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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Donep-M Tablet is used to treat Alzheimer's disease (memory loss). It contains Donepezil and Memantine, which balance the levels of chemical messengers in the brain and help transmit nerve signals. It may cause side effects such as vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Donep-M Tablet

Donep-M Tablet is used to treat Alzheimer's disease (memory loss). Alzheimer's disease is a progressive neurodisorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells (neurons) to die. 

Donep-M Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Take Donep-M Tablet as prescribed by your doctor. You are advised to take Donep-M Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably, take it before just bedtime. In some cases, you may experience vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Donep-M Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Donep-M Tablet may cause dizziness and sleepiness. So, do not drive a car or operate any machinery that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donep-M Tablet as it may cause diarrhoea. Before using Donep-M Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.

Uses of Donep-M Tablet

Treatment of Alzheimer's disease (memory loss).

Directions for Use

Swallow Donep-M Tablet as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Donep-M Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals. Donepezil is a cholinesterase inhibitor that works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.

How Donep-M Tablet Works

Donep-M Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Donep-M Tablet

  • Vomiting
  • Loss of appetite
  • Dryness in the mouth
  • Dizziness
  • Weight loss
  • Nausea
  • Diarrhoea
  • Headache

What if I have taken an overdose of Donep-M Tablet

Do not take more than the prescribed dose of Donep-M Tablet as it may cause overdose. The symptoms of overdose include slow heart rate, severe dizziness, drowsiness, vomiting, sweating, weakness, trouble walking, agitation, confusion, unusual thoughts or behaviour, hallucinations, fainting, fits, shallow or weak breathing. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Donep-M Tablet if you are allergic to Donep-M Tablet or any of its ingredients. Donep-M Tablet may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donep-M Tablet as it may cause diarrhoea. Before using Donep-M Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. Take Donep-M Tablet preferably just before bedtime.

Drug-Drug Interactions

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DonepezilIomeprol
Severe
DonepezilIohexol
Severe

Drug-Drug Interactions

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DonepezilIomeprol
Severe
How does the drug interact with Donep-M Tablet 15's:
Co-administration of Iomeprol and Donep-M Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Co-administration of Donep-M Tablet 15's with Iomeprol can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor if you experience any symptoms like shortness of breath, irregular heart rhythms, or problems with movement and memory. Do not discontinue any medications without first consulting your doctor.
DonepezilIohexol
Severe
How does the drug interact with Donep-M Tablet 15's:
Coadministration of Iohexol and Donep-M Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Although taking Donep-M Tablet 15's and Iohexol together can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
DonepezilIopamidol
Severe
How does the drug interact with Donep-M Tablet 15's:
The combined use of iopamidol and Donep-M Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizures or head injury.

How to manage the interaction:
Taking Donep-M Tablet 15's with Iopamidol together can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor if you experience any symptoms like shortness of breath, irregular heart rhythms, or problems with movement and memory. Do not stop using any medications without a doctor's advice.
DonepezilTramadol
Severe
How does the drug interact with Donep-M Tablet 15's:
Coadministration of Donep-M Tablet 15's with tramadol can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Taking Donep-M Tablet 15's with tramadol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, increased heart rate, blurred vision, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DonepezilBupropion
Severe
How does the drug interact with Donep-M Tablet 15's:
Taking bupropion with Donep-M Tablet 15's may increase the levels of Donep-M Tablet 15's and the risk of developing seizures.

How to manage the interaction:
Co-administration of bupropion along with Donep-M Tablet 15's can lead to an interaction, but it can be taken when recommended by a doctor. However, if you experience sudden dizziness, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DonepezilCyclopentolate
Severe
How does the drug interact with Donep-M Tablet 15's:
Coadministration of Cyclopentolate with Donep-M Tablet 15's can reduce the levels and effects of Cyclopentolate.

How to manage the interaction:
There may be a possibility of interaction between Cyclopentolate and Donep-M Tablet 15's, but it can be taken when prescribed by a doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, or rapid heartbeat consult your doctor immediately. Do not stop using any medications without talking to your doctor.
DonepezilMetrizamide
Severe
How does the drug interact with Donep-M Tablet 15's:
The combined use of metrizamide and Donep-M Tablet 15's can increase the risk of developing seizures. If you have a history of seizures or a head injury, contact your doctor immediately.

