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Written By , M Pharmacy
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 2:47 PM IST
Diltra 50mg/300mg/300mg Tablet is used to treat HIV-1 infection. It works by increasing the immune cells that help fight infections in the body and interfering with the working of certain enzymes which are necessary for the reproduction of the virus; thereby decreasing the amount of HIV in the blood. In some cases, this medicine may cause side effects such as fatigue, diarrhoea, headache, pain, fever, cough, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions. Practise safe sex and other necessary precautions as this medicine does not prevent the spread of HIV infection.
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About Diltra 50mg/300mg/300mg Tablet

Diltra 50mg/300mg/300mg Tablet belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses.
 
Diltra 50mg/300mg/300mg Tablet contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.
 
You are advised to take Diltra 50mg/300mg/300mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as fatigue, diarrhoea, headache, pain, rash, depression, fever, cough, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Practise safe sex and other necessary precautions as Diltra 50mg/300mg/300mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Diltra 50mg/300mg/300mg Tablet may cause dizziness, so drive with caution. Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35 kg. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Diltra 50mg/300mg/300mg Tablet

Treatment of HIV infection

Medicinal Benefits

Diltra 50mg/300mg/300mg Tablet is a combination of three drugs, namely: Dolutegravir, Lamivudine and Tenofovir disoproxil fumarate. Diltra 50mg/300mg/300mg Tablet belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. Dolutegravir is an integrase inhibitor that increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine is a nucleoside reverse transcriptase inhibitor, and Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. They work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.

Side Effects of Diltra 50mg/300mg/300mg Tablet

  • Fatigue
  • Diarrhoea
  • Headache
  • Pain
  • Rash
  • Depression
  • Fever
  • Cough
  • Insomnia 

Directions for Use

Swallow Diltra 50mg/300mg/300mg Tablet as a whole with water; do not chew or crush it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Diltra 50mg/300mg/300mg Tablet if you are allergic to any of its components. Inform your doctor if you have a history of hepatitis B or C infection, bone problems, pancreas disorder, kidney/liver problems, or if you are taking dofetilide (anti-arrhythmic agent). Practise safe sex and other necessary precautions as Diltra 50mg/300mg/300mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Diltra 50mg/300mg/300mg Tablet may cause dizziness, so drive with caution. Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35 kg. Talk to your doctor immediately if you notice any signs or symptoms of infection or inflammation.

Therapeutic Class

ANTIRETROVIRAL AGENTS

Drug-Drug Interactions

verifiedApollotooltip
DolutegravirDofetilide
Critical
LamivudineEmtricitabine
Critical

Drug-Food Interactions

verifiedApollotooltip
DOLUTEGRAVIR-50MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MGHerbal products/medicines
Moderate

Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost the immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or by doing whatever makes you happy.

Habit Forming

No

How Diltra 50mg/300mg/300mg Tablet Works

Diltra 50mg/300mg/300mg Tablet contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.

What if I have taken an overdose of Diltra 50mg/300mg/300mg Tablet

Take Diltra 50mg/300mg/300mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.
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Alcohol

Caution

It is not known whether Diltra 50mg/300mg/300mg Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Diltra 50mg/300mg/300mg Tablet might cause embryo-fetal toxicity when taken at the time of conception and during early pregnancy. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Consult your doctor if you have any concerns regarding this.

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Driving

Caution

Diltra 50mg/300mg/300mg Tablet may cause dizziness. So, drive or operating machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35kgs. Consult your doctor if you have any concerns.

Manufacturer/Marketer address

Aurobindo Pharma Limited, Plot No. 2, Maitrivihar, Ameerpet, Hyderabad - 500038 , Telangana, India.
Other Info - DILT232

Author Details

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FAQs

Diltra 50mg/300mg/300mg Tablet is used to treat HIV infection.
Diltra 50mg/300mg/300mg Tablet contains Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.
Do not stop taking Diltra 50mg/300mg/300mg Tablet without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Diltra 50mg/300mg/300mg Tablet for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Diltra 50mg/300mg/300mg Tablet.
Diltra 50mg/300mg/300mg Tablet might cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect. Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, and deep rapid breathing, as these could be the signs of lactic acidosis.
Diltra 50mg/300mg/300mg Tablet may cause bone problems such as bone pain, softening or thinning of bone which might lead to bone fractures. A regular bone density test is advised while taking Diltra 50mg/300mg/300mg Tablet.
Antacids, laxatives, or other medicines containing magnesium, aluminium or buffered medicines (medicines used to neutralise stomach acids) should be taken 2 hours before and 6 hours after taking Diltra 50mg/300mg/300mg Tablet. Consult your doctor if you have any concerns.
You can take iron or calcium supplements with Diltra 50mg/300mg/300mg Tablet if you have taken Diltra 50mg/300mg/300mg Tablet with food. If you haven’t taken Diltra 50mg/300mg/300mg Tablet with food, take Diltra 50mg/300mg/300mg Tablet 2 hours before or 6 hours after taking iron or calcium supplements. Consult your doctor if you have any concerns.

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