Sitagliptin+metformin+glimepiride
About Sitagliptin+metformin+glimepiride
Glimepiride+metformin+sitagliptin is an antidiabetic medicine used to treat type II diabetes. Type II Diabetes Mellitus is a serious condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels.
Glimepiride+metformin+sitagliptin contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine; Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
Glimepiride+metformin+sitagliptin may cause certain side effects, such as vomiting, nausea, abdominal pain, headache, frequent urination, and allergic reactions. If these side effects persist or worsen, please consult your doctor. Glimepiride+metformin+sitagliptin should be taken as prescribed by your doctor.
Glimepiride+metformin+sitagliptin should be avoided if you are allergic to any of the medicines or the components in it. Inform your doctor about the medical and complete medication history you are taking, including herbs and supplements, before starting the treatment with Glimepiride+metformin+sitagliptin. Let your doctor know if you are pregnant or breastfeeding before taking Glimepiride+metformin+sitagliptin.
Uses of Sitagliptin+metformin+glimepiride
Medicinal Benefits
Glimepiride+metformin+sitagliptin is a combination of three drugs: Sitagliptin, Metformin and Glimepiride. Glimepiride+metformin+sitagliptin belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. It removes excess sugar from the body via urine, increases the amounts of certain natural substances that lower blood sugar when it is high, reduces sugar production by cells in the liver and delays sugar absorption from the intestines.
Directions for Use
Storage
Side Effects of Sitagliptin+metformin+glimepiride
- Headache
- Nausea
- Stomach upset
- Vomiting
- Abdominal pain
- Frequent urination
Drug Warnings
Glimepiride+metformin+sitagliptin should be avoided if you are allergic to any of the medicines or the components in it. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements. This can help prevent unwanted effects. Glimepiride+metformin+sitagliptin is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Glimepiride+metformin+sitagliptin can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age. Avoid drinking alcohol while on Glimepiride+metformin+sitagliptin as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
Drug Interactions
Drug-Drug Interactions: Glimepiride+metformin+sitagliptin interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-epileptic drugs (topiramate, lamotrigine)
Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Glimepiride+metformin+sitagliptin.
Drug-Disease Interactions: Inform your doctor if you have any kidney or liver disease or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Glimepiride+metformin+sitagliptin.
Pregnancy
cautionThere are no adequate studies on the effect of Glimepiride+metformin+sitagliptin in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Glimepiride+metformin+sitagliptin.
Breast Feeding
cautionGlimepiride+metformin+sitagliptin is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Glimepiride+metformin+sitagliptin.
Driving
safeGlimepiride+metformin+sitagliptin usually does not affect your ability to drive or operate machinery.
Liver
cautionGlimepiride+metformin+sitagliptin may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionRenal impairment also increases the risk of lactic acidosis. Hence, Glimepiride+metformin+sitagliptin should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeGlimepiride+metformin+sitagliptin is not recommended for children below 18 years as the safety and effectiveness were not established.
Habit Forming
Special Advise
- Glimepiride+metformin+sitagliptin may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Try to carry candies or sugar biscuits in your pocket every time you feel symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
- Lifestyle modifications are the most important step in controlling blood sugar levels.
- Your doctor may advise frequent blood tests to check your blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision.
FAQs
Glimepiride+metformin+sitagliptin is an antidiabetic medicine used to treat type II diabetes.
Glimepiride+metformin+sitagliptin is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines. Glimepiride works by stimulating beta cells in the pancreas that produce insulin.
If you forget to take Glimepiride+metformin+sitagliptin, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double dose to make up the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.
