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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefmaa 10Mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefmaa 10Mg Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Whats That

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Composition :

LEFLUNOMIDE-10MG

Manufacturer/Marketer :

Ankaa Pharmaceutical

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefmaa 10Mg Tablet

Lefmaa 10Mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefmaa 10Mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefmaa 10Mg Tablet at the same time every day as prescribed by your doctor. In some cases, Lefmaa 10Mg Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefmaa 10Mg Tablet if you are pregnant or planning for pregnancy, as Lefmaa 10Mg Tablet may cause serious congenital disabilities. Lefmaa 10Mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefmaa 10Mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefmaa 10Mg Tablet as it could lead to increased dizziness and liver damage. Lefmaa 10Mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefmaa 10Mg Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefmaa 10Mg Tablet with or without food. Swallow Lefmaa 10Mg Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefmaa 10Mg Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefmaa 10Mg Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefmaa 10Mg Tablet Works

Lefmaa 10Mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefmaa 10Mg Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefmaa 10Mg Tablet

Do not take more than the prescribed dose of Lefmaa 10Mg Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefmaa 10Mg Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefmaa 10Mg Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefmaa 10Mg Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefmaa 10Mg Tablet may cause dizziness, so drive with caution. Lefmaa 10Mg Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideAsparaginase
Severe
LeflunomideLevofloxacin
Severe

Drug-Drug Interactions

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LeflunomideAsparaginase
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Taking asparaginase with Lefmaa 10 mg Tablet may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between asparaginase and Lefmaa 10 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideLevofloxacin
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Coadministration of Levofloxacin and Lefmaa 10 mg Tablet can increase the risk of liver issues.

How to manage the interaction:
Although concomitant administration of levofloxacin alongside Lefmaa 10 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideIdarubicin
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Taking Idarubicin and Lefmaa 10 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Lefmaa 10 mg Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideGemcitabine
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Combining Gemcitabine with Lefmaa 10 mg Tablet can increase the risk or severity of developing serious infection

How to manage the interaction:
There may be a possibility of interaction between Lefmaa 10 mg Tablet and Gemcitabine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like feeling sick, having a fever or chills, diarrhea, a sore throat, muscle pain, trouble breathing, weight loss, pain or burning urination, joint pain, swelling or bruising, a rash or itching, loss of appetite, feeling tired, or having nausea, vomiting, dark urine, or bleeding. Do not discontinue any medications without consulting a doctor.
LeflunomideMethylprednisolone
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Using Lefmaa 10 mg Tablet together with methylprednisolone may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Lefmaa 10 mg Tablet and methylprednisolone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMinocycline
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Co-administration of Lefmaa 10 mg Tablet with minocycline can increase the risk or severity of liver disorder.

How to manage the interaction:
Although taking Lefmaa 10 mg Tablet and minocycline together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideCarbamazepine
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Taking carbamazepine and Lefmaa 10 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking carbamazepine and Lefmaa 10 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, yellowing of the skin or eyes, consult your doctor. Do not stop using any medication without consulting your doctor.
LeflunomideEltrombopag
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Coadministration of Lefmaa 10 mg Tablet and Eltrombopag can increase the risk or severity of liver damage.

How to manage the interaction:
Although there is a possible interaction between Lefmaa 10 mg Tablet and Eltrombopag, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, call a doctor right away. Do not stop using any medications without talking to a doctor.
LeflunomideErlotinib
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
When erlotinib is taken with Lefmaa 10 mg Tablet, it increases the risk of causing liver problems.

How to manage the interaction:
Although there is a possible interaction between Erlotinib and Lefmaa 10 mg Tablet, you can take these medicines together if advised by your doctor. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage, or bleeding, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
LeflunomideIbrutinib
Severe
How does the drug interact with Lefmaa 10 mg Tablet:
Co-administration of Ibrutinib and Lefmaa 10 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrutinib can be taken with Lefmaa 10 mg Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefmaa 10Mg Tablet Substitute

Substitutes safety advice
  • Lefno-10 Tablet 10's

    by Others

    13.50per tablet
  • Lefra 10 Tablet 10's

    by Others

    13.50per tablet
  • Leftab 10 Tablet 10's

    by Others

    9.36per tablet
  • Dmlef 10mg Tablet 10's

    by AYUR

    12.51per tablet
  • Rumalef 10 Tablet 30's

    by Others

    8.94per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefmaa 10Mg Tablet . Alcohol intake, along with Lefmaa 10Mg Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefmaa 10Mg Tablet while you are pregnant. Lefmaa 10Mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefmaa 10Mg Tablet while you are breastfeeding. Lefmaa 10Mg Tablet passes into breast milk.

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Driving

Caution

Lefmaa 10Mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefmaa 10Mg Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefmaa 10Mg Tablet .

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Children

Unsafe

Lefmaa 10Mg Tablet is not approved for children under the age of 18 years.

FAQs

Lefmaa 10Mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Lefmaa 10Mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefmaa 10Mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefmaa 10Mg Tablet . Take Lefmaa 10Mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

6/16 a, d/s jangpura extension, bhogal, delhi-110014, india
Other Info - LEF0055

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