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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Emtofa-5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Emtofa-5 Tablet

Emtofa-5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Emtofa-5 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Emtofa-5 Tablet if you are pregnant or breastfeeding. Emtofa-5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Emtofa-5 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Emtofa-5 Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Emtofa-5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Emtofa-5 Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Emtofa-5 Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Emtofa-5 Tablet Works

Emtofa-5 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Emtofa-5 Tablet

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

What if I have taken an overdose of Emtofa-5 Tablet

Take Emtofa-5 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Emtofa-5 Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Emtofa-5 Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Emtofa-5 Tablet . Emtofa-5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibAntithymocyte Globulin
Severe
TofacitinibLinezolid
Severe

Drug-Drug Interactions

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TofacitinibAntithymocyte Globulin
Severe
How does the drug interact with Emtofa-5 Tablet:
Using Emtofa-5 Tablet together with antithymocyte globulin can increase the risk of serious infections.

How to manage the interaction:
Taking Antithymocyte Globulin with Emtofa-5 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination contact your doctor. Do not discontinue any medications without consulting your doctor.
TofacitinibLinezolid
Severe
How does the drug interact with Emtofa-5 Tablet:
When used with linezolid, Emtofa-5 Tablet may raise the risk of serious infections.

How to manage the interaction:
Although taking linezolid and Emtofa-5 Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
TofacitinibThalidomide
Severe
How does the drug interact with Emtofa-5 Tablet:
Taking Thalidomide with Emtofa-5 Tablet may increase the risk of infection.

How to manage the interaction:
Although taking thalidomide and Emtofa-5 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TofacitinibBetamethasone
Severe
How does the drug interact with Emtofa-5 Tablet:
Using Emtofa-5 Tablet with betamethasone may increase the risk of serious infections. It may also increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Although there is an interaction between betamethasone and Emtofa-5 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibBudesonide
Severe
How does the drug interact with Emtofa-5 Tablet:
Using Emtofa-5 Tablet together with budesonide may increase the risk of serious infections.

How to manage the interaction:
Co-administration of budesonide along with Emtofa-5 Tablet can lead to an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibDasatinib
Severe
How does the drug interact with Emtofa-5 Tablet:
Using Emtofa-5 Tablet together with dasatinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Emtofa-5 Tablet with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibPhenytoin
Severe
How does the drug interact with Emtofa-5 Tablet:
Using Emtofa-5 Tablet together with phenytoin may reduce the blood levels and effects of Emtofa-5 Tablet.

How to manage the interaction:
Taking Emtofa-5 Tablet with Phenytoin together can result in an interaction, but it can be taken if your doctor has advised it. Doctors can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.
TofacitinibPrednisolone
Severe
How does the drug interact with Emtofa-5 Tablet:
Co-administration of Emtofa-5 Tablet and Prednisolone can increase the risk of serious infections, diverticular disease (development of small bulges in the lining of the intestine), or gastrointestinal bleeding or perforation.

How to manage the interaction:
Although taking Emtofa-5 Tablet and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the coughing fluid, weight loss, red or inflamed skin, body sores, pain or burning when urinating, severe abdominal pain, fever, nausea, or vomiting, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibMethotrexate
Severe
How does the drug interact with Emtofa-5 Tablet:
Coadministration of methotrexate with Emtofa-5 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Emtofa-5 Tablet and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting to a doctor.
TofacitinibEtanercept
Severe
How does the drug interact with Emtofa-5 Tablet:
Taking Etanercept with Emtofa-5 Tablet can increase the risk of serious infections as well as sometimes may lead to cancers.

How to manage the interaction:
Although there is a possible interaction between Emtofa-5 Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Emtofa-5 Tablet Substitute

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  • Tofe-5 Tablet 10's

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Alcohol

Caution

It is not known if alcohol interacts with Emtofa-5 Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Emtofa-5 Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Emtofa-5 Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Emtofa-5 Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Emtofa-5 Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Emtofa-5 Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Emtofa-5 Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

Emtofa-5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Emtofa-5 Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Emtofa-5 Tablet . Consult your doctor before taking Emtofa-5 Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Emtofa-5 Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Emtofa-5 Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Emtofa-5 Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Emtofa-5 Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Emtofa-5 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Emtofa-5 Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Emtofa-5 Tablet may begin working within 2-8 weeks after starting the treatment.

Emtofa-5 Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Emtofa-5 Tablet , inform the doctor if you are taking tocilizumab.

Prior to starting Emtofa-5 Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

A - 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - EMT0040

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