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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 22, 2024 | 7:38 PM IST
Macova-5 Tablet 10's is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). It contains Letrozole, which prevents the growth of cancer cells. Thereby, it helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts. It may cause certain common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Prescription drug
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Composition

LETROZOLE-5MG

Manufacturer/Marketer

Gynofem Healthcare Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Macova-5 Tablet 10's

Macova-5 Tablet 10's belongs to the group of anti-cancer medicines called aromatase inhibitors used to treat breast cancer in women who have gone through menopause (cessation of menses periods). Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen.
 
Macova-5 Tablet 10's contains 'Letrozole' that works by blocking the aromatase enzyme, which is involved in the production of the estrogen hormone. The cancer cells require estrogen for their growth. Hence, by blocking the aromatase enzyme, Macova-5 Tablet 10's prevents the growth of cancer cells. Thereby Macova-5 Tablet 10's helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts.

You are advised to take Macova-5 Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, Macova-5 Tablet 10's may cause certain common side-effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Do not be reluctant to talk with your doctor if you experience any of these side-effects persistently.
 
Avoid taking Macova-5 Tablet 10's if you are pregnant or breastfeeding. Macova-5 Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Macova-5 Tablet 10's should not be given to children as safety has not been established. Avoid consuming alcohol along with Macova-5 Tablet 10's as it could lead to increased drowsiness and dizziness. Inform your doctor about your health condition and medications to rule out any side-effects.

Uses of Macova-5 Tablet 10's

Treatment of Breast cancer

Medicinal Benefits

Macova-5 Tablet 10's belongs to the group of anti-cancer medicines called aromatase inhibitors. Macova-5 Tablet 10's is used to treat breast cancer in women who have gone through menopause (cessation of periods). Macova-5 Tablet 10's works by blocking the aromatase enzyme, which is involved in the production of estrogens. The cancer cells require estrogen for their growth, so by blocking the enzyme Macova-5 Tablet 10's prevents the growth of cancer cells. Thereby, Macova-5 Tablet 10's helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.

Directions for Use

Take Macova-5 Tablet 10's with or without food. Swallow Macova-5 Tablet 10's as a whole with a glass of water; do not chew or break it. Take Macova-5 Tablet 10's at the same time every day.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Macova-5 Tablet 10's

  • Hypercholesterolemia (increased cholesterol levels)
  • Tiredness
  • Weakness
  • Increased sweating
  • Feeling unwell
  • Pain in joints
  • Hot flushes (feeling of warmth)

Drug Warnings

Do not take Macova-5 Tablet 10's if you are allergic to any of its contents, if you have not yet gone through menopause (still get your periods). Talk to your doctor before taking Macova-5 Tablet 10's if you have osteoporosis (thinning of bones), bone fractures, severe liver or kidney disease. Macova-5 Tablet 10's may cause inflammation in tendons or tendon injury; contact your doctor if you observe any sign of tendon pain or swelling while taking Macova-5 Tablet 10's. Avoid taking Macova-5 Tablet 10's if you are pregnant or breastfeeding. Macova-5 Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Macova-5 Tablet 10's should not be given to children as safety has not been established. Avoid consuming alcohol along with Macova-5 Tablet 10's as it could lead to increased drowsiness and dizziness. Inform your doctor about your health condition and medications before taking Macova-5 Tablet 10's to rule out any side-effects. 

Drug Interactions

Drug-Drug Interactions: Macova-5 Tablet 10's may interact with antidepressants (citalopram, escitalopram) and anticancer (tamoxifen). 

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have high cholesterol, osteoporosis (thinning of bone), or liver disease.

Drug-Drug Interactions Checker List

  • CITALOPRAM
  • ESCITALOPRAM
  • TAMOXIFEN

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.

  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.

  • Get optimal sleep; rest well.

Special Advise

  • Your doctor may advise you to regularly measure bone density before, during and after the treatment as Macova-5 Tablet 10's may cause bone thinning due to reduction of estrogens in the body.

  • Macova-5 Tablet 10's should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Macova-5 Tablet 10's.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in breast cells which are stimulated by the female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.  

