Costigmin Injection 5 ml belongs to a group of medicines called 'anticholinesterase agents/acetylcholinesterase inhibitors', primarily used to reverse the effects of muscle relaxant and anesthesia medicines used during surgery. Certain medicines like propofol, etomidate, ketamine which is an anesthetic medicine cause anesthesia (sedative action) during surgery. Several muscles relaxant medicines are also used during surgery like vecuronium, rocuronium relaxes the muscles during surgery.

Costigmin Injection 5 ml contains two medicines namely: Glycopyrrolate and Neostigmine. Neostigmine increases levels of a substance known as acetylcholine by stopping an enzyme required for the breakdown of acetylcholine involved in transmission between nerve impulses and muscle movements. It is used at the end of surgery to reverse the effects of several medicines used during surgery like anesthetics and muscle relaxants. Glycopyrrolate is an anticholinergic It works by blocking the activity of a chemical messenger (acetylcholine) in the brain. It is added to avoid the unwanted effects of Neostigmine like stomach acid, excess saliva production and decreased heart rate.

 You are advised to take Costigmin Injection 5 ml for as long as your doctor has prescribed it for you depending on your medical condition.  Some people may experience constipation, dry mouth, nausea, vomiting, visual disturbance, dizziness, diarrhea, too much saliva, dryness of skin, increased pressure of the eye, stomach cramps, the uncontrolled need of passing urine. Most of these side effects of Costigmin Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not use Costigmin Injection 5 ml if you are allergic to Costigmin Injection 5 ml or any of its contents. Costigmin Injection 5 ml should not be taken if you have difficulty in passing urine and blockage in the intestine. Costigmin Injection 5 ml should not be taken in the conditions like asthma, kidney disease and heart disease. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Costigmin Injection 5 ml. It is not recommended to drive after taking Costigmin Injection 5 ml as it may cause your eyesight to become week. Costigmin Injection 5 ml can be given to children if prescribed by the doctor, the dose depends on the child’s age and weight.

Costigmin Injection 5 ml contains two medicines namely: Glycopyrrolate and Neostigmine. It is primarily used to reverse the effects of muscle relaxant and anesthesia medicines at the end of surgery. Neostigmine increases levels of a substance known as acetylcholine by stopping an enzyme required for the breakdown of acetylcholine involved in transmission between nerve impulses and muscle movements. It is used at the end of surgery to reverse the effects of several medicines used during surgery like anesthetics and muscle relaxants. Glycopyrrolate is an anticholinergic It works by blocking the activity of a chemical messenger (acetylcholine) in the brain. It is added to avoid the unwanted effects of Neostigmine like stomach acid, excess saliva production and decreased heart rate.

• Constipation
• Dry mouth
• Nausea
• Vomiting
• Visual disturbance
• Dizziness
• Diarrhea
• Too much saliva
• Dryness of skin
• Increased pressure of the eye
• Stomach cramps
• Uncontrolled need of passing urine

Let your doctor know if you use any other medicines or supplements before using Costigmin Injection 5 ml. Do not use Costigmin Injection 5 ml if you are allergic to Costigmin Injection 5 ml or any of its contents. Costigmin Injection 5 ml should not be taken if you have difficulty in passing urine and blockage in the intestine. Costigmin Injection 5 ml should not be taken in the conditions like asthma, breathing difficulties, stomach ulcers, high blood pressure, high temperature (fever), kidney disease, and heart disease. Before taking Costigmin Injection 5 ml inform your doctor if you have muscle weakness (myasthenia gravis), fit disorder, parkinson’s disease, enlarged prostate gland, abdominal pain and vomiting. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Costigmin Injection 5 ml. It is not recommended to drive after taking Costigmin Injection 5 ml as it may cause your eyesight to become week. Costigmin Injection 5 ml can be given to children if prescribed by the doctor; the dose depends on the child’s age and weight.

Drug-Drug Interaction: Costigmin Injection 5 ml may interact with antidepressants (lithium, amitriptyline, imipramine), medicines used for mental illness (clozapine), pain killers (nefopam), antiviral (amantadine), muscle relaxants (suxamethonium), antibiotics (gentamicin, streptomycin, cholistimethate sodium), medicines for heart disease (procainamide, propafenone, quinidine), antimalarial (chloroquine), a medicine used in migraine (propranolol).

Drug-Food Interaction: Do not consume alcohol while taking Costigmin Injection 5 ml as it could lead to increased dizziness and weak eyesight.

Drug-Disease Interaction: Costigmin Injection 5 ml may have interactions with asthma, muscle weakness, stomach ulcers, high blood pressure, high temperature (fever), kidney disease, and heart disease

• LITHIUM
• AMITRIPTYLINE
• IMIPRAMINE
• CLOZAPINE
• AMANTADINE
• SUXAMETHONIUM
• GENTAMICIN
• STREPTOMYCIN
• PROCAINAMIDE
• PROPAFENONE
• QUINIDINE
• CHLOROQUINE
• PROPRANOLOL

• Maintain proper weight by following a healthy diet.
• Avoid smoking and alcohol consumption.
• Try to avoid stress by practising meditation or yoga.
• Include fruits and vegetables in your diet as they contain anti-oxidants.
• Limit foods with high cholesterol and saturated fats.
• Cut down on sugar, salt and processed foods.
• Drink plenty of water.

Do not use Costigmin Injection 5 ml on your own, it is given only by a doctor.

Anesthesia is the use of medicines to avoid pain during surgery. These medicines are known as anesthetics. They may be given by injection, inhalation, topical lotion, spray, eye drops or skin patch. They cause you to have a loss of awareness or feeling. Specific medicines like propofol, etomidate, ketamine which is an anesthetic medicine cause anesthesia (sedative action) during surgery. Several muscles relaxant medicines are also used during surgery like vecuronium, rocuronium relaxes the muscles during surgery.