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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 9:31 AM IST

Istamet G-IR 50/1000/2 Tablet is an antidiabetic medicine used to treat type II diabetes. It contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine. Sitagliptin (dipeptidyl peptidase-4 inhibitor) works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin, which helps to remove sugar from the blood.

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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Apr-26

About Istamet G-IR 50/1000/2 Tablet

Istamet G-IR 50/1000/2 Tablet is an antidiabetic medicine used to treat type II diabetes. Type II Diabetes Mellitus is a serious condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels.

Istamet G-IR 50/1000/2 Tablet contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine; Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.

Istamet G-IR 50/1000/2 Tablet may cause certain side effects, such as vomiting, nausea, abdominal pain, headache, frequent urination, and allergic reactions. If these side effects persist or worsen, please consult your doctor. Istamet G-IR 50/1000/2 Tablet should be taken as prescribed by your doctor.

Istamet G-IR 50/1000/2 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Inform your doctor about the medical and complete medication history you are taking, including herbs and supplements, before starting the treatment with Istamet G-IR 50/1000/2 Tablet . Let your doctor know if you are pregnant or breastfeeding before taking Istamet G-IR 50/1000/2 Tablet .

Uses of Istamet G-IR 50/1000/2 Tablet

Treatment of Type II Diabetes Mellitus

Medicinal Benefits

Istamet G-IR 50/1000/2 Tablet  is a combination of three drugs: Sitagliptin, Metformin and Glimepiride. Istamet G-IR 50/1000/2 Tablet belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. It removes excess sugar from the body via urine, increases the amounts of certain natural substances that lower blood sugar when it is high, reduces sugar production by cells in the liver and delays sugar absorption from the intestines. 

Side Effects of Istamet G-IR 50/1000/2 Tablet

  • Headache
  • Nausea
  • Stomach upset
  • Vomiting
  • Abdominal pain
  • Frequent urination

Directions for Use

Istamet G-IR 50/1000/2 Tablet should be taken as advised by your doctor. It is advised not to take more than the recommended dose. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Istamet G-IR 50/1000/2 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements. This can help prevent unwanted effects. Istamet G-IR 50/1000/2 Tablet is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Istamet G-IR 50/1000/2 Tablet can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age. Avoid drinking alcohol while on Istamet G-IR 50/1000/2 Tablet  as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).

Therapeutic Class

ANTIDIABETICS

Drug-Drug Interactions

verifiedApollotooltip
SitagliptinGatifloxacin
Critical
MetforminIopamidol
Critical

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Habit Forming

No

How Istamet G-IR 50/1000/2 Tablet Works

Istamet G-IR 50/1000/2 Tablet contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine; Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.

What if I have taken an overdose of Istamet G-IR 50/1000/2 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Istamet G-IR 50/1000/2 Tablet may include severe gastrointestinal problems, low blood sugar reactions, nausea, vomiting, lethargy, and abdominal pain. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.
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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Istamet G-IR 50/1000/2 Tablet .

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Pregnancy

Caution

There are no adequate studies on the effect of Istamet G-IR 50/1000/2 Tablet in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Istamet G-IR 50/1000/2 Tablet .

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Breast Feeding

Caution

Istamet G-IR 50/1000/2 Tablet is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Istamet G-IR 50/1000/2 Tablet .

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Driving

Safe

Istamet G-IR 50/1000/2 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Istamet G-IR 50/1000/2 Tablet may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Istamet G-IR 50/1000/2 Tablet should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Istamet G-IR 50/1000/2 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

Plot No 107/108,Namli Block , Ranipool, East Sikkim 737135
Other Info - IST0063

Author Details

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FAQs

Istamet G-IR 50/1000/2 Tablet is an antidiabetic medicine used to treat type II diabetes.
Istamet G-IR 50/1000/2 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines. Glimepiride works by stimulating beta cells in the pancreas that produce insulin.
If you forget to take Istamet G-IR 50/1000/2 Tablet , take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double dose to make up the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.

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