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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dytor E 20 Combikit is used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to oedema (fluid retention). It works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain) in the future. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid.

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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Dytor E 20 Combikit

Dytor E 20 Combikit belongs to a class of medicine called 'diuretics' (water pills) primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to oedema (fluid retention). Oedema or fluid overload is associated with pulmonary hypertension (high blood pressure in the lung) or heart failure (irregular heart pumping). Leg swelling is the main characteristic of oedema, accompanied by shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia) and swelling in other hands or abdomen areas.

Dytor E 20 Combikit is a combination of medications containing Eplerenone and Torsemide, which are prescribed for the treatment of resistant oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Dytor E 20 Combikit works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain) in the future.

Take Dytor E 20 Combikit as prescribed by your doctor. Depending upon your medical condition, you are advised to take Dytor E 20 Combikit for as long as your doctor has prescribed it for you. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. Most of these side effects of Dytor E 20 Combikit do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Dytor E 20 Combikit of your own, as doing so may raise your blood pressure, thereby increasing the risk of heart disease and stroke. Inform your doctor if you are suffering from kidney, liver or heart disease. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Dytor E 20 Combikit can be prescribed accordingly. Please tell your doctor if you are taking any other medicines or are allergic to the Dytor E 20 Combikit. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Dytor E 20 Combikit

Treatment of Oedema (fluid overload)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Dytor E 20 Combikit is primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to oedema (fluid retention). Dytor E 20 Combikit is a combination of medications containing Eplerenone and Torsemide. Both Eplerenone and Torsemide are diuretics and are prescribed for the treatment of resistant oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Dytor E 20 Combikit works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain) in the future.

How Dytor E 20 Combikit Works

Dytor E 20 Combikit is a combination of medications containing Eplerenone and Torsemide, which are prescribed for the treatment of resistant oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Dytor E 20 Combikit works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain) in the future.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dytor E 20 Combikit

  • Dehydration
  • Electrolyte disturbances (calcium, magnesium, and sodium)
  • Constipation
  • Itching
  • Increased uric acid

What if I have taken an overdose of Dytor E 20 Combikit

Do not take more than the prescribed dose of Dytor E 20 Combikit as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Dytor E 20 Combikit should not be given to the people allergic to Dytor E 20 Combikit, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, pregnant women, or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Dytor E 20 Combikit can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you are taking Dytor E 20 Combikit and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using Dytor E 20 Combikit. Do not take any extra potassium supplements or potassium-rich foods such as bananas and broccoli with Dytor E 20 Combikit. It may lead to an excessive increase in blood potassium levels (hyperkalemia). Please take Dytor E 20 Combikit at least 4 hours before sleeping to avoid frequent urination at night.

Drug-Drug Interactions

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EplerenoneSaquinavir
Critical
EplerenoneSpironolactone
Critical

Drug-Drug Interactions

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EplerenoneSaquinavir
Critical
How does the drug interact with Dytor E 20 Combikit:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Dytor E 20 Combikit. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Dytor E 20 Combikit together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenoneSpironolactone
Critical
How does the drug interact with Dytor E 20 Combikit:
Combining Dytor E 20 Combikit with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Dytor E 20 Combikit, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePotassium chloride
Critical
How does the drug interact with Dytor E 20 Combikit:
Using Dytor E 20 Combikit together with Potassium chloride may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking potassium chloride with Dytor E 20 Combikit is not recommended. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult the doctor immediately. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePotassium citrate
Critical
How does the drug interact with Dytor E 20 Combikit:
Taking Dytor E 20 Combikit with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Dytor E 20 Combikit, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Dytor E 20 Combikit:
Coadministration of posaconazole with Dytor E 20 Combikit can increase the blood levels of Dytor E 20 Combikit. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Dytor E 20 Combikit, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EplerenoneKetoconazole
Critical
How does the drug interact with Dytor E 20 Combikit:
Coadministration of Ketoconazole with Dytor E 20 Combikit can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Dytor E 20 Combikit is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Dytor E 20 Combikit:
Combining Dytor E 20 Combikit with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Dytor E 20 Combikit, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Dytor E 20 Combikit:
The blood levels and effects of Dytor E 20 Combikit may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Dytor E 20 Combikit and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
EplerenoneClarithromycin
Critical
How does the drug interact with Dytor E 20 Combikit:
Co-administration of Dytor E 20 Combikit and Clarithromycin may significantly increase the blood levels and effects of Dytor E 20 Combikit.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Dytor E 20 Combikit is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Dytor E 20 Combikit:
Co-administration of Dytor E 20 Combikit and Ritonavir may significantly increase the blood levels of Dytor E 20 Combikit.

How to manage the interaction:
Taking Ritonavir and Dytor E 20 Combikit together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise like walking improves your blood flow.
  • When possible, elevate your legs or the swollen area on a chair or pillows.
  • Avoid standing or sitting for extended periods of time.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Dytor E 20 Combikit Substitute

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Alcohol

Caution

You are recommended not to consume alcohol along with Dytor E 20 Combikit to avoid unpleasant side effects.

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Pregnancy

Caution

Dytor E 20 Combikit should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Dytor E 20 Combikit.

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Breast Feeding

Caution

Dytor E 20 Combikit should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Dytor E 20 Combikit.

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Driving

Caution

It is not recommended to drive after taking Dytor E 20 Combikit as it may occasionally cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position).

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Liver

Caution

Dytor E 20 Combikit to be taken with caution, especially if you have a history of Liver diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Kidney

Caution

Dytor E 20 Combikit to be taken with caution, especially if you have a history of Kidney diseases. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Unsafe

Dytor E 20 Combikit is not recommended for children below 12 years of age.

FAQs

Dytor E 20 Combikit is used to treat oedema (fluid overload).
Dytor E 20 Combikit works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain) in the future.
The main side effect of Dytor E 20 Combikit is peeing (urination) more often than normal. Most people need to pee about 30 minutes after taking Dytor E 20 Combikit and again within a few hours. Do not take Dytor E 20 Combikit before going to bed, or you may have to wake up at night to go for urination frequently.
Yes, the Dytor E 20 Combikit is known to cause dehydration (excessive loss of fluids). The patient may experience dry mouth, decreased urine output, excessive thirst, and hypotension (decreased blood pressure). So, please increase the intake of fluids to avoid extreme dehydration.
Yes, Dytor E 20 Combikit can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Dytor E 20 Combikit. Please monitor your electrolyte level regularly to avoid increased blood potassium levels.
Yes, Dytor E 20 Combikit may occasionally cause dizziness due to orthostatic hypotension (sudden drop in blood pressure when standing from a lying position) or passing out. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Dytor E 20 Combikit should be swallowed as a whole with water; do not crush or chew it.
Dytor E 20 Combikit should be taken with caution and only if prescribed by the doctor if you have kidney or liver disease. Please consult the doctor if you have any concerns.
Dytor E 20 Combikit may cause side effects like dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. If the side effects are persistent, reach out to your doctor.
Treatment with Dytor E 20 Combikit requires regular monitoring of serum potassium, sodium and creatinine levels. Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor. Regular monitoring of uric acid in patients with gouty arthritis.
Other medications can be taken with Dytor E 20 Combikit only if advised by the doctor. Please consult the doctor before taking other medicines with Dytor E 20 Combikit to prevent any interactions.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DYT0019

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