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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Libset Tablet is an anti-cancer medicine used in the treatment of Breast cancer. It contains Lapatinib, which works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells; this causes inhibition of the cancer cell growth and, finally, initiation of apoptosis. It is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Libset Tablet

Libset Tablet is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Libset Tablet is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Libset Tablet contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Libset Tablet may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Libset Tablet should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Libset Tablet should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Libset Tablet . Libset Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Libset Tablet

Treatment of Breast Cancer

Directions for Use

Take Libset Tablet as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Libset Tablet contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

How Libset Tablet Works

Libset Tablet contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Libset Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Dry skin
  • Hair loss
  • Tiredness
  • Weakness
  • Headache
  • Fatigue

What if I have taken an overdose of Libset Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Libset Tablet may include severe diarrhea/vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Libset Tablet should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Libset Tablet may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Libset Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Libset Tablet should be given to children only if prescribed by the paediatrician. Libset Tablet is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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LapatinibAmiodarone
Severe
LapatinibClarithromycin
Severe

Drug-Drug Interactions

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LapatinibAmiodarone
Severe
How does the drug interact with Libset Tablet 30's:
Coadministration of Amiodarone together with Libset Tablet 30's may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Libset Tablet 30's interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.
LapatinibClarithromycin
Severe
How does the drug interact with Libset Tablet 30's:
Taking clarithromycin with Libset Tablet 30's may increase the blood levels of Libset Tablet 30's. This might make you more likely to develop side effects such as diarrhea, liver damage, and heart problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Libset Tablet 30's if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with Libset Tablet 30's. Do not stop using any medications without a doctor's advice.
LapatinibDisopyramide
Severe
How does the drug interact with Libset Tablet 30's:
The combined use of Libset Tablet 30's and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Libset Tablet 30's and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibMoxifloxacin
Severe
How does the drug interact with Libset Tablet 30's:
Using Moxifloxacin together with Libset Tablet 30's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Libset Tablet 30's, you can take these medicines together if prescribed by a doctor. If you experience irregular heart rhythm, dizziness, difficulty breathing, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LapatinibEscitalopram
Severe
How does the drug interact with Libset Tablet 30's:
Combining Libset Tablet 30's with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Co-administration of Escitalopram with Libset Tablet 30's can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience dizziness, fainting, abnormal heart rhythm, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LapatinibDigoxin
Severe
How does the drug interact with Libset Tablet 30's:
Co-administration of Digoxin and Libset Tablet 30's may increase the blood levels and effects of Digoxin.

How to manage the interaction:
If you are supposed to take Digoxin and Libset Tablet 30's together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive digoxin levels. Do not discontinue the medication without consulting a doctor.
LapatinibItraconazole
Severe
How does the drug interact with Libset Tablet 30's:
Using Libset Tablet 30's together with itraconazole may significantly increase the blood levels of Libset Tablet 30's.

How to manage the interaction:
Libset Tablet 30's and itraconazole may interact, but if a doctor prescribes them, you can still use them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and yellowing of the skin or eyes, diarrhoea, dizziness, lightheadedness, fainting, shortness of breath, or rapid or pounding heartbeats, seek medical attention. Never discontinue taking a medication without consulting a doctor.
LapatinibPosaconazole
Severe
How does the drug interact with Libset Tablet 30's:
Taking Libset Tablet 30's with posaconazole can increase the levels of Libset Tablet 30's in the blood, which can lead to an increased risk of side effects such as diarrhea, liver problems, and heart problems.

How to manage the interaction:
Although using Posaconazole and Libset Tablet 30's together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
LapatinibMorphine
Severe
How does the drug interact with Libset Tablet 30's:
Coadministration of Morphine with Libset Tablet 30's may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Libset Tablet 30's with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed and motor coordination, headaches, irritation, confusion, oedema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LapatinibSotalol
Severe
How does the drug interact with Libset Tablet 30's:
Taking Sotalol and Libset Tablet 30's can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Libset Tablet 30's, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Libset Tablet Substitute

Substitutes safety advice
  • Tykerb 250 mg Tablet 30's

    by AYUR

    300.30per tablet
  • Herduo Tablet 30's

    164.00per tablet
  • Combinib 250Mg Tablet 30'S

    by AYUR

    224.90per tablet
  • Tykerb 250 mg Tablet 6's

    1189.00per tablet
  • Herduo 250Mg Tablet 150'S

    by AYUR

    163.45per tablet
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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

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Pregnancy

Unsafe

Libset Tablet is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Libset Tablet . Use reliable methods of birth control while on treatment with Libset Tablet .

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Libset Tablet as it can cause serious side effects to the newborn baby.

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Driving

Consult your doctor

It is unknown whether Libset Tablet will affect your mental ability to drive or operate machines. Hence, consult your doctor for information regarding this.

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Liver

Caution

Inform your doctor if you have any pre-existing liver disease. Your doctor may adjust the dose of the medicine based on the condition. Libset Tablet is known to cause hepatotoxicity in some patients. If you notice any reactions such as itching, yellowing of the skin or eyes, dark urine, abdominal pain, unusual bleeding, or pale or dark stools, discontinue the treatment and inform your doctor immediately.

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Kidney

Caution

Limited data are available on the effect of Libset Tablet in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Libset Tablet is not recommended for use in children as the safety and efficacy are not established.

FAQs

Libset Tablet is used to treat breast cancer.
Libset Tablet contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other breast cancer treatment. Libset Tablet may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Libset Tablet .
Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Libset Tablet . Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.
Libset Tablet may cause side effects such as diarrhoea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
Libset Tablet is an anti-cancer medicine used in the treatment of breast cancer.
Yes, Libset Tablet can be given in combination with other anti-cancer drugs if prescribed by the doctor. Talk to the doctor if you have any concerns.
Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine. It should be taken one hour before or at least one hour after food.
Drink enough fluids and eat fibre-rich food if you experience diarrhoea. Consult the doctor if the diarrhoea persists or worsens.
Use sunscreen, soap-free cleanser and products that are free from fragrance and are hypoallergenic. Get your skin checked regularly by the doctor during treatment with Libset Tablet .
Before starting Libset Tablet , the doctor may advise heart and liver function tests.
Consult the doctor if you are planning for pregnancy after treatment with Libset Tablet . Use effective contraception during treatment with Libset Tablet and for a week after the last dose.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - LIB0098

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