apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Grafotas-25mg Softgel Capsule 5's

Grafotas-25mg Softgel Capsule 5's, Pack of 5
Thumbnail 0
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Grafotas-25mg Softgel Capsule is used to prevent organ transplant rejection. It is also used to treat inflammation and pain associated with psoriasis and rheumatoid arthritis. This medicine contains cyclosporine, which works by suppressing the immune system. It also helps reduce rapid skin cell growth, pain, and inflammation. It may sometimes cause common side effects such as headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

Read more

Available Offers

Coupon IconPHARMA18
18% OFF, applicable on orders > INR 2999
Coupon IconPHARMA10
10% OFF, applicable on orders > INR 799
Coupon IconPHARMA20
20% OFF, applicable on orders > INR 5499
rxMedicinePrescription drug

Whats That

tooltip

Extra Savings

Momverse
insurance
doctor consultation

Synonym :

CYCLOSPORIN

Composition :

CYCLOSPORINE-25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Grafotas-25mg Softgel Capsule

Grafotas-25mg Softgel Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis. Organ transplant rejection occurs when the immune system attacks a transplanted organ. Psoriasis is a long-lasting, inflammatory skin illness.  Rheumatoid arthritis is an autoimmune disease, where the body's immune system attacks its own tissue, leading to joint pain and damage.

Grafotas-25mg Softgel Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation), which are needed for T cells to activate and attack the body. Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.

You are advised to take Grafotas-25mg Softgel Capsule for as long as your doctor has prescribed it, depending on your medical condition. You may experience headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Grafotas-25mg Softgel Capsule for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Before taking Grafotas-25mg Softgel Capsule, inform your doctor if you have any allergies, kidney disease, uncontrolled high blood pressure, or any type of cancer. Grafotas-25mg Softgel Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and any medications you are taking to help rule out any potential unpleasant side effects.

Uses of Grafotas-25mg Softgel Capsule

Treatment of Organ Transplant Rejection: Grafotas-25mg Softgel Capsule is used in the prevention of organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It helps prevent organ rejection by suppressing the immune system.
Treatment of Psoriasis: Grafotas-25mg Softgel Capsule is used in the treatment of psoriasis. It helps reduce rapid skin cell growth and inflammation caused by psoriasis.
Treatment of Rheumatoid Arthritis: Grafotas-25mg Softgel Capsule is used in the treatment of rheumatoid arthritis. It helps reduce pain and inflammation in the joints and slows down joint damage.

Directions for Use

  • Grafotas-25mg Softgel Capsule ideally should be given 12 hours apart. It should be taken with water and swallowed whole.
  • Grapefruit and grapefruit juice should be avoided as they can raise ciclosporin levels in the blood. 

Medicinal Benefits

Grafotas-25mg Softgel Capsule is an immunosuppressant medication used to prevent organ transplant rejection. It contains cyclosporine, which suppresses the immune system and prevents your body from rejecting a new organ. It helps reduce rapid skin cell growth and inflammation caused by psoriasis. Additionally, it helps reduce pain and inflammation in the joints and slows down joint damage caused by an overactive immune system in people with rheumatoid arthritis.

How Grafotas-25mg Softgel Capsule Works

Grafotas-25mg Softgel Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation), which are needed for T cells to activate and attack the body. Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Grafotas-25mg Softgel Capsule

  • Headache
  • Vomiting
  • Nausea
  • High blood pressure
  • Increased growth of hair
  • Loss of appetite (feeling unwell and having an upset stomach)
  • Kidney disease
  • Diarrhoea

What if I have taken an overdose of Grafotas-25mg Softgel Capsule

Take Grafotas-25mg Softgel Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Symptoms of overdose may include headache, drowsiness, vomiting, increased heart rate, liver and kidney toxicity. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Grafotas-25mg Softgel Capsule if you are allergic to any immunosuppressant medicines or Cyclosporine. Let your doctor know if you have liver or kidney problems, high blood pressure, low magnesium levels, or high potassium levels. Your Grafotas-25mg Softgel Capsule may make you more susceptible to infections. Consult your doctor if you develop any signs of severe conditions, such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Grafotas-25mg Softgel Capsule inform your doctor if you have any type of cancer. Grafotas-25mg Softgel Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and any medications you are taking to help rule out any potential unpleasant side effects.

