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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Bizisa Injection is used to treat Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia. Bizisa Injection contains Bendamustine; it works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medication is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Whats That

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Synonym :

BENDAMUSTINE HYDROCHLORIDE

Composition :

BENDAMUSTINE-100MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Bizisa Injection

Bizisa Injection belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Bizisa Injection contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Bizisa Injection may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Bizisa Injection. Hence, do not self-administer.

Bizisa Injection should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Bizisa Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Bizisa Injection

Treatment of Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia

Directions for Use

A trained healthcare professional will administer Bizisa Injection. Hence, do not self-administer. 

Medicinal Benefits

Bizisa Injection contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

How Bizisa Injection Works

Bizisa Injection contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Bizisa Injection

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

What if I have taken an overdose of Bizisa Injection

As Bizisa Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Bizisa Injection may cause rapid, irregular, or pounding heartbeat.

Drug Warnings

Bizisa Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Bizisa Injection may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Bizisa Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Bizisa Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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BendamustineBaricitinib
Severe
BendamustineCladribine
Severe

Drug-Drug Interactions

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BendamustineBaricitinib
Severe
How does the drug interact with Bizisa Injection 1's:
Combining Bizisa Injection 1's with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Bizisa Injection 1's and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineCladribine
Severe
How does the drug interact with Bizisa Injection 1's:
Combining Cladribine with Bizisa Injection 1's can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Bizisa Injection 1's and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineInfliximab
Severe
How does the drug interact with Bizisa Injection 1's:
When Bizisa Injection 1's is taken with Infliximab, it can cause the metabolism of Bizisa Injection 1's to speed up. This can increase the risk of developing serious infections.

How to manage the interaction:
Taking Bizisa Injection 1's with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Do not stop using any medications without talking to a doctor.
BendamustineClozapine
Severe
How does the drug interact with Bizisa Injection 1's:
Combining Bizisa Injection 1's with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Bizisa Injection 1's and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately If you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
BendamustineTofacitinib
Severe
How does the drug interact with Bizisa Injection 1's:
Using tofacitinib together with Bizisa Injection 1's may increase the risk of developing serious infections.

How to manage the interaction:
Taking Tofacitinib with Bizisa Injection 1's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
BendamustineLeflunomide
Severe
How does the drug interact with Bizisa Injection 1's:
Combining Bizisa Injection 1's with Leflunomide can increase the likelihood of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Bizisa Injection 1's and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms - like an infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Bizisa Injection Substitute

Substitutes safety advice
  • ZUMUSTIN 100MG INJECTION

    6350.90per tablet
  • BENDIT 100MG INJECTION

    2987.30per tablet
  • BIMODE 100MG INJECTION 20ML

    106.03per tablet
  • PURPLZ 100MG VIAL INJECTION

    3660.10per tablet
  • Genmus 100 Injection 1's

    1993.07per tablet
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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Bizisa Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Bizisa Injection. Use reliable methods of birth control while on treatment with Bizisa Injection.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Bizisa Injection. You should not breastfeed while on treatment with Bizisa Injection.

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Driving

Not applicable

-

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Bizisa Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Bizisa Injection is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Bizisa Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Bizisa Injection is not recommended for use in children as the safety and efficacy is not established.

FAQs

Bizisa Injection is used to treat Non-Hodgkin’s disease and Chronic Lymphocytic Leukaemia.
Bizisa Injection contains Bendamustine, which inhibits the DNA and RNA transcription essential for cancer cell growth.
Bizisa Injection may cause reactivation of serious infections, myelosuppression, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Bizisa Injection is safe when used as per the dose and duration advised by a doctor.
Bizisa Injection has the vesicant (irritant) properties.
Yes, the use of Bizisa Injection can cause hair loss and constipation as a side effect. This will gradually reduce over time and does not require any medical attention. However, please contact a doctor if this condition persists for longer or worsens.
Bizisa Injection can cross the blood-brain barrier and can be utilized for treating cancers that have spread to the brain.
Bizisa Injection may cause side effects such as diarrhoea, back pain, vomiting, stomach pain, cough, pain at the site of injection, fever, constipation, decreased blood pressure, rashes, and decreased weight. Please, contact a doctor if these side effects persist for longer durations.

Country of origin

INDIA

Manufacturer/Marketer address

D' Block, 3Rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - BIZ0025

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