How to manage the interaction:
Although there is a possible interaction between Donep-M Tablet 15's and Metrizamide, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Find the humour in your daily life. Try to watch light-hearted shows to help relieve stress.

  • You can try increasing your mindfulness, by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.

  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve diarrhoea.

  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.

  • Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake. 

  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.

  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of memory loss.

Habit Forming

No

Therapeutic Class

CENTRAL NERVOUS SYSTEM AGENTS

Donep-M Tablet Substitute

Substitutes safety advice
  • Donamem 5 Tablet 10's

    18.00per tablet
  • Alzil-M 5 Tablet 10's

    20.88per tablet
  • Cogmentin 5 mg Tablet 15's

    by AYUR

    17.34per tablet
  • Aricep-M Tablet 10's

    by AYUR

    13.99per tablet
  • Donamind M 5mg/5mg Tablet 10's

    by AYUR

    17.10per tablet
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Alcohol

Caution

Taking alcohol, along with Donep-M Tablet , may increase its drowsiness effect and cause excessive sleepiness.

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Pregnancy

Caution

Donep-M Tablet is a pregnancy category C drug. It is not known whether it will harm the baby. So, take only if prescribed by a doctor.

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Breast Feeding

Caution

It is not known whether Donep-M Tablet passes through breast milk or not. So, caution should be exercised if you are breastfeeding.

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Driving

Unsafe

Donep-M Tablet is known to cause drowsiness, so please do not drive a car or operate any machinery which requires mental alertness.

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Liver

Caution

Donep-M Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Donep-M Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Caution

The safety and efficacy of Donep-M Tablet in children have not been established.

FAQs

Donep-M Tablet is used to treat Alzheimer's disease (memory loss), a progressive neurodisorder that affects the brain.
Donep-M Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.
No, it is recommended not to take Donep-M Tablet before s surgery as it contains Donepezil, which is a cholinesterase inhibitor and is likely to exaggerate muscle relaxation during anaesthesia. So, please inform your doctor before surgery if you are taking Donep-M Tablet as he might stop it &2 hours before undergoing surgery.
Yes, the use of Donep-M Tablet can cause diarrhoea. In some cases, the patient may experience diarrhoea. So, please increase the intake of fluids to avoid dehydration. And also do not take any other medicines without speaking to a doctor.
Yes, Donep-M Tablet is known to cause weight loss. So, while taking Donep-M Tablet , you should constantly monitor your body weight to avoid major weight loss.
Taking Donep-M Tablet in more than the recommended dose can cause unpleasant side-effects such as dizziness, tremor, agitation, convulsion, coma, nausea, vomiting, changes in heart rhythm, decreased blood pressure, and change in body fluid/salt balance.
Yes, Alzheimer's disease (memory loss) generally occurs in people who are elderly and aged. So, Donep-M Tablet is safe for the elderly population, but the dose should be given by a doctor depending upon any underlining disease condition you are suffering from. Also, never self medicate.
Donep-M Tablet may cause side effects like vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Donep-M Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Alzheimer's disease is a progressive neurologic disorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells to die. One of the very common causes of Alzheimer's disease is dementia (memory loss), which affects the person's ability to function independently.
Take Donep-M Tablet preferably just before bedtime or as advised by the doctor.
Donep-M Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Donep-M Tablet can be taken along with my other regular medicines if advised by the doctor. Please consult the doctor before taking other medicines with Donep-M Tablet to prevent any interactions/side effects.
Do not discontinue Donep-M Tablet without consulting your doctor. To treat your condition effectively, keep taking Donep-M Tablet for the prescribed duration.
Store Donep-M Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Donep-M Tablet is contraindicated if you are allergic to any of its components.
Inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.
Taking more than the recommended dose of Donep-M Tablet may cause an overdose. The symptoms of overdose include slow heart rate, severe dizziness, drowsiness, vomiting, sweating, weakness, trouble walking, agitation, confusion, unusual thoughts or behaviour, hallucinations, fainting, fits, and shallow or weak breathing. If you suspect the patient has taken an overdose or notice signs of overdose, please consult a doctor immediately.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - DON0095

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