby allowing narrowed blood vessels to open up. This helps in increasing blood flow & circulation, reduces blood pressure, and lowers the risk of damage caused by insufficient blood flow to the brain after bleeding.

• Low blood pressure
• Vasodilation
• Nausea
• Constipation
• Flatulence
• Diarrhoea

Do not take N-Dipine 10 mg Infusion 50 ml if you are allergic to any of its components. Inform your doctor if you have low blood pressure, fluid retention in the brain, bowel obstruction, epilepsy, alcoholism, heart kidney, or liver problems. Consult your doctor if you are pregnant. Avoid breastfeeding while on treatment with N-Dipine 10 mg Infusion 50 ml. Drive or operate machinery only if you are alert as N-Dipine 10 mg Infusion 50 ml may cause dizziness. N-Dipine 10 mg Infusion 50 ml is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions: N-Dipine 10 mg Infusion 50 ml may interact with antacid (cimetidine), anti-convulsant (phenobarbitone, phenytoin, carbamazepine, sodium valproate), anti-depressant (fluoxetine, nefazodone, nortriptyline), diuretic (furosemide), medicines used to treat tuberculosis (rifampicin), anti-HIV (indinavir, ritonavir, zidovudine), antibiotic (erythromycin, quinupristin+dalfopristin, aminoglycosides, cephalosporins).

Drug-Food Interactions: Avoid consuming grapefruit or its juice. Treatment with N-Dipine 10 mg Infusion 50 ml should not be started within 4 days of eating grapefruit or drinking grapefruit juice.

Drug-Disease Interactions: Inform your doctor if you have low blood pressure, fluid retention in the brain, bowel obstruction, epilepsy, alcoholism, or heart problems.

• CIMETIDINE
• PHENOBARBITONE
• PHENYTOIN
• CARBAMAZEPINE
• SODIUM VALPROATE
• FLUOXETINE
• NEFAZODONE
• NORTRIPTYLINE
• FUROSEMIDE
• RIFAMPICIN
• INDINAVIR
• RITONAVIR
• ZIDOVUDINE
• ERYTHROMYCIN
• QUINUPRISTIN+DALFOPRISTIN

• Avoid smoking and alcohol consumption.
• Maintain a healthy weight with proper diet and exercise.
• Include foods such as whole-grain bread, low-fat dairy products, lean meat, beans, and fish.
• Exercise as directed by the physician. It helps in lowering blood pressure, cholesterol, blood sugar and weight.
• Manage stress with meditation, music, or deep breathing.

• Regular monitoring of blood pressure levels and heart rate is advised.
• Your doctor may advise regular liver function tests, and blood tests to check your progress.

Subarachnoid haemorrhage: Subarachnoid haemorrhage is the bleeding in the subarachnoid space in the brain which is usually a result of bleeding from an aneurysm (a weakened area in the blood vessel). Subarachnoid space is the space where cerebrospinal fluid circulates, which protects the brain from injury. Due to haemorrhage, the blood supply to the brain is reduced, which leads to disruption of brain functions leading to its damage. The main symptom of subarachnoid haemorrhage is a sudden, severe headache. Other symptoms include neck pain, shoulder pain, confusion, seizures, irritability, double vision, and rapid loss of alertness.