Douse MR 50mg/325mg/2mg Tablet is a combination medicine that contains pain relievers and muscle relaxants. It is used to treat spasticity (muscle stiffness and spasms) associated with pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. A muscle spasm occurs due to involuntary contractions of a muscle. A spasm may be a muscle cramp or feel tight or stiff, like a knot.

Douse MR 50mg/325mg/2mg Tablet contains Diclofenac, Paracetamol and Tizanidine. Diclofenac and Paracetamol blocks prostaglandins (PGs) that cause pain and swelling. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. As a result, Douse MR 50mg/325mg/2mg Tablet helps to reduce muscle stiffness, spasms, and pain. In addition, paracetamol lowers the high temperature by affecting the chemical messengers in an area of the brain that regulates body temperature.

Douse MR 50mg/325mg/2mg Tablet is prescribed medication, and it should be taken as directed by the doctor. In some cases, you may experience common side effects such as vomiting, diarrhoea, headaches, drowsiness and ringing in your ears (tinnitus), fluctuations in blood pressure, dry mouth, stomach upsets, and a decrease or increase in heart rate. Most of these side effects do not require medical attention and will resolve gradually. If any of these effects persist, consult your doctor.

Avoid taking Douse MR 50mg/325mg/2mg Tablet if you are allergic to any of its components. Before taking Douse MR 50mg/325mg/2mg Tablet, tell your doctor about your medical history and other medications you are currently taking to rule out any possible side effects. Douse MR 50mg/325mg/2mg Tablet is not recommended for use in pregnancy. If you are breastfeeding, consult your doctor before taking Douse MR 50mg/325mg/2mg Tablet. This medicine may cause dizziness, so drive only if you are alert and focused. Douse MR 50mg/325mg/2mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol while on treatment with Douse MR 50mg/325mg/2mg Tablet as it could lead to liver damage.

Douse MR 50mg/325mg/2mg Tablet contains Diclofenac, Paracetamol and Tizanidine. Diclofenac and Paracetamol inhibit the production of prostaglandins (PGs), which induce pain and swelling. Tizanidine modulates the spinal cord and brain centres. This aids in the relief of muscle stiffness and the improvement of muscle movements. As a result, Douse MR 50mg/325mg/2mg Tablet aids in relieving muscle stiffness, spasms, and pain. Besides this, paracetamol reduces elevated temperature by altering the chemical messengers in the brain area that regulates body temperature.

• Vomiting
• Diarrhoea
• Headaches
• Drowsiness
• Ringing in your ears (tinnitus)
• Fluctuations in blood pressure
• Dry mouth
• Stomach upsets
• Decrease or increase in heart rate

Do not take Douse MR 50mg/325mg/2mg Tablet if you are allergic to its components. Inform your doctor about all your medical conditions, especially if you have/ had hepatotoxicity, hypotension, renal dysfunction or renal toxicities, asthma, fluid retention, GI toxicity, rash, or thrombosis (blood clots). It is not recommended to take Douse MR 50mg/325mg/2mg Tablet during pregnancy or whilst breastfeeding. Douse MR 50mg/325mg/2mg Tablet may cause drowsiness and dizziness, so drive only when you are alert. Douse MR 50mg/325mg/2mg Tablet is not recommended for children as safety and effectiveness have not been established. Do not stop taking Douse MR 50mg/325mg/2mg Tablet unless your doctor tells you to. Treatment with Douse MR 50mg/325mg/2mg Tablet should be stopped gradually. Stopping treatment suddenly may cause effects such as an increase in heart rate and high blood pressure.

Drug-Drug Interactions: Douse MR 50mg/325mg/2mg Tablet may interact with certain pain killers (e.g. hydrocodone), anti-depressants (e.g. fluvoxamine, escitalopram), antibiotics (e.g. ciprofloxacin), antihypertensives (e.g. metoprolol), anticoagulant (e.g. apixaban), certain painkillers (e.g. celecoxib), and antiretroviral medicine (e.g. tenofovir).

Drug-Food Interactions: Do not drink alcohol while taking Douse MR 50mg/325mg/2mg Tablet.

Drug-Disease Interactions: Douse MR 50mg/325mg/2mg Tablet may interact with various disease conditions that include ulcer or perforation, bleeding problems, hepatotoxicity (liver impairment), hypotension, renal dysfunction or toxicities, asthma, fluid retention, GI toxicity, rash, thrombosis (blood clots).

• HYDROCODONE
• FLUVOXAMINE
• ESCITALOPRAM
• CIPROFLOXACIN
• METOPROLOL
• APIXABAN
• CELECOXIB
• TENOFOVIR

• Regular exercise helps muscle stretch, making them less likely to spasm, tear, and sprain. Mild activities such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Rest well, and get plenty of sleep.
• Change your position at least every two hours to avoid developing pressure sores.
• Hot or cold therapy can help treat muscle spasms.
• Apply an ice pack or hot pack on the muscle for 15-20minutes.
• Stay hydrated, drink plenty of water.

Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. A spasm may be a twitch in the muscle or feel tight or hard, like a knot.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific body area). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.