Donibiz-M5 Tablet is used to treat Alzheimer's disease (memory loss). Alzheimer's disease is a progressive neurodisorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells (neurons) to die. 

Donibiz-M5 Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Take Donibiz-M5 Tablet as prescribed by your doctor. You are advised to take Donibiz-M5 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably, take it before just bedtime. In some cases, you may experience vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Donibiz-M5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Donibiz-M5 Tablet may cause dizziness and sleepiness. So, do not drive a car or operate any machinery that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donibiz-M5 Tablet as it may cause diarrhoea. Before using Donibiz-M5 Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.

Donibiz-M5 Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals. Donepezil is a cholinesterase inhibitor that works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.

• Vomiting
• Loss of appetite
• Dryness in the mouth
• Dizziness
• Weight loss
• Nausea
• Diarrhoea
• Headache

Do not take Donibiz-M5 Tablet if you are allergic to Donibiz-M5 Tablet or any of its ingredients. Donibiz-M5 Tablet may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donibiz-M5 Tablet as it may cause diarrhoea. Before using Donibiz-M5 Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. Take Donibiz-M5 Tablet preferably just before bedtime.

Drug-Drug Interaction: Donibiz-M5 Tablet is known to interact with pain killers (aspirin), anticholinergics (donepezil), antiparkinson's disease (amantadine), ketamine, dextromethorphan), anti-fungal (ketoconazole),  anti-epilepsy medicines (phenytoin, carbamazepine, phenobarbital), corticosteroid (dexamethasone), anti-tuberculosis medicines (rifampin), stomach ulcer medicines (cimetidine, ranitidine), dopaminergic agonists (bromocriptine).

Drug-Food Interaction: $name is known to interact with alcohol as it might increase sleepiness.

Drug-Disease Interaction: Donibiz-M5 Tablet is known to interact in patients with kidney or liver disease, asthma, heart disease, history of seizures, stomach ulcers, history of intestinal bleeding, urination problems, bladder obstruction.

• ASPIRIN
• DONEPEZIL
• AMANTADINE
• KETOCONAZOLE
• PHENYTOIN
• CARBAMAZEPINE
• DEXAMETHASONE
• PHENOBARBITAL
• CIMETIDINE
• RANITIDINE
• BROMOCRIPTINE

• Find the humour in your daily life. Try to watch light-hearted shows to help relieve stress.

• You can try increasing your mindfulness, by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.

• Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve diarrhoea.

• Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.

• Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake. 

• You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.

• Try to spend time with your friends and family. Having a strong social network may help you lower your risk of memory loss.

• Donibiz-M5 Tablet causes drowsiness. Avoid doing activities that require your complete focus and attention like driving when on this drug.

• Avoid consuming alcohol while on this medication as it can lead to dangerous side effects.

• The safety and efficacy are not established in pregnant or breastfeeding. Discuss with your doctor in such situations about changing/replacing the medicine with safer alternatives.

• Do not self-medicate.

Alzheimer's disease: It is a progressive neurologic disorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells to die. One of the very common causes of Alzheimer's disease is dementia (memory loss), which affects the person's ability to function independently. Very early signs of the disease are forgetting recent events and conversations, and as the disease progresses, it can lead to severe memory impairment.