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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefno-10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefno-10 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-10MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lefno-10 Tablet

Lefno-10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefno-10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefno-10 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefno-10 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefno-10 Tablet if you are pregnant or planning for pregnancy, as Lefno-10 Tablet may cause serious congenital disabilities. Lefno-10 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefno-10 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefno-10 Tablet as it could lead to increased dizziness and liver damage. Lefno-10 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefno-10 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefno-10 Tablet with or without food. Swallow Lefno-10 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefno-10 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefno-10 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefno-10 Tablet Works

Lefno-10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefno-10 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

What if I have taken an overdose of Lefno-10 Tablet

Do not take more than the prescribed dose of Lefno-10 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefno-10 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefno-10 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefno-10 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefno-10 Tablet may cause dizziness, so drive with caution. Lefno-10 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideDivalproex
Severe
LeflunomidePrasterone
Severe

Drug-Drug Interactions

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LeflunomideDivalproex
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Co-administration of divalproex and Lefno-10 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between divalproex and Lefno-10 Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomidePrasterone
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Taking Lefno-10 Tablet 10's with prasterone may increase the risk of liver problems.

How to manage the interaction:
Taking Prasterone with Lefno-10 Tablet 10's together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideSulfasalazine
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Taking sulfasalazine with Lefno-10 Tablet 10's can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between sulfasalazine and Lefno-10 Tablet 10's, it can be taken if prescribed by a doctor. Contact a doctor immediately if you develop paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
LeflunomideAcitretin
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Coadministration of Acitretin with Lefno-10 Tablet 10's may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Acitretin and Lefno-10 Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideSodium Valproate
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Co-administration of Lefno-10 Tablet 10's and sodium valproate can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Lefno-10 Tablet 10's and sodium valproate can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTizanidine
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Coadministration of tizanidine and Lefno-10 Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Lefno-10 Tablet 10's together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideRifampicin
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Taking Lefno-10 Tablet 10's with rifampicin can increase the risk of liver problems.

How to manage the interaction:
Although taking Rifampicin together with Lefno-10 Tablet 10's can result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience joint pain or swelling, unusual bleeding, fatigue, abdominal pain, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideCertolizumab
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Combining Certolizumab pegol with Lefno-10 Tablet 10's can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Lefno-10 Tablet 10's with Certolizumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, contact your doctor right away. These symptoms include feeling tired, dizzy, or lightheaded, having pale skin, experiencing frequent bleeding or bruising, having a fever or chills, having diarrhea or a sore throat, feeling muscle aches, having trouble breathing, losing weight unexpectedly, or feeling pain or burning when you urinate. Do not discontinue any medications without consulting your doctor.
LeflunomideAtomoxetine
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Taking atomoxetine with Lefno-10 Tablet 10's can cause liver problems.

How to manage the interaction:
Although there is an interaction between atomoxetine and Lefno-10 Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideCaspofungin
Severe
How does the drug interact with Lefno-10 Tablet 10's:
Lefno-10 Tablet 10's can cause liver problems, and combining it with other drugs, such as binimetinib, can raise the risk.

How to manage the interaction:
There may be a possibility of interaction between Lefno-10 Tablet 10's and Caspofungin, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact your doctor right away. These symptoms include liver problems, fever, rash, itching, loss of appetite, dark urine, stomach pain, unusual bleeding or bruising, feeling tired, and yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefno-10 Tablet Substitute

Substitutes safety advice
  • Lefra 10 Tablet 10's

    13.50per tablet
  • Leftab 10 Tablet 10's

    9.36per tablet
  • Rumalef 10 Tablet 30's

    8.94per tablet
  • Dmlef 10mg Tablet 10's

    by AYUR

    12.51per tablet
  • Lefumide-10 Tablet 10's

    12.29per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefno-10 Tablet . Alcohol intake, along with Lefno-10 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefno-10 Tablet while you are pregnant. Lefno-10 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefno-10 Tablet while you are breastfeeding. Lefno-10 Tablet passes into breast milk.

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Driving

Caution

Lefno-10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefno-10 Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefno-10 Tablet .

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Children

Unsafe

Lefno-10 Tablet is not approved for children under the age of 18 years.

FAQs

Lefno-10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
Lefno-10 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).
Lefno-10 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefno-10 Tablet . Take Lefno-10 Tablet for as long as your doctor has prescribed to treat your condition effectually.
Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - LEF0004

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