Drug-Drug Interactions

verifiedApollotooltip
CiclosporinBosentan
Critical
CiclosporinPitavastatin
Critical

Drug-Drug Interactions

Login/Sign Up

CiclosporinBosentan
Critical
How does the drug interact with Grafotas-25mg Softgel Capsule:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Grafotas-25mg Softgel Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Grafotas-25mg Softgel Capsule:
Coadministration of pitavastatin with Grafotas-25mg Softgel Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Grafotas-25mg Softgel Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinSimvastatin
Critical
How does the drug interact with Grafotas-25mg Softgel Capsule:
Combining Grafotas-25mg Softgel Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Grafotas-25mg Softgel Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinCidofovir
Critical
How does the drug interact with Grafotas-25mg Softgel Capsule:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Grafotas-25mg Softgel Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinBaricitinib
Critical
How does the drug interact with Grafotas-25mg Softgel Capsule:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Grafotas-25mg Softgel Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinMorphine
Severe
How does the drug interact with Grafotas-25mg Softgel Capsule:
Co-administration of morphine with Grafotas-25mg Softgel Capsule can increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking morphine with Grafotas-25mg Softgel Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without consulting a doctor.
CiclosporinIohexol
Severe
How does the drug interact with Grafotas-25mg Softgel Capsule:
Coadministration of iohexol with Grafotas-25mg Softgel Capsule may increases the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between iohexol and Grafotas-25mg Softgel Capsule, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
CiclosporinRitonavir
Severe
How does the drug interact with Grafotas-25mg Softgel Capsule:
Taking Grafotas-25mg Softgel Capsule with ritonavir may significantly increases the blood levels of Grafotas-25mg Softgel Capsule.

How to manage the interaction:
Taking ritonavir with Grafotas-25mg Softgel Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loose stools, abdominal pain, dizziness, weakness, headache, fits, shaking, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination, contact a doctor. Do not stop using any medications without talking to a doctor.
CiclosporinPosaconazole
Severe
How does the drug interact with Grafotas-25mg Softgel Capsule:
Coadministration of posaconazole and Grafotas-25mg Softgel Capsule together can enhance the effects of Grafotas-25mg Softgel Capsule.

How to manage the interaction:
Although using posaconazole and Grafotas-25mg Softgel Capsule together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, dizziness, weakness, vomiting, diarrhea, abdominal pain, or headache. Do not stop taking any medications without consulting a doctor.
CiclosporinAliskiren
Severe
How does the drug interact with Grafotas-25mg Softgel Capsule:
The combined use of aliskiren and Grafotas-25mg Softgel Capsule can significantly increase the blood levels and effects of aliskiren, which may lead to low blood pressure, hyperkalemia (high potassium levels) in the body. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythms. If you are elderly, dehydrated, or have kidney disease, diabetes, or severe heart failure, you are more prone to develop hyperkalemia while taking these medications.

How to manage the interaction:
Taking aliskiren and Grafotas-25mg Softgel Capsule will lead to an interaction, they can be taken together if your doctor has prescribed them. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities, such as 20-30 minutes of walking or swimming, would be helpful.
  • Practising yoga may also help improve joint flexibility and manage pain.
  • Maintain a healthy weight by engaging in regular low-impact exercises and eating a balanced diet.
  • Get adequate sleep, as rest can help reduce inflammation and swelling.
  • Follow heat or cold therapy by applying a cold or hot compress to the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
  • Foods containing flavonoids can help reduce inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Grafotas-25mg Softgel Capsule Substitute

Substitutes safety advice

  • Sandimmun Neoral 25mg Capsule 5's

    by Others

    ₹29.40per tablet

  • Panimun Bioral 25 mg Capsule 6's

    by Others

    ₹25.88per tablet

  • Psorid 25 Capsule 5's

    by Others

    ₹26.46per tablet

  • Arpimune ME 25 Capsule 5's

    by Others

    ₹22.32per tablet

  • Iminoral 25 mg Capsule 5's

    by Others

    ₹25.70per tablet

Product Substitutes

bannner image

Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Grafotas-25mg Softgel Capsule. It could lead to increased dizziness and drowsiness.

bannner image

Pregnancy

Caution

It is not known whether Grafotas-25mg Softgel Capsule will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

bannner image

Breast Feeding

Unsafe

It is not recommended to take Grafotas-25mg Softgel Capsule while you are breastfeeding. Grafotas-25mg Softgel Capsule passes into breast milk.

bannner image

Driving

Caution

Drive or operate machinery only if you are alert.

bannner image

Liver

Caution

Take Grafotas-25mg Softgel Capsule only if prescribed by the doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Grafotas-25mg Softgel Capsule.

bannner image

Children

Unsafe

Grafotas-25mg Softgel Capsule should not be given to children, as the efficacy and safety have not been established.

