Epimac Plus 50mg/325mg Tablet belongs to the class of medications called antispasmodics combined with a painkiller used to treat muscle spasms. Muscle spasm is the sudden painful and involuntary muscle contractions, which occur when the nerve impulses that control the muscle movements are damaged or interrupted. It is characterized by muscle tightness, joint stiffness, unusual posture, difficulty moving, and pain in affected muscles and joints.

Epimac Plus 50mg/325mg Tablet is a combination of two drugs: Eperisone (muscle relaxant) and Paracetamol (pain killer). Eperisone works by relaxing skeletal muscles and reducing myotonia (inability of muscles to relax). It can relax vascular smooth muscles (smooth muscle found in the wall of blood vessels) and improve blood circulation. It can also suppress pain reflexes. These effects of Epimac Plus 50mg/325mg Tablet help to reduce pain and spasms in the muscle effectively. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzyme's effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Collectively, Epimac Plus 50mg/325mg Tablet helps to reduce pain and spasms in the muscle effectively.

You should take this medicine exactly as prescribed by your doctor. The common side effects of Epimac Plus 50mg/325mg Tablet are nausea, vomiting, stomach discomfort, headache, weakness, drowsiness, and dizziness. Most of these side effects are mild and temporary. However, inform your doctor immediately if any of these side effects persist or get worse.

Before starting Epimac Plus 50mg/325mg Tablet, please inform your doctor if you have any known allergy Epimac Plus 50mg/325mg Tablet, heart, kidney, and liver problems. Consult your doctor before taking Epimac Plus 50mg/325mg Tablet if you are pregnant or planning for pregnancy. Do not take Epimac Plus 50mg/325mg Tablet if you are breastfeeding. Epimac Plus 50mg/325mg Tablet is not recommended for use in children. Elderly patients may require dose adjustments. Epimac Plus 50mg/325mg Tablet may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Epimac Plus 50mg/325mg Tablet as it could lead to increased dizziness and risk of liver damage.

Epimac Plus 50mg/325mg Tablet is a combination of two drugs, namely; Eperisone (muscle relaxant) and Paracetamol (painkiller). Eperisone is a muscle relaxant with an analgesic effect. It reduces muscle stiffness and spasticity, enabling the movement of muscles easily. It can be used during rehabilitation (restoring functional ability in people with physical disabilities) as it can allow voluntary movement of the upper and lower extremities without using muscle power. On the other hand, Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzyme's effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Epimac Plus 50mg/325mg Tablet helps in relieving pain due to muscle spasms.

• Nausea
• Vomiting
• Stomach discomfort
• Headache
• Weakness
• Drowsiness
• Dizziness

Do not take Epimac Plus 50mg/325mg Tablet if you have any known allergies to eperisone and paracetamol. Epimac Plus 50mg/325mg Tablet may cause liver damage, so it should be used cautiously in patients with liver diseases. Please consult your doctor to know if you are pregnant and planning to conceive. Do not take Epimac Plus 50mg/325mg Tablet if you are breastfeeding. Use Epimac Plus 50mg/325mg Tablet with caution in elderly patients; elder adults above 60 years may have increased drowsiness, confusion, and a higher risk of falling while taking Epimac Plus 50mg/325mg Tablet. Epimac Plus 50mg/325mg Tablet is not recommended in children as safety and effectiveness have not been established. People who are dehydrated for a long time should avoid the intake of Epimac Plus 50mg/325mg Tablet. If you notice dizziness, sleepiness, and weakness, you should refrain from activities that require you to stay alert such as driving or operating heavy machinery. Also, inform your doctor if these effects are persistent or worse, the doctor may make dose adjustments based on the severity of side-effects. Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Epimac Plus 50mg/325mg Tablet.

Drug-Drug Interactions: Epimac Plus 50mg/325mg Tablet may interact with a muscle relaxant (methocarbamol),  blood thinners (warfarin), lipid-lowering drugs (cholestyramine), analgesics (ibuprofen, aspirin), muscle relaxants (tizanidine), and anti-nausea agents (metoclopramide or domperidone).

Drug-Food Interactions: Avoid foods containing alcohol, caffeine such as coffee, tea, chocolate or cola.

Drug-Disease Interactions: Epimac Plus 50mg/325mg Tablet should be used with caution in patients with hepatic failure (liver diseases), chronic alcoholism, cardiac diseases (heart problems), hypertension, peptic ulcer, and renal dysfunction (kidney diseases) should use Epimac Plus 50mg/325mg Tablet with caution.

• METHOCARBAMOL
• WARFARIN
• CHOLESTYRAMINE
• IBUPROFEN
• ASPIRIN
• TIZANIDINE
• METOCLOPRAMIDE
• DOMPERIDONE

• Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Deep tissue massages with the help of a muscle massager are considered helpful.
• Avoid wearing tight-fitting clothes, instead, wear loose garments.
• Rest well and get optimal sleep (at least 8 hours for adults).
• Hot or cold therapy can help treat muscle spasms.
• Apply an ice pack or hot-pack on the muscle for 15-20 minutes.
• Try to include glycine (protein) in your daily diet, which is good food for your muscle.

Your doctor may advise you to undergo regular blood tests to monitor liver function while using Epimac Plus 50mg/325mg Tablet.

Muscle spasm: The sudden involuntary contractions of the muscle can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty moving, pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Exercise helps in muscle stretching so that they are less likely to spasm, tear and sprain.