DU Knib 250mg Tablet is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. DU Knib 250mg Tablet is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

DU Knib 250mg Tablet contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

DU Knib 250mg Tablet may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. DU Knib 250mg Tablet should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

DU Knib 250mg Tablet should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking DU Knib 250mg Tablet. DU Knib 250mg Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

DU Knib 250mg Tablet contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

• Nausea
• Vomiting
• Diarrhoea
• Myalgia
• Dry skin
• Hair loss
• Tiredness
• Weakness
• Headache
• Fatigue

DU Knib 250mg Tablet should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. DU Knib 250mg Tablet may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. DU Knib 250mg Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. DU Knib 250mg Tablet should be given to children only if prescribed by the paediatrician. DU Knib 250mg Tablet is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions: DU Knib 250mg Tablet may interact with CYP3A4 inhibitors (clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir, verapamil, diltiazem), CYP3A4 inducers (phenytoin, phenobarbitone, carbamazepine, rifampicin, st. john's wort), antiviral drugs (indinavir, efavirenz, atazanavir), etc.

Drug-Food Interactions: Avoid smoking and alcohol consumption.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, lung disease, or liver/kidney disease.

• CLARITHROMYCIN
• ERYTHROMYCIN
• KETOCONAZOLE
• RITONAVIR
• VERAMAPIL
• DILTIAZEM
• PHENYTOIN
• PHENOBARBITAL
• CARBAMAZEPINE
• ST JOHN'S WORT
• INDINAVIR
• EFAVIRENZ
• ITRACONAZOLE

• Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
• Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
• Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
• Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
• Avoid smoking and alcohol consumption.

• Avoid intercourse while on treatment with DU Knib 250mg Tablet.
• Regular, complete blood count monitoring is advised during the treatment.
• All patients should be tested for HER2 test before starting the treatment regimen.
• Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
• This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
• Regular ECG and electrolytes should be monitored while taking the medicine.

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin.