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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

T-Jaki 5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About T-Jaki 5 Tablet

T-Jaki 5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
T-Jaki 5 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking T-Jaki 5 Tablet if you are pregnant or breastfeeding. T-Jaki 5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of T-Jaki 5 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow T-Jaki 5 Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

T-Jaki 5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. T-Jaki 5 Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. T-Jaki 5 Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How T-Jaki 5 Tablet Works

T-Jaki 5 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of T-Jaki 5 Tablet

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

What if I have taken an overdose of T-Jaki 5 Tablet

Take T-Jaki 5 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take T-Jaki 5 Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking T-Jaki 5 Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking T-Jaki 5 Tablet . T-Jaki 5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibCladribine
Severe
TofacitinibCeritinib
Severe

Drug-Drug Interactions

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TofacitinibCladribine
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking T-Jaki 5 Tablet 10's with Cladribine may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and T-Jaki 5 Tablet 10's together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TofacitinibCeritinib
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking Ceritinib with T-Jaki 5 Tablet 10's may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Ceritinib and T-Jaki 5 Tablet 10's, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like feeling tired, dizzy, or faint, or if you have a fever, diarrhea, or difficulty breathing, it is important to contact a doctor. Do not discontinue any medications without consulting a doctor.
TofacitinibDactinomycin
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking T-Jaki 5 Tablet 10's with Dactinomycin may increase the risk of serious infection.

How to manage the interaction:
Taking Dactinomycin with T-Jaki 5 Tablet 10's together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning when you pee, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
TofacitinibClozapine
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
When T-Jaki 5 Tablet 10's and Clozapine are taken together, that may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between T-Jaki 5 Tablet 10's and Clozapine, but it can be taken if prescribed by a doctor. Your doctor can recommend other options that won't cause problems when taken together. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibVoclosporin
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking T-Jaki 5 Tablet 10's with Voclosporin may increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between T-Jaki 5 Tablet 10's and Voclosporin, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibPemetrexed
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking T-Jaki 5 Tablet 10's with Pemetrexed may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Pemetrexed and T-Jaki 5 Tablet 10's, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibPrednisolone
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Co-administration of T-Jaki 5 Tablet 10's and Prednisolone can increase the risk of serious infections, diverticular disease (development of small bulges in the lining of the intestine), or gastrointestinal bleeding or perforation.

How to manage the interaction:
Although taking T-Jaki 5 Tablet 10's and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the coughing fluid, weight loss, red or inflamed skin, body sores, pain or burning when urinating, severe abdominal pain, fever, nausea, or vomiting, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibDoxorubicin
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking T-Jaki 5 Tablet 10's with Doxorubicin may increase the risk of serious infection.

How to manage the interaction:
Although taking T-Jaki 5 Tablet 10's and Doxorubicin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to keep a close eye on your condition. Do not stop using any medications without a doctor's advice.
TofacitinibIbrutinib
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking Ibrutinib with T-Jaki 5 Tablet 10's may increase the risk of infection.

How to manage the interaction:
Although taking T-Jaki 5 Tablet 10's and Ibrutinib together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TofacitinibItraconazole
Severe
How does the drug interact with T-Jaki 5 Tablet 10's:
Taking Itraconazole with T-Jaki 5 Tablet 10's may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between T-Jaki 5 Tablet 10's and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

T-Jaki 5 Tablet Substitute

Substitutes safety advice
  • TFCT NIB Tablet 10's

    by AYUR

    43.52per tablet
  • Tofajak Tablet 60's

    19.80per tablet
  • Tofadoz Tablet 10's

    by AYUR

    44.24per tablet
  • Betrecep 5 mg Tablet 14's

    28.61per tablet
  • Tofe-5 Tablet 10's

    by AYUR

    17.10per tablet
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Alcohol

Caution

It is not known if alcohol interacts with T-Jaki 5 Tablet , so please consult a doctor.

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Pregnancy

Unsafe

T-Jaki 5 Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with T-Jaki 5 Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking T-Jaki 5 Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

T-Jaki 5 Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. T-Jaki 5 Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

T-Jaki 5 Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

T-Jaki 5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
T-Jaki 5 Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of T-Jaki 5 Tablet . Consult your doctor before taking T-Jaki 5 Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of T-Jaki 5 Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
T-Jaki 5 Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting T-Jaki 5 Tablet if you are trying to become pregnant or if you have any concerns regarding this.
T-Jaki 5 Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
T-Jaki 5 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
T-Jaki 5 Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
T-Jaki 5 Tablet may begin working within 2-8 weeks after starting the treatment.
T-Jaki 5 Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting T-Jaki 5 Tablet , inform the doctor if you are taking tocilizumab.
Prior to starting T-Jaki 5 Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

463, 4 Th Floor, Rpg House, Dr. Annie Besant Road, Worli, Mumbai €“ 400 030. Maharashtra, India
Other Info - TJA0001

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