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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefra 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefra 10 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-10MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefra 10 Tablet

Lefra 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefra 10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefra 10 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefra 10 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefra 10 Tablet if you are pregnant or planning for pregnancy, as Lefra 10 Tablet may cause serious congenital disabilities. Lefra 10 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefra 10 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefra 10 Tablet as it could lead to increased dizziness and liver damage. Lefra 10 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefra 10 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefra 10 Tablet with or without food. Swallow Lefra 10 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefra 10 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefra 10 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefra 10 Tablet Works

Lefra 10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefra 10 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefra 10 Tablet

Do not take more than the prescribed dose of Lefra 10 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefra 10 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefra 10 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefra 10 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefra 10 Tablet may cause dizziness, so drive with caution. Lefra 10 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideNilotinib
Severe
LeflunomideIdarubicin
Severe

Drug-Drug Interactions

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LeflunomideNilotinib
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Lefra 10 Tablet with nilotinib can increase the risk of serious infections and liver problems.

How to manage the interaction:
Taking Lefra 10 Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination, fever, chills, joint pain or swelling, unusual bleeding, fatigue, nausea, vomiting, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LeflunomideIdarubicin
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Idarubicin and Lefra 10 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Lefra 10 Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideTolvaptan
Severe
How does the drug interact with Lefra 10 Tablet:
Co-administration of Lefra 10 Tablet with tolvaptan can increase the risk of liver problems.

How to manage the interaction:
Although taking Lefra 10 Tablet and tolvaptan together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideAzathioprine
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Azathioprine with Lefra 10 Tablet can increase the risk of side effects which may lead to anemia, bleeding problems, or infections.

How to manage the interaction:
Taking Lefra 10 Tablet with Azathioprine together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideCarboplatin
Severe
How does the drug interact with Lefra 10 Tablet:
Co-administration of Lefra 10 Tablet with carboplatin can increase the risk of infections.

How to manage the interaction:
Co-administration of carboplatin with Lefra 10 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideEfavirenz
Severe
How does the drug interact with Lefra 10 Tablet:
When Efavirenz is taken with Lefra 10 Tablet it can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Efavirenz with Lefra 10 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideEtanercept
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Lefra 10 Tablet with etanercept may affect bone marrow functioning, resulting in a low quantity of different types of blood cells. This increases your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Etanercept with Lefra 10 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideBleomycin
Severe
How does the drug interact with Lefra 10 Tablet:
The use of Lefra 10 Tablet together with bleomycin may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Bleomycin and Lefra 10 Tablet, you can take these medicines together if prescribed by your doctor. If you notice any signs of infection like fever, chills, or a sore throat, or if you experience symptoms like diarrhea, muscle aches, or difficulty breathing, contact your doctor immediately. Additionally, if you notice any weight loss or pain or burning while urinating, let your doctor know." Do not stop using any medications without a doctor's advice.
LeflunomideOlaparib
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Lefra 10 Tablet with olaparib may increase the risk of infections.

How to manage the interaction:
Although there is an interaction between Lefra 10 Tablet and olaparib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideBaricitinib
Severe
How does the drug interact with Lefra 10 Tablet:
Coadministration of baricitinib and Lefra 10 Tablet can raise the risk of infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Lefra 10 Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefra 10 Tablet Substitute

Substitutes safety advice
  • Lefno-10 Tablet 10's

    by Others

    13.50per tablet
  • Leftab 10 Tablet 10's

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    9.36per tablet
  • Dmlef 10mg Tablet 10's

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    12.51per tablet
  • Rumalef 10 Tablet 30's

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    8.94per tablet
  • Lefumide-10 Tablet 10's

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    12.29per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefra 10 Tablet . Alcohol intake, along with Lefra 10 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefra 10 Tablet while you are pregnant. Lefra 10 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefra 10 Tablet while you are breastfeeding. Lefra 10 Tablet passes into breast milk.

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Driving

Caution

Lefra 10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefra 10 Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefra 10 Tablet .

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Children

Unsafe

Lefra 10 Tablet is not approved for children under the age of 18 years.

FAQs

Lefra 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Lefra 10 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefra 10 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefra 10 Tablet . Take Lefra 10 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - LEF0001

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