FAQs

Grafotas-25mg Softgel Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis.

Grafotas-25mg Softgel Capsule acts as an immunosuppressant, which helps reduce pain and inflammation in the joints and prevent joint stiffness, thereby relieving rheumatoid arthritis.

If you miss a dose of Grafotas-25mg Softgel Capsule, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose. Do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Grafotas-25mg Softgel Capsule. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Yes, using Grafotas-25mg Softgel Capsule may cause abnormal hair growth, although it does not affect everybody. Consult your doctor if you have any concerns.

Grafotas-25mg Softgel Capsule is known to decrease the immune system. As a result, it increases your risk of developing certain types of cancer, especially skin cancer. You should reduce your contact with sunlight and UV light by wearing suitable protective clothing. Sunscreen should be used regularly.

No, Grafotas-25mg Softgel Capsule is not a steroid. It is an immunosuppressant.

Yes, cyclosporine can cause weight gain. However, this is not a common side effect, and the amount of weight gain varies from person to person.

Yes, fatigue is a common side effect of cyclosporine. Many people who take cyclosporine report feeling tired or fatigued.

Grafotas-25mg Softgel Capsule is an immunosuppressant medication, meaning it weakens your immune system. This can make you more susceptible to infections and other health problems. Your doctor will likely order regular blood tests to monitor your health and ensure the medication is working effectively.

Grafotas-25mg Softgel Capsule has not been definitively linked to causing cancer. However, discussing any concerns you may have with your doctor is essential. They can provide personalized information about your health situation and why you take cyclosporine.

Common side effects of Grafotas-25mg Softgel Capsule may include headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Grafotas-25mg Softgel Capsule ideally should be given 12 hours apart. The capsules should be taken with water and swallowed whole. Grapefruit and grapefruit juice should be avoided, as they can increase ciclosporin levels in the blood.

The duration of Grafotas-25mg Softgel Capsule treatment varies depending on the underlying condition and individual response.

Always consult with your doctor or pharmacist before starting any new medications or supplements while taking Grafotas-25mg Softgel Capsule. They can help you identify potential interactions and recommend safe alternatives if necessary.

Yes, you can travel while taking cyclosporine. However, it's essential to plan and take necessary precautions. Ensure you have a sufficient supply of your medication, and be aware of any potential customs regulations or travel restrictions.

Generally, moderate exercise is safe while taking Grafotas-25mg Softgel Capsule. However, listening to your body and avoiding overexertion is essential, especially if you have any underlying health conditions.

Excessive alcohol consumption can increase the risk of side effects and interact with cyclosporine. It's best to limit alcohol intake or avoid it altogether while taking this medication.

Your doctor will determine the frequency of your blood tests based on your situation. However, regular monitoring is essential to ensure that cyclosporine works effectively and detects potential side effects.

If you miss a dose of Grafotas-25mg Softgel Capsule, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Some people may experience mood changes or anxiety while taking Grafotas-25mg Softgel Capsule. If you notice any changes in your mental health, it's important to talk to your doctor.

Grafotas-25mg Softgel Capsule occasionally causes blurred vision or eye irritation. If you experience any vision problems, contact your doctor.

Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.

Taking more than the recommended dosage does not provide additional benefit and can increase the risk of adverse effects.

Grafotas-25mg Softgel Capsule contains cyclosporine, an immunosuppressant.

Grafotas-25mg Softgel Capsule should not be given to children, as the efficacy and safety have not been established.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - GRA0345

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Doctor imageDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 22, 2025 | 1:53 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050715s035,050716s038lbl.pdf
  2. https://www.mayoclinic.org/drugs-supplements/cyclosporine-oral-route/description/drg-20075815
  3. https://medlineplus.gov/druginfo/meds/a601207.html
  4. https://www.drugs.com/disease-interactions/cyclosporine.html
  5. https://www.medicines.org.uk/emc/files/pil.5300.pdf
  6. https://www.webmd.com/drugs/2/drug-5645-9108/cyclosporine-oral/cyclosporine-oral/details
whatsapp Floating Button