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Macova-5 Tablet 10's to avoid unpleasant side effects. Alcohol intake, along with Macova-5 Tablet 10's, may cause increased drowsiness.

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Pregnancy

Unsafe

Macova-5 Tablet 10's is pregnancy category D medicine so, should not be taken during pregnancy.

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Breast Feeding

Unsafe

Macova-5 Tablet 10's should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby.

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Driving

Caution

Macova-5 Tablet 10's may cause dizziness and drowsiness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Safe if prescribed

It is safe to take Macova-5 Tablet 10's if prescribed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Safe if prescribed

It is safe to take Macova-5 Tablet 10's if prescribed. Please consult your doctor if you have kidney impairment or any concerns regarding this. No dosage adjustment is required for kidney patients with creatinine clearance greater than 10 mL/min.

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Children

Unsafe

Macova-5 Tablet 10's should not be used by children, as the efficacy and safety have not been established.

Country of origin

India

Manufacturer/Marketer address

Nand Vihar Colony, Narmada Road, Rau Tehsil ,Indore,Madhya Pradesh,453331
Other Info - MAC0521

Author Details

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FAQs

Macova-5 Tablet 10's belongs to the group of anti-cancer medicines used to treat breast cancer in women.
Macova-5 Tablet 10's works by blocking the aromatase enzyme, which is involved in the production of estrogens. The cancer cells require estrogen for their growth, so by blocking the enzyme Macova-5 Tablet 10's prevents the growth of cancer cells. Thereby, Macova-5 Tablet 10's helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.
Macova-5 Tablet 10's causes dizziness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.
High blood pressure could be a side-effect of Macova-5 Tablet 10's. Regularly monitor blood pressure levels while taking Macova-5 Tablet 10's. Consult your doctor if you regularly notice high blood pressure levels.
Do not stop taking Macova-5 Tablet 10's on your own. You are advised to take Macova-5 Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Macova-5 Tablet 10's.
Macova-5 Tablet 10's may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Macova-5 Tablet 10's.
Macova-5 Tablet 10's may cause weight gain due to an increase in appetite. Eat a healthy diet and exercise regularly to maintain proper weight.
Macova-5 Tablet 10's should be swallowed as a whole with water; do not crush or chew it.
Macova-5 Tablet 10's can be taken with or without food.
Macova-5 Tablet 10's should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Macova-5 Tablet 10's is prescribed to treat breast cancer in women who have gone through menopause.
Macova-5 Tablet 10's may cause high blood pressure. Therefore, irbesartan should be taken with Macova-5 Tablet 10's only if prescribed by the doctor. Regularly monitor blood pressure levels while taking Macova-5 Tablet 10's.
Macova-5 Tablet 10's may cause eye problems like blurred vision and cataracts. Consult the doctor if you experience blurred vision or eye irritation.
Macova-5 Tablet 10's may cause hot flushes leading to sweating. These symptoms usually improve during the first few months. However, if the symptoms persist or worsen, consult the doctor.
Serious side effects of Macova-5 Tablet 10's are difficulty breathing, chest pain, fainting, rapid heart rate, formation of blood clots (bluish skin discolouration, or sudden arm, leg or foot pain) and rupture of a tendon. These side effects are rare and may not occur in everyone taking Macova-5 Tablet 10's.
Letrozole may induce ovulation in anovulatory infertility patients and augment follicles for ovulatory women. However, it is an off-label use. Talk to the doctor if you have any concerns.
Macova-5 Tablet 10's is not recommended for use during pregnancy or while breastfeeding.
The time required for Macova-5 Tablet 10's to show its effects depends upon your condition and severity. Consult the doctor if you have any concerns.
If you miss a dose of Macova-5 Tablet 10's take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Macova-5 Tablet 10's may interact with antidepressants (citalopram, escitalopram) and anticancer medicines (tamoxifen). Let the doctor know if you are taking these medicines.
Store Macova-5 Tablet 10's at room temperature, in a dry place. Keep out of sight and reach of children.

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