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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 22, 2024 | 7:36 PM IST
Depzil Plus Tablet is used to treat Alzheimer's disease (memory loss). It contains Donepezil and Memantine, which balance the levels of chemical messengers in the brain and help transmit nerve signals. It may cause side effects such as vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Psyco Remedies Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Depzil Plus Tablet

Depzil Plus Tablet is used to treat Alzheimer's disease (memory loss). Alzheimer's disease is a progressive neurodisorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells (neurons) to die. 

Depzil Plus Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Take Depzil Plus Tablet as prescribed by your doctor. You are advised to take Depzil Plus Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably, take it before just bedtime. In some cases, you may experience vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Depzil Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Depzil Plus Tablet may cause dizziness and sleepiness. So, do not drive a car or operate any machinery that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Depzil Plus Tablet as it may cause diarrhoea. Before using Depzil Plus Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.

Uses of Depzil Plus Tablet

Treatment of Alzheimer's disease (memory loss).

Medicinal Benefits

Depzil Plus Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals. Donepezil is a cholinesterase inhibitor that works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.

Directions for Use

Swallow Depzil Plus Tablet as a whole with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Depzil Plus Tablet

  • Vomiting
  • Loss of appetite
  • Dryness in the mouth
  • Dizziness
  • Weight loss
  • Nausea
  • Diarrhoea
  • Headache

Drug Warnings

Do not take Depzil Plus Tablet if you are allergic to Depzil Plus Tablet or any of its ingredients. Depzil Plus Tablet may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Depzil Plus Tablet as it may cause diarrhoea. Before using Depzil Plus Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. Take Depzil Plus Tablet preferably just before bedtime.

Drug Interactions

Drug-Drug Interaction: Depzil Plus Tablet is known to interact with pain killers (aspirin), anticholinergics (donepezil), antiparkinson's disease (amantadine), ketamine, dextromethorphan), anti-fungal (ketoconazole),  anti-epilepsy medicines (phenytoin, carbamazepine, phenobarbital), corticosteroid (dexamethasone), anti-tuberculosis medicines (rifampin), stomach ulcer medicines (cimetidine, ranitidine), dopaminergic agonists (bromocriptine).

Drug-Food Interaction: $name is known to interact with alcohol as it might increase sleepiness.

Drug-Disease Interaction: Depzil Plus Tablet is known to interact in patients with kidney or liver disease, asthma, heart disease, history of seizures, stomach ulcers, history of intestinal bleeding, urination problems, bladder obstruction.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • DONEPEZIL
  • AMANTADINE
  • KETOCONAZOLE
  • PHENYTOIN
  • CARBAMAZEPINE
  • DEXAMETHASONE
  • PHENOBARBITAL
  • CIMETIDINE
  • RANITIDINE
  • BROMOCRIPTINE

Habit Forming

No

Diet & Lifestyle Advise

  • Find the humour in your daily life. Try to watch light-hearted shows to help relieve stress.

  • You can try increasing your mindfulness, by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.

  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve diarrhoea.

  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.

  • Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake. 

  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.

  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of memory loss.

Special Advise

  • Depzil Plus Tablet causes drowsiness. Avoid doing activities that require your complete focus and attention like driving when on this drug.

  • Avoid consuming alcohol while on this medication as it can lead to dangerous side effects.

  • The safety and efficacy are not established in pregnant or breastfeeding. Discuss with your doctor in such situations about changing/replacing the medicine with safer alternatives.

  • Do not self-medicate.

Disease/Condition Glossary

Alzheimer's disease: It is a progressive neurologic disorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells to die. One of the very common causes of Alzheimer's disease is dementia (memory loss), which affects the person's ability to function independently. Very early signs of the disease are forgetting recent events and conversations, and as the disease progresses, it can lead to severe memory impairment. 

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Alcohol

Caution

Taking alcohol, along with Depzil Plus Tablet , may increase its drowsiness effect and cause excessive sleepiness.

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Pregnancy

Caution

Depzil Plus Tablet is a pregnancy category C drug. It is not known whether it will harm the baby. So, take only if prescribed by a doctor.

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Breast Feeding

Caution

It is not known whether Depzil Plus Tablet passes through breast milk or not. So, caution should be exercised if you are breastfeeding.

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Driving

Unsafe

Depzil Plus Tablet is known to cause drowsiness, so please do not drive a car or operate any machinery which requires mental alertness.

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Liver

Caution

Depzil Plus Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Depzil Plus Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Caution

The safety and efficacy of Depzil Plus Tablet in children have not been established.

Country of origin

India

Manufacturer/Marketer address

3M India Ltd, Concorde Block, Ub City, #24, Vittal Mallya Road, Bangalore, Karnataka - 560001 India
Other Info - DEP0140

Author Details

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FAQs

Depzil Plus Tablet is used to treat Alzheimer's disease (memory loss), a progressive neurodisorder that affects the brain.
Depzil Plus Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.
No, it is recommended not to take Depzil Plus Tablet before s surgery as it contains Donepezil, which is a cholinesterase inhibitor and is likely to exaggerate muscle relaxation during anaesthesia. So, please inform your doctor before surgery if you are taking Depzil Plus Tablet as he might stop it &2 hours before undergoing surgery.
Yes, the use of Depzil Plus Tablet can cause diarrhoea. In some cases, the patient may experience diarrhoea. So, please increase the intake of fluids to avoid dehydration. And also do not take any other medicines without speaking to a doctor.
Yes, Depzil Plus Tablet is known to cause weight loss. So, while taking Depzil Plus Tablet , you should constantly monitor your body weight to avoid major weight loss.
Taking Depzil Plus Tablet in more than the recommended dose can cause unpleasant side-effects such as dizziness, tremor, agitation, convulsion, coma, nausea, vomiting, changes in heart rhythm, decreased blood pressure, and change in body fluid/salt balance.
Yes, Alzheimer's disease (memory loss) generally occurs in people who are elderly and aged. So, Depzil Plus Tablet is safe for the elderly population, but the dose should be given by a doctor depending upon any underlining disease condition you are suffering from. Also, never self medicate.
Depzil Plus Tablet may cause side effects like vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Depzil Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Alzheimer's disease is a progressive neurologic disorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells to die. One of the very common causes of Alzheimer's disease is dementia (memory loss), which affects the person's ability to function independently.
Take Depzil Plus Tablet preferably just before bedtime or as advised by the doctor.
Depzil Plus Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Depzil Plus Tablet can be taken along with my other regular medicines if advised by the doctor. Please consult the doctor before taking other medicines with Depzil Plus Tablet to prevent any interactions/side effects.
Do not discontinue Depzil Plus Tablet without consulting your doctor. To treat your condition effectively, keep taking Depzil Plus Tablet for the prescribed duration.
Store Depzil Plus Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Depzil Plus Tablet is contraindicated if you are allergic to any of its components.
Inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.
Taking more than the recommended dose of Depzil Plus Tablet may cause an overdose. The symptoms of overdose include slow heart rate, severe dizziness, drowsiness, vomiting, sweating, weakness, trouble walking, agitation, confusion, unusual thoughts or behaviour, hallucinations, fainting, fits, and shallow or weak breathing. If you suspect the patient has taken an overdose or notice signs of overdose, please consult a doctor immediately.

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